Other Characterized Proteins Similar to treEIIA

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to treEIIA

Finding the characterized proteins for treEIIA (N-acetylglucosamine phosphotransferase system, EII-A component (Crr/PtsG/YpqE/GamP)) in trehalose catabolism

Or see clustering for step treEIIA

Or see all steps for trehalose catabolism

Or cluster curated proteins matching a keyword

Definition of treEIIA

Curated sequence P20166: PTS system glucose-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69. The glucose IICBA porter (PtsG) 44% identical to 4.A.1.1.1)
UniProt sequence P50829: RecName: Full=Putative phosphotransferase enzyme IIA component YpqE; AltName: Full=Putative PTS system EIIA component;
Curated sequence P39816: Putative PTS system glucosamine-specific EIICBA component; EC 2.7.1.193. The glucosamine IICBA porter (GamP) (40% identical to 4.A.1.1.2) (Plumbridge 2015). The IIA domain in this protein can transfer the phosphoryl moiety to the maltose, N-acetylglucosamine, sucrose and trehalose PTS systems (MalP, NagP, SacP and TreP, respectively)
Curated sequence CH_088352: glucose-specific phosphotransferase enzyme IIA component; EC 2.7.1.-. PTS system glucose-specific EIIA component; EIIA-Glc; EIII-Glc; Glucose-specific phosphotransferase enzyme IIA component. Glucose-specific phosphotransferase enzyme IIA component PTGA aka CRR aka GSR aka IEX aka TGS aka TRED aka B2417, component of Glucose porter (PtsG; GlcA; Umg) (transports D-glucose and α-methyl-D-glucopyranoside). Enzyme IIA^Glc (EC 2.7.1.199; EC 2.7.1.201; EC 2.7.1.192). Enzyme IIA^Glc (EC 2.7.1.199)
Ignore hits to P0A283 when looking for 'other' hits (PTS system glucose-specific EIIA component; EIIA-Glc; EIII-Glc; Glucose-specific phosphotransferase enzyme IIA component)
Ignore hits to Q8L3C4 when looking for 'other' hits (IIA aka Crr, component of The N,N' -diacetylchitobiose Enzyme II (Toratani et al., 2008) (>80% identical to the E. coli enzyme (4.A.3.2.1)))
Curated sequence GFF4500: D-trehalose PTS system, I, HPr, and IIA components
Curated sequence AO353_15995: trehalose-specific PTS system, I, HPr, and IIA components
Comment: Ignore a close homlog in Serratia (TC 4.A.3.2.5 / Q8L3C4) which is reported to be the II-A component, and the homolog in Salmonella. Include E. coli crr and B. subtilis ptsG, gamP, or ptsA (PMC6148471).

Fetched 6 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 32 other characterized sequences. (Found 37 hits including self hits.)

Removing ignored items reduces this to 30 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for treEIIA.)

PTG3C_STACT / Q57071 PTS system glucose-specific EIICBA component; EIICBA-Glc; EII-Glc; EIICBA-Glc 1; EC 2.7.1.199 from Staphylococcus carnosus (strain TM300)
TC 4.A.1.1.13 / Q57071 Glucose porter, GlcA (IICBA). Glucose uptake is inhibited by 2-deoxyglucose and methyl-β-D-glucoside from Staphylococcus carnosus (strain TM300)
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
675 amino acids: PaperBLAST, CDD, SwissProt::Q57071
58% identical to

TC 4.A.1.1.9 / P20166 The glucose IICBA porter (PtsG) 44% identical to 4.A.1.1.1) from Bacillus subtilis
GB|CAB13262.1 PTS system glucose-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69 from Bacillus subtilis
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
699 amino acids: PaperBLAST, CDD

PTU3C_STACT / Q53922 PTS system glucoside-specific EIICBA component; EIICBA-Glc 2; EC 2.7.1.- from Staphylococcus carnosus (strain TM300)
TC 4.A.1.1.14 / Q53922 Glucose porter GlcB (IICBA). Glucose uptake is inhibited by methyl-α-D-glucoside, methyl-β-D-glucoside, p-nitrophenyl-α-D-glucoside, o-nitrophenyl-β-D-glucoside and salicin, but not by 2-deoxyglucose. Mannose and N-acetylglucosamine are not transported from Staphylococcus carnosus (strain TM300)
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
692 amino acids: PaperBLAST, CDD, SwissProt::Q53922
56% identical to

P45604 protein-Npi-phosphohistidine-N-acetyl-D-glucosamine phosphotransferase (EC 2.7.1.193) from Klebsiella pneumoniae
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
651 amino acids: PaperBLAST, CDD, BRENDA::P45604
52% identical to

b2417 Enzyme IIA^Glc (EC 2.7.1.199; EC 2.7.1.201; EC 2.7.1.192) from Escherichia coli K-12 substr. MG1655
P69783 Enzyme IIA^Glc (EC 2.7.1.199) from Escherichia coli (strain K12)
PTGA_ECOLI / P69783 PTS system glucose-specific EIIA component; EIIA-Glc; EIII-Glc; Glucose-specific phosphotransferase enzyme IIA component from Escherichia coli (strain K12)
TC 4.A.1.1.1 / P69783 Glucose-specific phosphotransferase enzyme IIA component PTGA aka CRR aka GSR aka IEX aka TGS aka TRED aka B2417, component of Glucose porter (PtsG; GlcA; Umg) (transports D-glucose and α-methyl-D-glucopyranoside) from Escherichia coli
GB|AAC75470.1 glucose-specific phosphotransferase enzyme IIA component; EC 2.7.1.- from Escherichia coli K12
PFams: PTS_EIIA_1
Heteromeric, 169 amino acids: PaperBLAST, CDD

TC 4.A.1.1.15 / Q9HXN5 N-Acetyl-D-Glucosamine phosphotransferase system transporter, component of N-acetyl glucosamine-specific PTS permease, GlcNAc IIBC/GlcNAc I-HPr-IIA from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
PFams: PTS_EIIA_1, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
Heteromeric, 842 amino acids: PaperBLAST, CDD, TCDB::Q9HXN5
46% identical to

PS417_23035 D-trehalose PTS system, I, HPr, and IIA components from Pseudomonas simiae WCS417
PFams: PTS_EIIA_1, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
Heteromeric, 838 amino acids: PaperBLAST, CDD

AO353_04460 N-acetylglucosamine-specific PTS system, I, HPr, and IIA components (nagF) from Pseudomonas fluorescens FW300-N2E3
PFams: PTS_EIIA_1, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
Heteromeric, 838 amino acids: PaperBLAST, CDD, reanno::pseudo3_N2E3:AO353_04460
46% identical to

AO356_17540 N-acetylglucosamine-specific PTS system, I, HPr, and IIA components (nagF) from Pseudomonas fluorescens FW300-N2C3
PFams: PTS_EIIA_1, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
Heteromeric, 837 amino acids: PaperBLAST, CDD, reanno::pseudo5_N2C3_1:AO356_17540
44% identical to

b0679 N-acetylglucosamine-specific PTS enzyme IIABC component (EC 2.7.1.193; EC 2.7.1.191) from Escherichia coli K-12 substr. MG1655
P09323 N-acetylglucosamine-specific PTS enzyme IIABC component (EC 2.7.1.193; EC 2.7.1.191) from Escherichia coli (strain K12)
PTW3C_ECOLI / P09323 PTS system N-acetylglucosamine-specific EIICBA component; EIICBA-Nag; EII-Nag; EC 2.7.1.193 from Escherichia coli (strain K12)
P09323 protein-Npi-phosphohistidine-N-acetyl-D-glucosamine phosphotransferase (EC 2.7.1.193) from Escherichia coli
TC 4.A.1.1.2 / P09323 N-Acetyl glucosamine (NAG) porter (NagE) from Escherichia coli
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
648 amino acids: PaperBLAST, CDD, BRENDA::P09323
49% identical to

BPHYT_RS02740 N-acetylglucosamine-specific PTS system, I, HPr, and IIA components (nagF) from Burkholderia phytofirmans PsJN
PFams: PTS_EIIA_1, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
Heteromeric, 854 amino acids: PaperBLAST, CDD, reanno::BFirm:BPHYT_RS02740
43% identical to

TC 4.A.1.2.11 / P40739 Aryl β-glucoside porter, IIBCA (BglP; SytA) (35% identical to 4.A.1.2.2) from Bacillus subtilis
PFams: PTS_EIIB, PTS_EIIC, PTS_EIIA_1
609 amino acids: PaperBLAST, CDD, TCDB::P40739
51% identical to

P50829 Putative phosphotransferase enzyme IIA component YpqE; Putative PTS system EIIA component
168 amino acids: PaperBLAST, CDD

TC 4.A.1.1.11 / Q8DS05 The maltose/maltotriose porter, MalT (31% identical to 4.A.1.1.9) from Streptococcus mutans
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
729 amino acids: PaperBLAST, CDD, TCDB::Q8DS05
45% identical to

P50829 Putative phosphotransferase enzyme IIA component YpqE; Putative PTS system EIIA component
168 amino acids: PaperBLAST, CDD

TC 4.A.2.1.17 / Q9HY55 Phosphotransferase system transporter enzyme I, FruI, component of Fructose-specific PTS permease, FruIIBC/FruI-HPr-IIA from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
PFams: PTS_EIIA_2, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
Heteromeric, 956 amino acids: PaperBLAST, CDD, TCDB::Q9HY55
46% identical to

TC 4.A.1.1.12 / Q48WG5 Maltose/Maltotriose PTS transporter, MalT (Shelburne et al., 2008) 631aas (68% identical to 4.A.1.1.11 from S. mutans from Streptococcus pyogenes serotype M1
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
631 amino acids: PaperBLAST, CDD, TCDB::Q48WG5
40% identical to

P50829 Putative phosphotransferase enzyme IIA component YpqE; Putative PTS system EIIA component
168 amino acids: PaperBLAST, CDD

AO353_04465 N-acetylglucosamine-specific PTS system, IIBC components (nagE) from Pseudomonas fluorescens FW300-N2E3
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIB
Heteromeric, 571 amino acids: PaperBLAST, CDD, reanno::pseudo3_N2E3:AO353_04465
47% identical to

PTW3C_BACSU / P39816 Putative PTS system glucosamine-specific EIICBA component; EC 2.7.1.193 from Bacillus subtilis (strain 168)
TC 4.A.1.1.6 / P39816 The glucosamine IICBA porter (GamP) (40% identical to 4.A.1.1.2) (Plumbridge 2015). The IIA domain in this protein can transfer the phosphoryl moiety to the maltose, N-acetylglucosamine, sucrose and trehalose PTS systems (MalP, NagP, SacP and TreP, respectively) from Bacillus subtilis
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
631 amino acids: PaperBLAST, CDD

PS417_03965 Phosphoenolpyruvate--protein phosphotransferase (EC 2.7.3.9) from Pseudomonas simiae WCS417
PFams: PTS_EIIA_2, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
952 amino acids: PaperBLAST, CDD, reanno::WCS417:GFF780
45% identical to

AO356_07335 Phosphoenolpyruvate--protein phosphotransferase (EC 2.7.3.9) from Pseudomonas fluorescens FW300-N2C3
PFams: PTS_EIIA_2, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
954 amino acids: PaperBLAST, CDD, reanno::pseudo5_N2C3_1:AO356_07335
44% identical to

Psest_3355 Phosphoenolpyruvate--protein phosphotransferase (EC 2.7.3.9) from Pseudomonas stutzeri RCH2
PFams: PTS_EIIA_2, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
960 amino acids: PaperBLAST, CDD, reanno::psRCH2:GFF3291
44% identical to

BPHYT_RS02745 N-acetylglucosamine-specific PTS system, IIBC components (nagE) from Burkholderia phytofirmans PsJN
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIB
Heteromeric, 591 amino acids: PaperBLAST, CDD, reanno::BFirm:BPHYT_RS02745
47% identical to

Pf1N1B4_1146 Phosphoenolpyruvate--protein phosphotransferase (EC 2.7.3.9) from Pseudomonas fluorescens FW300-N1B4
PFams: PTS_EIIA_2, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
953 amino acids: PaperBLAST, CDD, reanno::pseudo1_N1B4:Pf1N1B4_1146
44% identical to

Q46072 protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191); protein-Npi-phosphohistidine-D-glucose phosphotransferase (EC 2.7.1.199) from Corynebacterium glutamicum
PFams: PTS_EIIB, PTS_EIIC, PTS_EIIA_1
683 amino acids: PaperBLAST, CDD, BRENDA::Q46072
40% identical to

PTGCB_SALTY / P37439 PTS system glucose-specific EIICB component; EIICB-Glc; EII-Glc; EC 2.7.1.199 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: PTS_EIIC, PTS_EIIB
477 amino acids: PaperBLAST, CDD, SwissProt::P37439
48% identical to

P12655 protein-Npi-phosphohistidine-sucrose phosphotransferase (EC 2.7.1.211) from Streptococcus mutans serotype c
GB|AAN59464.1 PTS system, sucrose-specific, EIIBCA component; EC 2.7.1.69 from Streptococcus mutans
PFams: PTS_EIIB, PTS_EIIC, PTS_EIIA_1
664 amino acids: PaperBLAST, CDD, BRENDA::P12655
40% identical to

AO356_17535 N-acetylglucosamine-specific PTS system, IIBC components (nagE) from Pseudomonas fluorescens FW300-N2C3
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIB
Heteromeric, 571 amino acids: PaperBLAST, CDD, reanno::pseudo5_N2C3_1:AO356_17535
47% identical to

b1101 glucose-specific PTS enzyme IIBC component (EC 2.7.1.199) from Escherichia coli K-12 substr. MG1655
P69786 glucose-specific PTS enzyme IIBC component (EC 2.7.1.199) from Escherichia coli (strain K12)
PTGCB_ECOLI / P69786 PTS system glucose-specific EIICB component; EIICB-Glc; EII-Glc; EC 2.7.1.199 from Escherichia coli (strain K12)
P69786 protein-Npi-phosphohistidine-D-glucose phosphotransferase (EC 2.7.1.199) from Escherichia coli
TC 4.A.1.1.1 / P69786 PTS system glucose-specific EIICB component PTGB aka PTSG aka GLCA aka UMG aka B1101, component of Glucose porter (PtsG; GlcA; Umg) (transports D-glucose and α-methyl-D-glucopyranoside) from Escherichia coli
MB|P69786 PTS system glucose-specific EIICB component; EC 2.7.1.69 from Escherichia coli K12
PFams: PTS_EIIC, PTS_EIIB
Heteromeric, 477 amino acids: PaperBLAST, CDD, BRENDA::P69786
48% identical to

AO353_05485 Fructose-specific PTS system, I, HPr, and IIA components from Pseudomonas fluorescens FW300-N2E3
PFams: PTS_EIIA_2, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
Heteromeric, 953 amino acids: PaperBLAST, CDD, reanno::pseudo3_N2E3:AO353_05485
45% identical to

TC 4.A.1.2.16 / ART98386 PTS beta-glucoside transporter, EIIBCA of 647 aas and 10 predicted TMSs from Lactobacillus gasseri
PFams: PTS_EIIB, PTS_EIIC, PTS_EIIA_1
647 amino acids: PaperBLAST, CDD, TCDB::ART98386
45% identical to

P50829 Putative phosphotransferase enzyme IIA component YpqE; Putative PTS system EIIA component
168 amino acids: PaperBLAST, CDD

TC 4.A.1.1.15 / Q9HXN4 N-Acetyl-D-Glucosamine phosphotransferase system transporter, component of N-acetyl glucosamine-specific PTS permease, GlcNAc IIBC/GlcNAc I-HPr-IIA from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIB
Heteromeric, 570 amino acids: PaperBLAST, CDD, TCDB::Q9HXN4
47% identical to

AZOBR_RS32325 Fructose PTS system (E-I, HPr, and E-IIA components) from Azospirillum brasilense Sp245
PFams: PTS_EIIA_2, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
Heteromeric, 846 amino acids: PaperBLAST, CDD, reanno::azobra:AZOBR_RS32325
42% identical to

PTFAX_XANCP / P45597 Multiphosphoryl transfer protein; MTP; Triphosphoryl transfer protein; TTP; EC 2.7.3.9 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
PFams: PTS_EIIA_2, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
838 amino acids: PaperBLAST, CDD, SwissProt::P45597
44% identical to

TC 4.A.1.1.18 / O51590 Glucose-specific Enzyme IIBC of the PTS, PtsG from Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
PFams: PTS_EIIC, PTS_EIIB
514 amino acids: PaperBLAST, CDD, TCDB::O51590
44% identical to

PTWCB_BACSU / O34521 PTS system N-acetylglucosamine-specific EIICB component; EIICB-Nag; EC 2.7.1.- from Bacillus subtilis (strain 168)
TC 4.A.1.1.7 / O34521 The N-acetylglucosamine IICB porter (NagP; YflF) (45% identical to 4.A.1.1.2) from Bacillus subtilis
PFams: PTS_EIIC, PTS_EIIB
452 amino acids: PaperBLAST, CDD, SwissProt::O34521
42% identical to

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for treEIIA.)

PTGA_SALTY / P0A283 PTS system glucose-specific EIIA component; EIIA-Glc; EIII-Glc; Glucose-specific phosphotransferase enzyme IIA component from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: PTS_EIIA_1
Heteromeric, 169 amino acids: PaperBLAST, CDD, SwissProt::P0A283
98% identical to

TC 4.A.3.2.5 / Q8L3C4 IIA aka Crr, component of The N,N' -diacetylchitobiose Enzyme II (Toratani et al., 2008) (>80% identical to the E. coli enzyme (4.A.3.2.1)) from Serratia marcescens
PFams: PTS_EIIA_1
Heteromeric, 169 amino acids: PaperBLAST, CDD, TCDB::Q8L3C4
96% identical to