Other Characterized Proteins Similar to yvgN

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to yvgN

Finding the characterized proteins for yvgN (methylglyoxal reductase (NADPH-dependent)) in L-threonine catabolism

Or see clustering for step yvgN

Or see all steps for L-threonine catabolism

Or cluster curated proteins matching a keyword

Definition of yvgN

Curated proteins or TIGRFams with EC 1.1.1.283
Ignore hits to items matching 1.1.1.184 when looking for 'other' hits
Comment: 1.1.1.184 describes relatively non-specific ketone reductases, some of which are related to methylglyoxal reductases and may well have that activity as well.

Fetched 5 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 53 other characterized sequences. (Found 58 hits including self hits.)

Removing ignored items reduces this to 51 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for yvgN.)

Q4DJ07 prostaglandin-F synthase (EC 1.1.1.188) from Trypanosoma cruzi
PFams: Aldo_ket_red
283 amino acids: PaperBLAST, CDD, BRENDA::Q4DJ07
59% identical to

O32210 glyoxal/methylglyoxal reductase (EC 1.1.1.283; EC 1.1.1.91) from Bacillus subtilis (strain 168)
GR_BACSU / O32210 Glyoxal reductase; GR; Methylglyoxal reductase; EC 1.1.1.-; EC 1.1.1.283 from Bacillus subtilis (strain 168)
PFams: Aldo_ket_red
276 amino acids: PaperBLAST, CDD

PGFS_TRYBB / Q9GV41 9,11-endoperoxide prostaglandin H2 reductase; Prostaglandin F2-alpha synthase; EC 1.1.1.- from Trypanosoma brucei brucei
PFams: Aldo_ket_red
276 amino acids: PaperBLAST, CDD, SwissProt::Q9GV41
58% identical to

PGFS_LEIMA / P22045 9,11-endoperoxide prostaglandin H2 reductase; Prostaglandin F2-alpha synthase; EC 1.1.1.- from Leishmania major
P22045 prostaglandin-F synthase (EC 1.1.1.188) from Leishmania major
PFams: Aldo_ket_red
284 amino acids: PaperBLAST, CDD, BRENDA::P22045
58% identical to

ARI1_YEAST / P53111 NADPH-dependent aldehyde reductase ARI1; EC 1.1.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: KR, Epimerase, 3Beta_HSD, GDP_Man_Dehyd, NAD_binding_4
347 amino acids: PaperBLAST, CDD, SwissProt::P53111
56% identical to

Q12068 methylglyoxal reductase (EC 1.1.1.265; EC 1.1.1.283) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
GRE2_YEAST / Q12068 NADPH-dependent methylglyoxal reductase GRE2; 3-methylbutanal reductase; Genes de respuesta a estres protein 2; Isovaleraldehyde reductase; EC 1.1.1.283; EC 1.1.1.265 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Q12068 3-methylbutanal reductase (EC 1.1.1.265); methylglyoxal reductase (NADPH) (EC 1.1.1.283) from Saccharomyces cerevisiae
PFams: Epimerase, 3Beta_HSD
342 amino acids: PaperBLAST, CDD

YGD9_YEAST / P53183 Putative uncharacterized oxidoreductase YGL039W; EC 1.1.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: KR, Epimerase, 3Beta_HSD, GDP_Man_Dehyd, NAD_binding_4
348 amino acids: PaperBLAST, CDD, SwissProt::P53183
56% identical to

CH_123507 potential oxidoreductase from Candida albicans
PFams: Epimerase, 3Beta_HSD, GDP_Man_Dehyd, NAD_binding_10, NAD_binding_4
338 amino acids: PaperBLAST, CDD, CharProtDB::CH_123507
49% identical to

GRP2_CANAL / P83775 Putative NADPH-dependent methylglyoxal reductase GRP2; Cytoplasmic antigenic protein 2; EC 1.1.1.283 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
CH_123670 potential oxidoreductase from Candida albicans
PFams: adh_short, Epimerase, Polysacc_synt_2, 3Beta_HSD, GDP_Man_Dehyd, NAD_binding_4, NAD_binding_10
341 amino acids: PaperBLAST, CDD

CH_000621 organophosphate reductase from Klebsiella sp. F51-1-2
PFams: Aldo_ket_red
283 amino acids: PaperBLAST, CDD, CharProtDB::CH_000621
50% identical to

H9CWC0 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming) (EC 1.1.1.274) from Corynebacterium glutamicum
PFams: Aldo_ket_red
305 amino acids: PaperBLAST, CDD, BRENDA::H9CWC0
48% identical to

CH_122890 potential oxidoreductase from Candida albicans
PFams: Epimerase, NmrA, Polysacc_synt_2, GDP_Man_Dehyd, 3Beta_HSD, NAD_binding_4, NAD_binding_10
345 amino acids: PaperBLAST, CDD, CharProtDB::CH_122890
45% identical to

b3012 methylglyoxal reductase DkgA (EC 1.1.1.346) from Escherichia coli K-12 substr. MG1655
Q46857 methylglyoxal reductase DkgA (EC 1.1.1.346) from Escherichia coli (strain K12)
Q46857 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming) (EC 1.1.1.346) from Escherichia coli
PFams: Aldo_ket_red, Aldo_ket_red
275 amino acids: PaperBLAST, CDD, BRENDA::Q46857
45% identical to

YER5_SCHPO / O14088 Uncharacterized oxidoreductase C2F3.05c; EC 1.-.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: Aldo_ket_red
275 amino acids: PaperBLAST, CDD, SwissProt::O14088
44% identical to

C4R4L0 dihydroflavonol 4-reductase (EC 1.1.1.219) from Komagataella phaffii
PFams: Epimerase, KR, 3Beta_HSD, NAD_binding_4
354 amino acids: PaperBLAST, CDD, BRENDA::C4R4L0
43% identical to

Y2996_MYCBO / Q7TXI6 Uncharacterized oxidoreductase Mb2996; EC 1.-.-.- from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
PFams: Aldo_ket_red
282 amino acids: PaperBLAST, CDD, SwissProt::Q7TXI6
44% identical to

P06632 2,5-diketo-D-gluconate reductase A monomer (EC 1.1.1.346) from Corynebacterium sp. (strain ATCC 31090)
DKGA_CORSC / P06632 2,5-diketo-D-gluconic acid reductase A; 2,5-DKG reductase A; 2,5-DKGR A; 25DKGR-A; AKR5C; EC 1.1.1.346 from Corynebacterium sp. (strain ATCC 31090)
P06632 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming) (EC 1.1.1.346) from Corynebacterium sp.
PFams: Aldo_ket_red
278 amino acids: PaperBLAST, CDD, SwissProt::P06632
43% identical to

Q2TJA5 prostaglandin-F synthase (EC 1.1.1.188) from Sus scrofa
PFams: Aldo_ket_red
322 amino acids: PaperBLAST, CDD, BRENDA::Q2TJA5
42% identical to

Q9XF81 aldehyde reductase (EC 1.1.1.21) from Xerophyta viscosa
PFams: Aldo_ket_red
319 amino acids: PaperBLAST, CDD, BRENDA::Q9XF81
41% identical to

P07943 alcohol dehydrogenase (NADP+) (EC 1.1.1.2); aldehyde reductase (EC 1.1.1.21) from Rattus norvegicus
PFams: Aldo_ket_red
316 amino acids: PaperBLAST, CDD, BRENDA::P07943
42% identical to

COR12_PAPSO / Q9SQ69 NADPH-dependent codeinone reductase 1-2; EC 1.1.1.247 from Papaver somniferum (Opium poppy)
PFams: Aldo_ket_red
321 amino acids: PaperBLAST, CDD, SwissProt::Q9SQ69
43% identical to

ALDR_PIG / P80276 Aldo-keto reductase family 1 member B1; Aldehyde reductase; Aldose reductase; AR; EC 1.1.1.300; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.21 from Sus scrofa (Pig)
PFams: Aldo_ket_red
316 amino acids: PaperBLAST, CDD, SwissProt::P80276
42% identical to

P15121 aldose reductase from Homo sapiens
ALDR_HUMAN / P15121 Aldo-keto reductase family 1 member B1; Aldehyde reductase; Aldose reductase; AR; EC 1.1.1.300; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.21 from Homo sapiens (Human)
P15121 prostaglandin-F synthase (EC 1.1.1.188); aldehyde reductase (EC 1.1.1.21) from Homo sapiens
PFams: Aldo_ket_red
316 amino acids: PaperBLAST, CDD, BRENDA::P15121
42% identical to

AK1A1_RAT / P51635 Aldo-keto reductase family 1 member A1; 3-DG-reducing enzyme; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; EC 1.1.1.2; EC 1.1.1.33; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.19; EC 1.1.1.20 from Rattus norvegicus (Rat)
P51635 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Rattus norvegicus
PFams: Aldo_ket_red
325 amino acids: PaperBLAST, CDD, BRENDA::P51635
42% identical to

P50578 aldehyde reductase (EC 1.1.1.2) from Sus scrofa
AK1A1_PIG / P50578 Aldo-keto reductase family 1 member A1; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; EC 1.1.1.2; EC 1.1.1.33; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.19; EC 1.1.1.20 from Sus scrofa (Pig)
P50578 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Sus scrofa
PFams: Aldo_ket_red
325 amino acids: PaperBLAST, CDD, SwissProt::P50578
42% identical to

Q9SQ67 codeinone reductase (EC 1.1.1.218; EC 1.1.1.247) from Papaver somniferum
COR14_PAPSO / Q9SQ67 NADPH-dependent codeinone reductase 1-4; EC 1.1.1.247 from Papaver somniferum (Opium poppy)
Q9SQ67 codeinone reductase (NADPH) (EC 1.1.1.247) from Papaver somniferum
PFams: Aldo_ket_red
321 amino acids: PaperBLAST, CDD, SwissProt::Q9SQ67
43% identical to

ALDR_MOUSE / P45376 Aldo-keto reductase family 1 member B1; Aldehyde reductase; Aldo-keto reductase family 1 member B3; Aldose reductase; AR; EC 1.1.1.300; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.21 from Mus musculus (Mouse)
P45376 aldehyde reductase (EC 1.1.1.21) from Mus musculus
PFams: Aldo_ket_red
316 amino acids: PaperBLAST, CDD, BRENDA::P45376
42% identical to

COR13_PAPSO / Q9SQ68 NADPH-dependent codeinone reductase 1-3; EC 1.1.1.247 from Papaver somniferum (Opium poppy)
PFams: Aldo_ket_red
321 amino acids: PaperBLAST, CDD, SwissProt::Q9SQ68
42% identical to

COR15_PAPSO / B9VRJ2 NADPH-dependent codeinone reductase 1-5; EC 1.1.1.247 from Papaver somniferum (Opium poppy)
PFams: Aldo_ket_red
321 amino acids: PaperBLAST, CDD, SwissProt::B9VRJ2
42% identical to

Q9JII6 alcohol dehydrogenase [NADP⁺] (EC 1.1.1.19) from Mus musculus
AK1A1_MOUSE / Q9JII6 Aldo-keto reductase family 1 member A1; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; EC 1.1.1.2; EC 1.1.1.33; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.19; EC 1.1.1.20 from Mus musculus (Mouse)
Q540D7 aldehyde dehydrogenase (NADP+) (EC 1.2.1.4) from Mus musculus
Q9JII6 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Mus musculus
PFams: Aldo_ket_red
325 amino acids: PaperBLAST, CDD, BRENDA::Q540D7
41% identical to

AK1A1_HUMAN / P14550 Aldo-keto reductase family 1 member A1; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; EC 1.1.1.2; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1.19; EC 1.1.1.20 from Homo sapiens (Human)
PFams: Aldo_ket_red
325 amino acids: PaperBLAST, CDD, SwissProt::P14550
41% identical to

ALD1_RAT / Q5RJP0 Aldo-keto reductase family 1 member B7; Aldehyde reductase; Aldose reductase-like protein AKR1B14; Aldose reductase-related protein 1; EC 1.1.1.21 from Rattus norvegicus (Rat)
PFams: Aldo_ket_red
316 amino acids: PaperBLAST, CDD, SwissProt::Q5RJP0
41% identical to

DHB5_MOUSE / P70694 Estradiol 17 beta-dehydrogenase 5; 17-beta-HSD 5; EC 1.1.1.- from Mus musculus (Mouse)
PFams: Aldo_ket_red
323 amino acids: PaperBLAST, CDD, SwissProt::P70694
40% identical to

COR11_PAPSO / Q9SQ70 NADPH-dependent codeinone reductase 1-1; EC 1.1.1.247 from Papaver somniferum (Opium poppy)
PFams: Aldo_ket_red
321 amino acids: PaperBLAST, CDD, SwissProt::Q9SQ70
42% identical to

AK1BA_HUMAN / O60218 Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase; EC 1.1.1.300; EC 1.1.1.54 from Homo sapiens (Human)
O60218 aldehyde reductase (EC 1.1.1.21) from Homo sapiens
PFams: Aldo_ket_red
316 amino acids: PaperBLAST, CDD, BRENDA::O60218
41% identical to

P16116 prostaglandin-F synthase (EC 1.1.1.188); aldehyde reductase (EC 1.1.1.21) from Bos taurus
PFams: Aldo_ket_red
315 amino acids: PaperBLAST, CDD, BRENDA::P16116
40% identical to

P31867 NAD(P)H-dependent D-xylose reductase (EC 1.1.1.307) from Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
XYL1_PICST / P31867 NAD(P)H-dependent D-xylose reductase; XR; EC 1.1.1.307 from Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
P31867 D-xylose reductase (EC 1.1.1.307) from Scheffersomyces stipitis
PFams: Aldo_ket_red
318 amino acids: PaperBLAST, CDD, BRENDA::P31867
40% identical to

P82125 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Sus scrofa
AKCL2_PIG / P82125 1,5-anhydro-D-fructose reductase; AF reductase; Aldo-keto reductase family 1 member C-like protein 2; Aldo-keto reductase family 1 member CL2; Aldo-keto reductase family 1 member E2; EC 1.1.1.263 from Sus scrofa (Pig)
PFams: Aldo_ket_red
301 amino acids: PaperBLAST, CDD, SwissProt::P82125
41% identical to

A2T1W7 aldehyde reductase (EC 1.1.1.21) from Zea mays
PFams: Aldo_ket_red
310 amino acids: PaperBLAST, CDD, BRENDA::A2T1W7
41% identical to

AK1C1_MACFU / Q95JH6 Aldo-keto reductase family 1 member C1 homolog; 20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; Dihydrodiol dehydrogenase 1; DD-1; DD1; Indanol dehydrogenase; EC 1.-.-.-; EC 1.1.1.149; EC 1.1.1.112 from Macaca fuscata fuscata (Japanese macaque)
PFams: Aldo_ket_red
323 amino acids: PaperBLAST, CDD, SwissProt::Q95JH6
40% identical to

AK1C1_MACFA / Q95JH7 Aldo-keto reductase family 1 member C1 homolog; 20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; Dihydrodiol dehydrogenase 1; DD-1; DD1; Indanol dehydrogenase; EC 1.-.-.-; EC 1.1.1.149; EC 1.1.1.112 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
PFams: Aldo_ket_red
323 amino acids: PaperBLAST, CDD, SwissProt::Q95JH7
40% identical to

ALD1_MOUSE / P21300 Aldo-keto reductase family 1 member B7; Aldehyde reductase; AR; Aldose reductase-related protein 1; MVDP; Vas deferens androgen-dependent protein; EC 1.1.1.21 from Mus musculus (Mouse)
PFams: Aldo_ket_red
316 amino acids: PaperBLAST, CDD, SwissProt::P21300
40% identical to

AK1CA_RAT / D3ZF77 Aldo-keto reductase family 1 member C15; RAKc; EC 1.1.1.-; EC 1.1.1.216 from Rattus norvegicus (Rat)
PFams: Aldo_ket_red
324 amino acids: PaperBLAST, CDD, SwissProt::D3ZF77
40% identical to

A0MTG4 D-xylose reductase (EC 1.1.1.307) from Scheffersomyces shehatae
PFams: Aldo_ket_red
323 amino acids: PaperBLAST, CDD, BRENDA::A0MTG4
40% identical to

Q0PGJ6 aldo-keto reductase family 4 member C9 (EC 1.1.1.21; EC 1.1.1.210; EC 1.1.1.2; EC 1.1.1.54) from Arabidopsis thaliana
AKRC9_ARATH / Q0PGJ6 NADPH-dependent aldo-keto reductase, chloroplastic; AtChlAKR; Aldo-keto reductase family 4 member C9; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress)
PFams: Aldo_ket_red
315 amino acids: PaperBLAST, CDD, SwissProt::Q0PGJ6
43% identical to

AK1BF_HUMAN / C9JRZ8 Aldo-keto reductase family 1 member B15; Estradiol 17-beta-dehydrogenase AKR1B15; Farnesol dehydrogenase; Testosterone 17beta-dehydrogenase; EC 1.1.1.-; EC 1.1.1.300; EC 1.1.1.54; EC 1.1.1.216; EC 1.1.1.64 from Homo sapiens (Human)
C9JRZ8 acetoacetyl-CoA reductase (EC 1.1.1.36); 17beta-estradiol 17-dehydrogenase (EC 1.1.1.62) from Homo sapiens
PFams: Aldo_ket_red
316 amino acids: PaperBLAST, CDD, SwissProt::C9JRZ8
40% identical to

Q7Z8L1 glycerol dehydrogenase (NADP+) (EC 1.1.1.72) from Aspergillus nidulans
CH_121998 NADP(+)-dependent glycerol dehydrogenase; EC 1.1.1.72 from Emericella nidulans
PFams: Aldo_ket_red
325 amino acids: PaperBLAST, CDD, CharProtDB::CH_121998
40% identical to

D0VDT4 20alpha-hydroxysteroid dehydrogenase (EC 1.1.1.149) from Bos taurus
PFams: Aldo_ket_red
323 amino acids: PaperBLAST, CDD, BRENDA::D0VDT4
40% identical to

O80944 aldo-keto reductase family 4 member C8 (EC 1.1.1.210) from Arabidopsis thaliana
AKRC8_ARATH / O80944 Aldo-keto reductase family 4 member C8; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress)
PFams: Aldo_ket_red
311 amino acids: PaperBLAST, CDD, SwissProt::O80944
40% identical to

AKCL2_MOUSE / Q9DCT1 1,5-anhydro-D-fructose reductase; AF reductase; Aldo-keto reductase family 1 member C-like protein 2; Aldo-keto reductase family 1 member E1; Aldo-keto reductase family 1 member E2; EC 1.1.1.263 from Mus musculus (Mouse)
Q9DCT1 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Mus musculus
PFams: Aldo_ket_red
301 amino acids: PaperBLAST, CDD, BRENDA::Q9DCT1
40% identical to

C1K8Y9 D-xylose reductase (EC 1.1.1.307) from Candida tropicalis
PFams: Aldo_ket_red
324 amino acids: PaperBLAST, CDD, BRENDA::C1K8Y9
40% identical to

A0A0H4J0K0 1,2-dehydroreticuline synthase (EC 1.14.19.54) from Papaver somniferum
PFams: Aldo_ket_red
323 amino acids: PaperBLAST, CDD, BRENDA::A0A0H4J0K0
40% identical to

DMS1B_WHEAT / A0A1D5XGW0 Deoxymugineic acid synthase 1-B; EC 1.1.1.285 from Triticum aestivum (Wheat)
PFams: Aldo_ket_red
314 amino acids: PaperBLAST, CDD, SwissProt::A0A1D5XGW0
40% identical to

DMS1D_WHEAT / A0A1X9QHJ0 Deoxymugineic acid synthase 1-D; EC 1.1.1.285 from Triticum aestivum (Wheat)
PFams: Aldo_ket_red
314 amino acids: PaperBLAST, CDD, SwissProt::A0A1X9QHJ0
40% identical to

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for yvgN.)

E3W861 carbonyl reductase (NADPH) (EC 1.1.1.184) from Bacillus sp. (in: Bacteria)
PFams: Aldo_ket_red
280 amino acids: PaperBLAST, CDD, BRENDA::E3W861
71% identical to

Q5FT75 carbonyl reductase (NADPH) (EC 1.1.1.184) from Gluconobacter oxydans
PFams: Aldo_ket_red
279 amino acids: PaperBLAST, CDD, BRENDA::Q5FT75
44% identical to