Other Characterized Proteins Similar to MCT10

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to MCT10

Finding the characterized proteins for MCT10 (L-tyrosine transporter MCT10) in L-tyrosine catabolism

Or see clustering for step MCT10

Or see all steps for L-tyrosine catabolism

Or cluster curated proteins matching a keyword

Definition of MCT10

Curated sequence Q91Y77: Monocarboxylate transporter 10; MCT 10; Aromatic amino acid transporter 1; Solute carrier family 16 member 10; T-type amino acid transporter 1. The low affinity aromatic amino acid (Tyr, Trp, Phe) transporter, TAT1 (T-type amino acid transporter), MCT10, Slc16a10

Fetched 1 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 8 other characterized sequences. (Found 9 hits including self hits.)

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for MCT10.)

MOT10_MOUSE / Q3U9N9 Monocarboxylate transporter 10; MCT 10; Aromatic amino acid transporter 1; Solute carrier family 16 member 10; T-type amino acid transporter 1 from Mus musculus (Mouse)
PFams: MFS_1, MFS_1, MFS_4
512 amino acids: PaperBLAST, CDD, SwissProt::Q3U9N9
91% identical to

MOT10_RAT / Q91Y77 Monocarboxylate transporter 10; MCT 10; Aromatic amino acid transporter 1; Solute carrier family 16 member 10; T-type amino acid transporter 1 from Rattus norvegicus (Rat)
TC 2.A.1.13.2 / Q91Y77 The low affinity aromatic amino acid (Tyr, Trp, Phe) transporter, TAT1 (T-type amino acid transporter), MCT10, Slc16a10 from Rattus norvegicus (Rat)
PFams: MFS_1, MFS_4, MFS_1
514 amino acids: PaperBLAST, CDD

MOT10_HUMAN / Q8TF71 Monocarboxylate transporter 10; MCT 10; Aromatic amino acid transporter 1; Solute carrier family 16 member 10; T-type amino acid transporter 1 from Homo sapiens (Human)
TC 2.A.1.13.8 / Q8TF71 Monocarboxylate transporter, MCT10. Transports thyroid horomones as well as aromatic amino acids from Homo sapiens
PFams: MFS_1, MFS_1
515 amino acids: PaperBLAST, CDD, SwissProt::Q8TF71
84% identical to

TC 2.A.1.13.24 / E1BZU1 MCT10 (SLC16A10) of 400 aas and 11 TMSs from Gallus gallus
PFams: MFS_1, MFS_1
400 amino acids: PaperBLAST, CDD, TCDB::E1BZU1
69% identical to

MOT8_HUMAN / P36021 Monocarboxylate transporter 8; MCT 8; Monocarboxylate transporter 7; MCT 7; Solute carrier family 16 member 2; X-linked PEST-containing transporter from Homo sapiens (Human)
TC 2.A.1.13.10 / P36021 MCT8 (SLC16a2) homodimeric monocarboxylate thyroid hormone transporter 8 from Homo sapiens
PFams: MFS_1, MFS_1
539 amino acids: PaperBLAST, CDD, SwissProt::P36021
52% identical to

MOT8_RAT / Q8K1P8 Monocarboxylate transporter 8; MCT 8; Solute carrier family 16 member 2 from Rattus norvegicus (Rat)
PFams: MFS_1, MFS_1
545 amino acids: PaperBLAST, CDD, SwissProt::Q8K1P8
52% identical to

TC 2.A.1.13.3 / O70324 The thyroid hormone transporter, MCT8 (transports L- and D-isomers of thyroxine (T4), 3,3',5-triiodothyronine (T3), 3,3'5'-triiodothyronine (rT3) and 3,3'-diiodothyronine [Km values = 2-5 μM; Leu, Phe, Trp and Tyr were not transported]) (Friesema et al., 2003). Loss of function mutations in MCT8 leads to Allan-Herndon-Dudley syndrome, severe X-linked psychomotor retardation and elevated serum T3 levels (Jansen et al., 2008). Essential molecular determinants for thyroid hormone transport and their structural implications are presented by Kinne et al. (2010). Induced by retinoic acid (Kogai et al., 2010). Mediates energy-independent bidirectional transport. MCT8 is specific for L-iodothyronines and requires at least one iodine atom per aromatic ring. Thyronamines, decarboxylated metabolites of iodothyronines, triiodothyroacetic acid and tetraiodothyroacetic acid, TH derivatives lacking both chiral center and amino group, are not substrates (Kinne et al., 2010). A deficiency causes altered thyroid morphology and a persistent high triiodothyronine/thyroxine ratio after thyroidectomy (Wirth et al., 2011). Primary and secondary thyroid hormone transporters have been reviewed from Mus musculus (Mouse)
PFams: MFS_1, MFS_1
545 amino acids: PaperBLAST, CDD, TCDB::O70324
51% identical to

TC 2.A.1.13.25 / L7T0T8 Thyroid hormones (TH) transporter, MCT8 of 526 aas and 12 TMSs (Zada et al. 2017). The mechanisms underlying MCT8-deficient brain development in various animal models including zebra fish and humans has been reviewed from Danio rerio
PFams: MFS_1, MFS_1
526 amino acids: PaperBLAST, CDD, TCDB::L7T0T8
54% identical to

TC 2.A.1.13.23 / E1C3S1 Chicken MCT8 of 509 aas and 12 TMSs from Gallus gallus
PFams: MFS_1
509 amino acids: PaperBLAST, CDD, TCDB::E1C3S1
48% identical to