Clusters of Characterized Proteins

Clustering the characterized proteins for malE2 (trehalose ABC transporter, substrate-binding component MalE2) in trehalose catabolism

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Definition of malE2

• Curated sequence Q9S5Y1: MalE2; aka Maltose ABC transporter, periplasmic maltose-binding protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins
• Comment: Thermotoga maritima also has TC 3.A.1.1.22 system with two different SBPs (malE1E2) and also malF1G1G2K These are duplicated operons and probably either paralog will work with either SBP. Only malE2 binds trehalose (PMC1064059). The ATPase component (malK) is quite similar to thuK and was included in that definition

Fetched 1 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 0 of these sequences

Found 0 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Singletons (1/1 heteromeric)

TC 3.A.1.1.22 / Q9S5Y1 MalE2; aka Maltose ABC transporter, periplasmic maltose-binding protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins from Thermotoga maritima
PFams: SBP_bac_1, SBP_bac_8
Heteromeric, 393 amino acids: PaperBLAST, CDD