Other Characterized Proteins Similar to HDOP-hydrol

Finding the characterized proteins for HDOP-hydrol (5-hydroxy-2,4-dioxopentanonate hydrolase) in D-xylose catabolism

Or see clustering for step HDOP-hydrol

Or see all steps for D-xylose catabolism

Or cluster curated proteins matching a keyword

Definition of HDOP-hydrol

• UniProt sequence A0A2E7P912: SubName: Full=FAA hydrolase family protein {ECO:0000313|EMBL:MBO18215.1};
• Ignore hits to BPHYT_RS34210 when looking for 'other' hits (2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-))
• Ignore hits to SM_b21112 when looking for 'other' hits (L-2,4-diketo-3-deoxyrhamnonate hydrolase; 2,4-dioxopentanoate hydrolase)
• Comment: C785_RS20550 = WP_039788920.1 = A0A2E7P912 is the HDOP hydrolase (PMC6336799). This enzyme is also similar to SM_b21112, thought to be L-2,4-diketo-3-deoxyrhamnonate hydrolase and 2,4-dioxopentanoate hydrolase; it is plausible that SM_b21112 acts on HDOP as well. Similarly for BPHYT_RS34210 (thought to act on 2,4-diketo-3-deoxy-L-fuconate = L-2,4-diketo-3-deoxyrhamnonate). Both of these homologs are ignored.

Fetched 1 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 5 other characterized sequences. (Found 5 hits including self hits.)

Removing ignored items reduces this to 3 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for HDOP-hydrol.)

UGL_BURL3 / Q39BA7 Ureidoglycolate lyase; UGL; Ureidoglycolase; Ureidoglycolatase; Ureidoglycolate hydrolase; EC 4.3.2.3 from Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
PFams: FAA_hydrolase
282 amino acids: PaperBLAST, CDD, SwissProt::Q39BA7
70% identical to

A0A2E7P912 FAA hydrolase family protein
281 amino acids: PaperBLAST, CDD

Q1NEI7 L-2-keto-3-deoxyrhamnonate 4-dehydrogenase subunit (EC 1.1.1.401) from Sphingomonas sp. (strain SKA58)
PFams: FAA_hydrolase
285 amino acids: PaperBLAST, CDD, metacyc::MONOMER-16233
56% identical to

A0A2E7P912 FAA hydrolase family protein
281 amino acids: PaperBLAST, CDD

FAHD1_ARATH / Q93ZE5 Probable acylpyruvase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; EC 3.7.1.5 from Arabidopsis thaliana (Mouse-ear cress)
PFams: FAA_hydrolase
223 amino acids: PaperBLAST, CDD, SwissProt::Q93ZE5
41% identical to

A0A2E7P912 FAA hydrolase family protein
281 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for HDOP-hydrol.)

BPHYT_RS34210 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-) from Burkholderia phytofirmans PsJN
PFams: FAA_hydrolase
282 amino acids: PaperBLAST, CDD, reanno::BFirm:BPHYT_RS34210
77% identical to

A0A2E7P912 FAA hydrolase family protein
281 amino acids: PaperBLAST, CDD

SM_b21112 L-2,4-diketo-3-deoxyrhamnonate hydrolase; 2,4-dioxopentanoate hydrolase from Sinorhizobium meliloti 1021
PFams: FAA_hydrolase
281 amino acids: PaperBLAST, CDD, reanno::Smeli:SM_b21112
63% identical to

A0A2E7P912 FAA hydrolase family protein
281 amino acids: PaperBLAST, CDD