GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for acs (acetyl-CoA synthetase, AMP-forming) in thymidine catabolism

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Definition of acs

Fetched 31 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 30 of these sequences

Found 2 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 564-743 amino acids (not heteromeric)

ACSS3_RAT / A0A0G2K047 Acyl-CoA synthetase short-chain family member 3, mitochondrial; Acetate--CoA ligase 3; Acyl-CoA synthetase short-chain family member 3; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Rattus norvegicus (Rat)
A0A0G2K047 propionate-CoA ligase (EC 6.2.1.17) from Rattus norvegicus
PFams: ACAS_N, AMP-binding, AMP-binding_C
683 amino acids: PaperBLAST, CDD, Compare to cluster

A0A144QFN1 acetate-CoA ligase (EC 6.2.1.1) from Dunaliella tertiolecta
PFams: ACAS_N, AMP-binding, AMP-binding_C
727 amino acids: PaperBLAST, CDD, Compare to cluster

ACSA_METTP / A0B8F1 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
A0B8F1 acetate-CoA ligase (EC 6.2.1.1) from Methanothrix thermoacetophila
PFams: ACAS_N, AMP-binding, AMP-binding_C
659 amino acids: PaperBLAST, CDD, Compare to cluster

HBCL1_METS5 / A4YDT1 4-hydroxybutyrate--CoA ligase 1; Acetate--CoA ligase; Butyrate--CoA ligase; Propionate--CoA ligase; EC 6.2.1.40; EC 6.2.1.1; EC 6.2.1.2; EC 6.2.1.17 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
A4YDT1 4-hydroxybutyrate-CoA ligase (EC 6.2.1.40) from Metallosphaera sedula
A4YDT1 4-hydroxybutyryl-CoA synthetase (AMP-forming) (EC 6.2.1.40) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
PFams: AMP-binding, AMP-binding_C
564 amino acids: PaperBLAST, CDD, Compare to cluster

A4YGF9 4-hydroxybutyrate-CoA ligase (EC 6.2.1.40) (from HMM only) from Metallosphaera sedula
PFams: ACAS_N, AMP-binding, AMP-binding_C
664 amino acids: PaperBLAST, CDD, Compare to cluster

HPCAS_METS5 / A4YGR1 3-hydroxypropionyl-coenzyme A synthetase; 3-hydroxypropionyl-CoA synthetase; EC 6.2.1.36 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
A4YGR1 propionate-CoA ligase (EC 6.2.1.17); 3-hydroxypropionyl-CoA synthase (EC 6.2.1.36) from Metallosphaera sedula
A4YGR1 3-hydroxypropionyl-CoA synthetase subunit (EC 6.2.1.36) (from HMM only) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
PFams: ACAS_N, AMP-binding, AMP-binding_C
661 amino acids: PaperBLAST, CDD, Compare to cluster

ACS_ARATH / B9DGD6 Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal; Acetate--CoA ligase; Acetyl-CoA synthetase; EC 6.2.1.1 from Arabidopsis thaliana (Mouse-ear cress)
B9DGD6 acetate-CoA ligase (EC 6.2.1.1) from Arabidopsis thaliana
PFams: ACAS_N, AMP-binding, AMP-binding_C
743 amino acids: PaperBLAST, CDD, Compare to cluster

ACS2_YEAST / P52910 Acetyl-coenzyme A synthetase 2; Acetate--CoA ligase 2; Acyl-activating enzyme 2; EC 6.2.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P52910 acetate-CoA ligase (EC 6.2.1.1) from Saccharomyces cerevisiae
P52910 acetyl CoA synthetase 2 (EC 6.2.1.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
PFams: ACAS_N, AMP-binding, AMP-binding_C
683 amino acids: PaperBLAST, CDD, Compare to cluster

Q2I0L7 acetate-CoA ligase (EC 6.2.1.1) from Methanothermobacter thermautotrophicus
PFams: ACAS_N, AMP-binding, AMP-binding_C
634 amino acids: PaperBLAST, CDD, Compare to cluster

Q2XNL6 acetate-CoA ligase (EC 6.2.1.1) from Methanothermobacter thermautotrophicus
PFams: ACAS_N, AMP-binding, AMP-binding_C
634 amino acids: PaperBLAST, CDD, Compare to cluster

ACS2L_MOUSE / Q99NB1 Acetyl-coenzyme A synthetase 2-like, mitochondrial; Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; AceCS2; Acyl-CoA synthetase short-chain family member 1; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Mus musculus (Mouse)
Q99NB1 acetate-CoA ligase (EC 6.2.1.1) from Mus musculus
PFams: ACAS_N, AMP-binding, AMP-binding_C
682 amino acids: PaperBLAST, CDD, Compare to cluster

ACSA_HUMAN / Q9NR19 Acetyl-coenzyme A synthetase, cytoplasmic; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Homo sapiens (Human)
Q9NR19 acetate-CoA ligase (EC 6.2.1.1) from Homo sapiens
Q9NR19 acetyl-coA synthetase (EC 6.2.1.1) from Homo sapiens
PFams: ACAS_N, AMP-binding, AMP-binding_C
701 amino acids: PaperBLAST, CDD, Compare to cluster

CH_122470 acetyl-coenzyme A synthetase; EC 6.2.1.1 from Emericella nidulans
PFams: ACAS_N, AMP-binding, AMP-binding_C
670 amino acids: PaperBLAST, CDD, Compare to cluster

CH_122700 acetyl-coenzyme A synthetase 2; EC 6.2.1.1 from Candida albicans
PFams: ACAS_N, AMP-binding, AMP-binding_C
671 amino acids: PaperBLAST, CDD, Compare to cluster

b4069 acetyl-CoA synthetase (AMP-forming) (EC 6.2.1.1; EC 6.2.1.17) from Escherichia coli K-12 substr. MG1655
ACSA_ECOLI / P27550 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Escherichia coli (strain K12)
P27550 acetyl-CoA synthetase (AMP-forming) (EC 6.2.1.1; EC 6.2.1.17) from Escherichia coli (strain K12)
PFams: ACAS_N, AMP-binding, AMP-binding_C
652 amino acids: PaperBLAST, CDD, Compare to cluster

ACSA_CUPNH / P31638 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
P31638 acetyl-CoA synthetase (EC 6.2.1.1; EC 6.2.1.17) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
PFams: ACAS_N, AMP-binding, AMP-binding_C
660 amino acids: PaperBLAST, CDD, Compare to cluster

ACSA_BACSU / P39062 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Bacillus subtilis (strain 168)
PFams: AMP-binding, AMP-binding_C
572 amino acids: PaperBLAST, CDD, Compare to cluster

ACSA_MYCTU / P9WQD1 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: ACAS_N, AMP-binding, AMP-binding_C
651 amino acids: PaperBLAST, CDD, Compare to cluster

ACS1_YEAST / Q01574 Acetyl-coenzyme A synthetase 1; Acetate--CoA ligase 1; Acyl-activating enzyme 1; EC 6.2.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Q01574 acetyl CoA synthetase 1 (EC 6.2.1.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
PFams: ACAS_N, AMP-binding, AMP-binding_C
713 amino acids: PaperBLAST, CDD, Compare to cluster

ACSA_SALTY / Q8ZKF6 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: ACAS_N, AMP-binding, AMP-binding_C
652 amino acids: PaperBLAST, CDD, Compare to cluster

HPCAS_SULTO / Q973W5 3-hydroxypropionyl-coenzyme A synthetase; 3-hydroxypropionyl-CoA synthetase; EC 6.2.1.36 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
Q973W5 3-hydroxypropionyl-CoA synthase (EC 6.2.1.36) (from HMM only) from Sulfurisphaera tokodaii
PFams: ACAS_N, AMP-binding, AMP-binding_C
659 amino acids: PaperBLAST, CDD, Compare to cluster

ACSS3_HUMAN / Q9H6R3 Acyl-CoA synthetase short-chain family member 3, mitochondrial; Acetate--CoA ligase 3; Acyl-CoA synthetase short-chain family member 3; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Homo sapiens (Human)
PFams: ACAS_N, AMP-binding, AMP-binding_C
686 amino acids: PaperBLAST, CDD, Compare to cluster

ACS2L_HUMAN / Q9NUB1 Acetyl-coenzyme A synthetase 2-like, mitochondrial; Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; AceCS2; Acyl-CoA synthetase short-chain family member 1; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Homo sapiens (Human)
Q9NUB1 acetate-CoA ligase (EC 6.2.1.1) from Homo sapiens
PFams: ACAS_N, AMP-binding, AMP-binding_C
689 amino acids: PaperBLAST, CDD, Compare to cluster

ACSA_MOUSE / Q9QXG4 Acetyl-coenzyme A synthetase, cytoplasmic; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Mus musculus (Mouse)
PFams: ACAS_N, AMP-binding, AMP-binding_C
701 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_03060 Acetyl-coenzyme A synthetase (EC 6.2.1.1) from Pseudomonas fluorescens FW300-N2E3
PFams: ACAS_N, AMP-binding, AMP-binding_C
651 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_18695 Acetyl-coenzyme A synthetase (EC 6.2.1.1) from Pseudomonas fluorescens FW300-N2C3
PFams: ACAS_N, AMP-binding, AMP-binding_C
651 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 549-573 amino acids (not heteromeric)

HBCL2_METS5 / A4YDR9 4-hydroxybutyrate--CoA ligase 2; Acetate--CoA ligase; Butyrate--CoA ligase; Propionate--CoA ligase; acyl-activating enzyme; EC 6.2.1.40; EC 6.2.1.1; EC 6.2.1.2; EC 6.2.1.17 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
A4YDR9 4-hydroxybutyrate-CoA ligase (EC 6.2.1.40) from Metallosphaera sedula
PFams: AMP-binding, AMP-binding_C
549 amino acids: PaperBLAST, CDD, Compare to cluster

AEE7_ARATH / Q8VZF1 Acetate/butyrate--CoA ligase AAE7, peroxisomal; AMP-binding protein 7; AtAMPBP7; Acetyl-CoA synthetase; Acyl-activating enzyme 7; Butyryl-CoA synthetase; Protein ACETATE NON-UTILIZING 1; EC 6.2.1.1; EC 6.2.1.2 from Arabidopsis thaliana (Mouse-ear cress)
PFams: AMP-binding, AMP-binding_C
569 amino acids: PaperBLAST, CDD, Compare to cluster

M4IRL4 isovalerate--CoA ligase (EC 6.2.1.1) from Humulus lupulus
PFams: AMP-binding, AMP-binding_C
573 amino acids: PaperBLAST, CDD, Compare to cluster

M4IQQ5 isobutanoate/2-methylbutanoate--CoA ligase (EC 6.2.1.1) from Humulus lupulus
PFams: AMP-binding, AMP-binding_C
556 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

ACSA_MYCS2 / A0R5G1 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
PFams: ACAS_N, AMP-binding, AMP-binding_C
940 amino acids: PaperBLAST, CDD