GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for nupC (thymidine permease NupC) in thymidine catabolism

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Definition of nupC

Fetched 2 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 1 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 400-419 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

A0KU05 Nucleoside permease {ECO:0000256|RuleBase:RU362018}; Flags: Precursor
419 amino acids: PaperBLAST, CDD, Compare to cluster

b2393 nucleoside:H+ symporter NupC from Escherichia coli K-12 substr. MG1655
NUPC_ECOLI / P0AFF2 Nucleoside permease NupC; Nucleoside-transport system protein NupC from Escherichia coli (strain K12)
TC 2.A.41.1.1 / P0AFF2 Pyrimidine nucleoside:H+ symporter, NupC (Craig et al. 1994; Patching et al. 2005). Wild-type NupC had an apparent affinity for uridine of 22.2 +/- 3.7 muM and an apparent binding affinity of 1.8-2.6 mM, and various mutants with alterred properties were isolated and characterized (Sun et al. 2017). ADP-glucose is also a substrate of this system from Escherichia coli
P0AFF2 nucleoside:H+ symporter NupC from Escherichia coli (strain K12)
PFams: Nucleos_tra2_N, Gate, Nucleos_tra2_C
400 amino acids: PaperBLAST, CDD, Compare to cluster