Clusters of Characterized Proteins

Clustering the characterized proteins for treEIIA (N-acetylglucosamine phosphotransferase system, EII-A component (Crr/PtsG/YpqE/GamP)) in trehalose catabolism

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Definition of treEIIA

• Curated sequence P20166: PTS system glucose-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69. The glucose IICBA porter (PtsG) 44% identical to 4.A.1.1.1)
• UniProt sequence P50829: RecName: Full=Putative phosphotransferase enzyme IIA component YpqE; AltName: Full=Putative PTS system EIIA component;
• Curated sequence P39816: Putative PTS system glucosamine-specific EIICBA component; EC 2.7.1.193. The glucosamine IICBA porter (GamP) (40% identical to 4.A.1.1.2) (Plumbridge 2015). The IIA domain in this protein can transfer the phosphoryl moiety to the maltose, N-acetylglucosamine, sucrose and trehalose PTS systems (MalP, NagP, SacP and TreP, respectively)
• Curated sequence CH_088352: glucose-specific phosphotransferase enzyme IIA component; EC 2.7.1.-. PTS system glucose-specific EIIA component; EIIA-Glc; EIII-Glc; Glucose-specific phosphotransferase enzyme IIA component. Glucose-specific phosphotransferase enzyme IIA component PTGA aka CRR aka GSR aka IEX aka TGS aka TRED aka B2417, component of Glucose porter (PtsG; GlcA; Umg) (transports D-glucose and α-methyl-D-glucopyranoside). Enzyme IIA^Glc (EC 2.7.1.199; EC 2.7.1.201; EC 2.7.1.192). Enzyme IIA^Glc (EC 2.7.1.199)
• Ignore hits to P0A283 when looking for 'other' hits (PTS system glucose-specific EIIA component; EIIA-Glc; EIII-Glc; Glucose-specific phosphotransferase enzyme IIA component)
• Ignore hits to Q8L3C4 when looking for 'other' hits (IIA aka Crr, component of The N,N' -diacetylchitobiose Enzyme II (Toratani et al., 2008) (>80% identical to the E. coli enzyme (4.A.3.2.1)))
• Curated sequence GFF4500: D-trehalose PTS system, I, HPr, and IIA components
• Curated sequence AO353_15995: trehalose-specific PTS system, I, HPr, and IIA components
• Comment: Ignore a close homlog in Serratia (TC 4.A.3.2.5 / Q8L3C4) which is reported to be the II-A component, and the homolog in Salmonella. Include E. coli crr and B. subtilis ptsG, gamP, or ptsA (PMC6148471).

Fetched 6 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 6 of these sequences

Found 3 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 168-169 amino acids (1/2 heteromeric)

b2417 Enzyme IIA^Glc (EC 2.7.1.199; EC 2.7.1.201; EC 2.7.1.192) from Escherichia coli K-12 substr. MG1655
P69783 Enzyme IIA^Glc (EC 2.7.1.199) from Escherichia coli (strain K12)
PTGA_ECOLI / P69783 PTS system glucose-specific EIIA component; EIIA-Glc; EIII-Glc; Glucose-specific phosphotransferase enzyme IIA component from Escherichia coli (strain K12)
TC 4.A.1.1.1 / P69783 Glucose-specific phosphotransferase enzyme IIA component PTGA aka CRR aka GSR aka IEX aka TGS aka TRED aka B2417, component of Glucose porter (PtsG; GlcA; Umg) (transports D-glucose and α-methyl-D-glucopyranoside) from Escherichia coli
GB|AAC75470.1 glucose-specific phosphotransferase enzyme IIA component; EC 2.7.1.- from Escherichia coli K12
PFams: PTS_EIIA_1
Heteromeric, 169 amino acids: PaperBLAST, CDD, Compare to cluster

P50829 Putative phosphotransferase enzyme IIA component YpqE; Putative PTS system EIIA component
168 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 631-699 amino acids (not heteromeric)

TC 4.A.1.1.9 / P20166 The glucose IICBA porter (PtsG) 44% identical to 4.A.1.1.1) from Bacillus subtilis
GB|CAB13262.1 PTS system glucose-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69 from Bacillus subtilis
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
699 amino acids: PaperBLAST, CDD, Compare to cluster

PTW3C_BACSU / P39816 Putative PTS system glucosamine-specific EIICBA component; EC 2.7.1.193 from Bacillus subtilis (strain 168)
TC 4.A.1.1.6 / P39816 The glucosamine IICBA porter (GamP) (40% identical to 4.A.1.1.2) (Plumbridge 2015). The IIA domain in this protein can transfer the phosphoryl moiety to the maltose, N-acetylglucosamine, sucrose and trehalose PTS systems (MalP, NagP, SacP and TreP, respectively) from Bacillus subtilis
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
631 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 838-844 amino acids (heteromeric)

PS417_23035 D-trehalose PTS system, I, HPr, and IIA components from Pseudomonas simiae WCS417
PFams: PTS_EIIA_1, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
Heteromeric, 838 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_15995 trehalose-specific PTS system, I, HPr, and IIA components from Pseudomonas fluorescens FW300-N2E3
PFams: PTS_EIIA_1, PTS-HPr, PEP-utilisers_N, PEP-utilizers, PEP-utilizers_C
Heteromeric, 844 amino acids: PaperBLAST, CDD, Compare to cluster