Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for deoA (thymidine phosphorylase DeoA) in thymidine catabolism

Or see other characterized proteins similar to deoA

Or see all steps for thymidine catabolism

Or cluster curated proteins matching a keyword

Definition of deoA

Curated proteins or TIGRFams with EC 2.4.2.2
Curated proteins or TIGRFams with EC 2.4.2.4
Ignore hits to P19663 when looking for 'other' hits (Thymidine phosphorylase; TdRPase; EC 2.4.2.4)
Ignore hits to items matching 2.4.2.3 when looking for 'other' hits
Comment: P19663 is ignored because it is a sequence fragment. Many uridine phosphorylases (EC 2.4.2.3) are also deoxyuridine phosphorylases and thymidine phosphyrylases, so hits to these are ignored.

Fetched 15 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 14 of these sequences

Found 3 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 421-503 amino acids (not heteromeric)

P19971 thymidine phosphorylase monomer (EC 2.4.2.3; EC 2.4.2.2) from Homo sapiens
TYPH_HUMAN / P19971 Thymidine phosphorylase; TP; Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase; EC 2.4.2.4 from Homo sapiens (Human)
P19971 thymidine phosphorylase (EC 2.4.2.4) from Homo sapiens
PFams: Glycos_trans_3N, Glycos_transf_3, PYNP_C
482 amino acids: PaperBLAST, CDD, Compare to cluster

b4382 thymidine phosphorylase (EC 2.4.2.2; EC 2.4.2.4; EC 2.4.2.3) from Escherichia coli K-12 substr. MG1655
P07650 thymidine phosphorylase (EC 2.4.2.2; EC 2.4.2.3) from Escherichia coli (strain K12)
P07650 thymidine phosphorylase (EC 2.4.2.4) from Escherichia coli
GB|AAC77335.1 thymidine phosphorylase; EC 2.4.2.4 from Escherichia coli K12
PFams: Glycos_trans_3N, Glycos_transf_3, PYNP_C
440 amino acids: PaperBLAST, CDD, Compare to cluster

P75052 thymidine phosphorylase (EC 2.4.2.4) from Mycoplasma pneumoniae
PFams: Glycos_trans_3N, Glycos_transf_3, PYNP_C
421 amino acids: PaperBLAST, CDD, Compare to cluster

Q5JCX3 AMP phosphorylase (EC 2.4.2.57) (from HMM only) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
AMPPA_THEKO / Q5JCX3 AMP phosphorylase; AMPpase; Nucleoside monophosphate phosphorylase; NMP phosphorylase; EC 2.4.2.57 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Q5JCX3 AMP phosphorylase (EC 2.4.2.57) from Thermococcus kodakarensis
PFams: Glycos_trans_3N, Glycos_transf_3, PYNP_C
503 amino acids: PaperBLAST, CDD, Compare to cluster

Q5SHF9 pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) from Thermus thermophilus
PFams: Glycos_trans_3N, Glycos_transf_3, PYNP_C
423 amino acids: PaperBLAST, CDD, Compare to cluster

Q7CP66 thymidine phosphorylase (EC 2.4.2.4) from Salmonella enterica subsp. enterica serovar Typhimurium
PFams: Glycos_trans_3N, Glycos_transf_3, PYNP_C
440 amino acids: PaperBLAST, CDD, Compare to cluster

Q99N42 thymidine phosphorylase (EC 2.4.2.4) from Mus musculus
PFams: Glycos_trans_3N, Glycos_transf_3, PYNP_C
471 amino acids: PaperBLAST, CDD, Compare to cluster

PDP_BACSU / P39142 Pyrimidine-nucleoside phosphorylase; PYNP; Py-NPase; EC 2.4.2.2 from Bacillus subtilis (strain 168)
GB|CAB15976.2 pyrimidine-nucleoside phosphorylase; EC 2.4.2.2 from Bacillus subtilis
PFams: Glycos_trans_3N, Glycos_transf_3, PYNP_C
433 amino acids: PaperBLAST, CDD, Compare to cluster

P77836 pyrimidine-nucleoside phosphorylase monomer (EC 2.4.2.3; EC 2.4.2.2) from Geobacillus stearothermophilus
PDP_GEOSE / P77836 Pyrimidine-nucleoside phosphorylase; PYNP; Py-NPase; EC 2.4.2.2 from Geobacillus stearothermophilus (Bacillus stearothermophilus)
GB|BAA13512.1 pyrimidine-nucleoside phosphorylase; EC 2.4.2.2 from Geobacillus stearothermophilus
PFams: Glycos_trans_3N, Glycos_transf_3, PYNP_C
433 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 253-277 amino acids (not heteromeric)

Q5XA29 pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) from Streptococcus pyogenes
PFams: PNP_UDP_1
259 amino acids: PaperBLAST, CDD, Compare to cluster

b3831 uridine phosphorylase (EC 2.4.2.2; EC 2.4.2.3) from Escherichia coli K-12 substr. MG1655
P12758 uridine phosphorylase (EC 2.4.2.2) from Escherichia coli (strain K12)
CH_003939 uridine phosphorylase; EC 2.4.2.3 from Escherichia coli K12
PFams: PNP_UDP_1
253 amino acids: PaperBLAST, CDD, Compare to cluster

Q5JJC1 uridine phosphorylase (EC 2.4.2.2) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
PFams: PNP_UDP_1
277 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 295-310 amino acids (not heteromeric)

Q16831 uridine phosphorylase 1 (EC 2.4.2.3; EC 2.4.2.2) from Homo sapiens
UPP1_HUMAN / Q16831 Uridine phosphorylase 1; UPase 1; UrdPase 1; EC 2.4.2.3 from Homo sapiens (Human)
Q16831 uridine phosphorylase (EC 2.4.2.3) from Homo sapiens
PFams: PNP_UDP_1
310 amino acids: PaperBLAST, CDD, Compare to cluster

UTPP_CAEEL / Q23588 Uridine and thymidine phosphorylase; Pyrimidine-nucleoside phosphorylase; EC 2.4.2.2 from Caenorhabditis elegans
PFams: PNP_UDP_1
295 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

b0391 nucleoside phosphorylase PpnP (EC 2.4.2.15; EC 2.4.2.1; EC 2.4.2.2; EC 2.4.2.4; EC 2.4.2.3) from Escherichia coli K-12 substr. MG1655
P0C037 nucleoside phosphorylase PpnP (EC 2.4.2.15; EC 2.4.2.2; EC 2.4.2.1) from Escherichia coli (strain K12)
PPNP_ECOLI / P0C037 Pyrimidine/purine nucleoside phosphorylase; Adenosine phosphorylase; Cytidine phosphorylase; Guanosine phosphorylase; Inosine phosphorylase; Thymidine phosphorylase; Uridine phosphorylase; Xanthosine phosphorylase; EC 2.4.2.1; EC 2.4.2.2; EC 2.4.2.15; EC 2.4.2.4; EC 2.4.2.3 from Escherichia coli (strain K12)
PFams: Ppnp
94 amino acids: PaperBLAST, CDD