Other Characterized Proteins Similar to crr

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to crr

Finding the characterized proteins for crr (glucose PTS, enzyme IIA) in trehalose catabolism

Or see clustering for step crr

Or see all steps for trehalose catabolism

Or cluster curated proteins matching a keyword

Definition of crr

Curated sequence CH_088352: glucose-specific phosphotransferase enzyme IIA component; EC 2.7.1.-. PTS system glucose-specific EIIA component; EIIA-Glc; EIII-Glc; Glucose-specific phosphotransferase enzyme IIA component. Glucose-specific phosphotransferase enzyme IIA component PTGA aka CRR aka GSR aka IEX aka TGS aka TRED aka B2417, component of Glucose porter (PtsG; GlcA; Umg) (transports D-glucose and α-methyl-D-glucopyranoside). Enzyme IIA^Glc (EC 2.7.1.199; EC 2.7.1.201; EC 2.7.1.192). Enzyme IIA^Glc (EC 2.7.1.199)
Curated sequence P0A283: PTS system glucose-specific EIIA component; EIIA-Glc; EIII-Glc; Glucose-specific phosphotransferase enzyme IIA component
Ignore hits to Q8L3C4 when looking for 'other' hits (IIA aka Crr, component of The N,N' -diacetylchitobiose Enzyme II (Toratani et al., 2008) (>80% identical to the E. coli enzyme (4.A.3.2.1)))
Comment: Ignore a close homlog in Serratia (TC 4.A.3.2.5 / Q8L3C4) which is reported to be the II-A component for N,N' -diacetylchitobiose (probably shared with other sugars).

Fetched 2 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 10 other characterized sequences. (Found 12 hits including self hits.)

Removing ignored items reduces this to 9 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for crr.)

P45604 protein-Npi-phosphohistidine-N-acetyl-D-glucosamine phosphotransferase (EC 2.7.1.193) from Klebsiella pneumoniae
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
651 amino acids: PaperBLAST, CDD, BRENDA::P45604
53% identical to

PTGA_SALTY / P0A283 PTS system glucose-specific EIIA component; EIIA-Glc; EIII-Glc; Glucose-specific phosphotransferase enzyme IIA component from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: PTS_EIIA_1
Heteromeric, 169 amino acids: PaperBLAST, CDD

b0679 N-acetylglucosamine-specific PTS enzyme IIABC component (EC 2.7.1.193; EC 2.7.1.191) from Escherichia coli K-12 substr. MG1655
P09323 N-acetylglucosamine-specific PTS enzyme IIABC component (EC 2.7.1.193; EC 2.7.1.191) from Escherichia coli (strain K12)
PTW3C_ECOLI / P09323 PTS system N-acetylglucosamine-specific EIICBA component; EIICBA-Nag; EII-Nag; EC 2.7.1.193 from Escherichia coli (strain K12)
P09323 protein-Npi-phosphohistidine-N-acetyl-D-glucosamine phosphotransferase (EC 2.7.1.193) from Escherichia coli
TC 4.A.1.1.2 / P09323 N-Acetyl glucosamine (NAG) porter (NagE) from Escherichia coli
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
648 amino acids: PaperBLAST, CDD, BRENDA::P09323
51% identical to

TC 4.A.1.1.9 / P20166 The glucose IICBA porter (PtsG) 44% identical to 4.A.1.1.1) from Bacillus subtilis
GB|CAB13262.1 PTS system glucose-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69 from Bacillus subtilis
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
699 amino acids: PaperBLAST, CDD, CharProtDB::CH_001857
43% identical to

PTU3C_STACT / Q53922 PTS system glucoside-specific EIICBA component; EIICBA-Glc 2; EC 2.7.1.- from Staphylococcus carnosus (strain TM300)
TC 4.A.1.1.14 / Q53922 Glucose porter GlcB (IICBA). Glucose uptake is inhibited by methyl-α-D-glucoside, methyl-β-D-glucoside, p-nitrophenyl-α-D-glucoside, o-nitrophenyl-β-D-glucoside and salicin, but not by 2-deoxyglucose. Mannose and N-acetylglucosamine are not transported from Staphylococcus carnosus (strain TM300)
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
692 amino acids: PaperBLAST, CDD, SwissProt::Q53922
42% identical to

PTG3C_STACT / Q57071 PTS system glucose-specific EIICBA component; EIICBA-Glc; EII-Glc; EIICBA-Glc 1; EC 2.7.1.199 from Staphylococcus carnosus (strain TM300)
TC 4.A.1.1.13 / Q57071 Glucose porter, GlcA (IICBA). Glucose uptake is inhibited by 2-deoxyglucose and methyl-β-D-glucoside from Staphylococcus carnosus (strain TM300)
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
675 amino acids: PaperBLAST, CDD, SwissProt::Q57071
40% identical to

Q46072 protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191); protein-Npi-phosphohistidine-D-glucose phosphotransferase (EC 2.7.1.199) from Corynebacterium glutamicum
PFams: PTS_EIIB, PTS_EIIC, PTS_EIIA_1
683 amino acids: PaperBLAST, CDD, BRENDA::Q46072
41% identical to

P12655 protein-Npi-phosphohistidine-sucrose phosphotransferase (EC 2.7.1.211) from Streptococcus mutans serotype c
GB|AAN59464.1 PTS system, sucrose-specific, EIIBCA component; EC 2.7.1.69 from Streptococcus mutans
PFams: PTS_EIIB, PTS_EIIC, PTS_EIIA_1
664 amino acids: PaperBLAST, CDD, BRENDA::P12655
40% identical to

b2417 Enzyme IIA^Glc (EC 2.7.1.199; EC 2.7.1.201; EC 2.7.1.192) from Escherichia coli K-12 substr. MG1655
P69783 Enzyme IIA^Glc (EC 2.7.1.199) from Escherichia coli (strain K12)
PTGA_ECOLI / P69783 PTS system glucose-specific EIIA component; EIIA-Glc; EIII-Glc; Glucose-specific phosphotransferase enzyme IIA component from Escherichia coli (strain K12)
TC 4.A.1.1.1 / P69783 Glucose-specific phosphotransferase enzyme IIA component PTGA aka CRR aka GSR aka IEX aka TGS aka TRED aka B2417, component of Glucose porter (PtsG; GlcA; Umg) (transports D-glucose and α-methyl-D-glucopyranoside) from Escherichia coli
GB|AAC75470.1 glucose-specific phosphotransferase enzyme IIA component; EC 2.7.1.- from Escherichia coli K12
PFams: PTS_EIIA_1
Heteromeric, 169 amino acids: PaperBLAST, CDD

AO356_17540 N-acetylglucosamine-specific PTS system, I, HPr, and IIA components (nagF) from Pseudomonas fluorescens FW300-N2C3
PFams: PTS_EIIA_1, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
Heteromeric, 837 amino acids: PaperBLAST, CDD, reanno::pseudo5_N2C3_1:AO356_17540
40% identical to

PTW3C_BACSU / P39816 Putative PTS system glucosamine-specific EIICBA component; EC 2.7.1.193 from Bacillus subtilis (strain 168)
TC 4.A.1.1.6 / P39816 The glucosamine IICBA porter (GamP) (40% identical to 4.A.1.1.2) (Plumbridge 2015). The IIA domain in this protein can transfer the phosphoryl moiety to the maltose, N-acetylglucosamine, sucrose and trehalose PTS systems (MalP, NagP, SacP and TreP, respectively) from Bacillus subtilis
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
631 amino acids: PaperBLAST, CDD, SwissProt::P39816
47% identical to

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for crr.)

TC 4.A.3.2.5 / Q8L3C4 IIA aka Crr, component of The N,N' -diacetylchitobiose Enzyme II (Toratani et al., 2008) (>80% identical to the E. coli enzyme (4.A.3.2.1)) from Serratia marcescens
PFams: PTS_EIIA_1
Heteromeric, 169 amino acids: PaperBLAST, CDD, TCDB::Q8L3C4
97% identical to