Other Characterized Proteins Similar to tdcE

Finding the characterized proteins for tdcE (2-ketobutyrate formate-lyase) in L-threonine catabolism

Or see clustering for step tdcE

Or see all steps for L-threonine catabolism

Or cluster curated proteins matching a keyword

Definition of tdcE

• Curated sequence P42632: pyruvate formate-lyase 4/2-ketobutyrate formate-lyase. PFL-like enzyme TdcE; Keto-acid formate acetyltransferase; Keto-acid formate-lyase; Ketobutyrate formate-lyase; KFL; Pyruvate formate-lyase; PFL; EC 2.3.1.-; EC 2.3.1.54
• Curated sequence P09373: formate C-acetyltransferase (EC 2.3.1.54). pyruvate formate-lyase
• Ignore hits to items matching 2.3.1.54 when looking for 'other' hits
• Comment: This reaction is not linked to an EC number. E. coli tdcB (PF42632) and pflB (P09373) seem to be the only ones that are characterized. Many pyruvate-formate lyases (EC 2.3.1.54) can probably carry out this reaction, so they are ignored.

Fetched 2 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 6 other characterized sequences. (Found 8 hits including self hits.)

Removing ignored items reduces this to 0 close sequences.

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for tdcE.)

PFLB_STAAC / Q5HJF4 Formate acetyltransferase; Pyruvate formate-lyase; EC 2.3.1.54 from Staphylococcus aureus (strain COL)
PFams: PFL-like, Gly_radical
749 amino acids: PaperBLAST, CDD, SwissProt::Q5HJF4
66% identical to

b0903 pyruvate formate-lyase from Escherichia coli K-12 substr. MG1655
P09373 formate C-acetyltransferase (EC 2.3.1.54) from Escherichia coli
PFams: PFL-like, Gly_radical
760 amino acids: PaperBLAST, CDD

Q46266 pyruvate formate-lyase subunit (EC 2.3.1.54) from Clostridium pasteurianum
Q46266 formate C-acetyltransferase (EC 2.3.1.54) from Clostridium pasteurianum
PFams: PFL-like, Gly_radical
740 amino acids: PaperBLAST, CDD, BRENDA::Q46266
61% identical to

b0903 pyruvate formate-lyase from Escherichia coli K-12 substr. MG1655
P09373 formate C-acetyltransferase (EC 2.3.1.54) from Escherichia coli
PFams: PFL-like, Gly_radical
760 amino acids: PaperBLAST, CDD

Q1RS83 pyruvate formate lyase (EC 2.3.1.54) from Chlamydomonas reinhardtii
Q1RS83 formate C-acetyltransferase (EC 2.3.1.54) from Chlamydomonas reinhardtii
PFams: PFL-like, Gly_radical
852 amino acids: PaperBLAST, CDD, metacyc::MONOMER-17779
57% identical to

b0903 pyruvate formate-lyase from Escherichia coli K-12 substr. MG1655
P09373 formate C-acetyltransferase (EC 2.3.1.54) from Escherichia coli
PFams: PFL-like, Gly_radical
760 amino acids: PaperBLAST, CDD

Q59934 pyruvate formate-lyase subunit (EC 2.3.1.54) from Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
PFams: PFL-like, Gly_radical
775 amino acids: PaperBLAST, CDD, metacyc::MONOMER-13094
44% identical to

b0903 pyruvate formate-lyase from Escherichia coli K-12 substr. MG1655
P09373 formate C-acetyltransferase (EC 2.3.1.54) from Escherichia coli
PFams: PFL-like, Gly_radical
760 amino acids: PaperBLAST, CDD

A0A0H2ZQE4 formate C-acetyltransferase (EC 2.3.1.54) from Streptococcus pneumoniae
PFams: PFL-like, Gly_radical
774 amino acids: PaperBLAST, CDD, BRENDA::A0A0H2ZQE4
43% identical to

b0903 pyruvate formate-lyase from Escherichia coli K-12 substr. MG1655
P09373 formate C-acetyltransferase (EC 2.3.1.54) from Escherichia coli
PFams: PFL-like, Gly_radical
760 amino acids: PaperBLAST, CDD

O66391 formate C-acetyltransferase (EC 2.3.1.54) from Streptococcus equinus
PFams: PFL-like, Gly_radical
774 amino acids: PaperBLAST, CDD, BRENDA::O66391
43% identical to

b0903 pyruvate formate-lyase from Escherichia coli K-12 substr. MG1655
P09373 formate C-acetyltransferase (EC 2.3.1.54) from Escherichia coli
PFams: PFL-like, Gly_radical
760 amino acids: PaperBLAST, CDD