Clusters of Characterized Proteins

Clustering the characterized proteins for lctO (L-lactate oxidase or 2-monooxygenase) in L-threonine catabolism

Or see other characterized proteins similar to lctO

Or see all steps for L-threonine catabolism

Or cluster curated proteins matching a keyword

Definition of lctO

• Curated proteins or TIGRFams with EC 1.13.12.4
• Curated proteins or TIGRFams with EC 1.1.3.2
• Ignore hits to items matching 1.1.3.15 when looking for 'other' hits
• Comment: L-lactate oxidase (EC 1.13.12.4, formerly 1.1.3.2) oxidizes L-lactate to acetate and CO2 under aerobic conditions. Some of these enzymes produce pyruvate (and hydroxgen peroxide) instead, but are still given this EC number. Either way, the acetate can be used for growth. However this enzyme is mostly found in fermentative bacteria, so its role could be to detoxify the accumulated lactate. Since L-lactate is a (S)-2-hydroxy-acid, ignore any similarities to (S)-2-hydroxy-acid oxidases (1.1.3.15)

Fetched 7 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 7 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by cluster

Aerococcus viridans

D4YFM2 lactate oxidase monomer (EC 1.1.3.2) from Aerococcus viridans ATCC 11563
D4YFM2 L-lactate oxidase (EC 1.1.3.2) from Aerococcus viridans
PFams: FMN_dh
374 amino acids: PaperBLAST, CDD (Cluster 1)

Q44467 L-lactate oxidase (EC 1.1.3.2) from Aerococcus viridans
PFams: FMN_dh
374 amino acids: PaperBLAST, CDD (Cluster 1)

Chlamydomonas reinhardtii

F8WQN2 L-lactate oxidase (EC 1.1.3.2) from Chlamydomonas reinhardtii
PFams: FMN_dh, IMPDH
384 amino acids: PaperBLAST, CDD (Cluster 1)

Nostoc PCC

Q8Z0C8 L-lactate oxidase (EC 1.1.3.2) from Nostoc sp. PCC 7120
PFams: FMN_dh
365 amino acids: PaperBLAST, CDD (Cluster 1)

Schizosaccharomyces pombe

YKN3_SCHPO / Q9HDX2 Uncharacterized lactate 2-monooxygenase PB1A11.03; EC 1.13.12.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: FMN_dh
407 amino acids: PaperBLAST, CDD (Cluster 1)

Streptococcus iniae

A9QH69 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15); L-lactate oxidase (EC 1.1.3.2) from Streptococcus iniae
PFams: FMN_dh
390 amino acids: PaperBLAST, CDD (Cluster 1)

LA2M_STRIN / O33655 Lactate 2-monooxygenase; Lactate oxidase; EC 1.13.12.4 from Streptococcus iniae (Streptococcus shiloi)
O33655 L-lactate oxidase (EC 1.1.3.2) from Streptococcus iniae
PFams: FMN_dh
403 amino acids: PaperBLAST, CDD (Cluster 1)