Other Characterized Proteins Similar to malE2

Finding the characterized proteins for malE2 (trehalose ABC transporter, substrate-binding component MalE2) in trehalose catabolism

Or see clustering for step malE2

Or see all steps for trehalose catabolism

Or cluster curated proteins matching a keyword

Definition of malE2

• Curated sequence Q9S5Y1: MalE2; aka Maltose ABC transporter, periplasmic maltose-binding protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins
• Comment: Thermotoga maritima also has TC 3.A.1.1.22 system with two different SBPs (malE1E2) and also malF1G1G2K These are duplicated operons and probably either paralog will work with either SBP. Only malE2 binds trehalose (PMC1064059). The ATPase component (malK) is quite similar to thuK and was included in that definition

Fetched 1 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 1 other characterized sequences. (Found 2 hits including self hits.)

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for malE2.)

TC 3.A.1.1.22 / Q9X0T1 MalE1; aka Maltose ABC transporter, periplasmic maltose-binding protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins from Thermotoga maritima
PFams: SBP_bac_1, SBP_bac_8
Heteromeric, 391 amino acids: PaperBLAST, CDD, TCDB::Q9X0T1
79% identical to

TC 3.A.1.1.22 / Q9S5Y1 MalE2; aka Maltose ABC transporter, periplasmic maltose-binding protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins from Thermotoga maritima
PFams: SBP_bac_1, SBP_bac_8
Heteromeric, 393 amino acids: PaperBLAST, CDD