>TCDB::Q92911 Sodium iodide symporter (NIS; also transports other monovalent anions including: ClO3-, SCN-, SeCN-, NO3-, Br-, BF4-, IO4- and BrO3-). It mediates electroneutral active transport of the environmental pollutant perchlorate (Dohan et al., 2007). Five beta-OH group-containing residues (Thr-351, Ser-353, Thr-354, Ser-356, and Thr-357) and Asn-360, all of which putatively face the same side of the helix in TMS IX, plus Asp-369, located in the membrane/cytosol interface, play key roles in NIS function and seem to be involved in Na+ binding/translocation (De la Vieja et al. 2007). Thr-354 is essential for iodide uptake (Tatsumi et al., 2010). The stoichiometry is Na+:I-= 2:1. The G39R mutant (congenital) is inactive. G93 is a pivot for the inwardly to outwardly conformational change MEAVETGERPTFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAEDFFTGGRRLAALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSVLTALLFMPVFYRLGLTSTYEYLEMRFSRAVRLCGTLQYIVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVVVMLSGFWVVLARGVMLVGGPRQVLTLAQNHSRINLMDFNPDPRSRYTFWTFVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALLINQVGLFLIVSSAACCGIVMFVFYTDCDPLLLGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLRSLAPRKLVIISKGLSLIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPTNEDRLFFLGQKELEGAGSWTPCVGHDGGRDQQETNL >SwissProt::Q47CW6 Perchlorate reductase subunit alpha; Perchlorate reductase molybdenum subunit; EC 1.97.1.- MVQMTRRGFLLASGATLLGSSLSFRTLAAAADLSGAFEYSGWENFHRAQWSWDKKTRGAHLINCTGACPHFVYSKEGVVIREEQSKDIAPMTGIPEYNPRGCNKGECAHDYMYGPHRLKYPLIRVGERGEGKWRRASWDEALDMIADKVVDTIKNHAPDCISVYSPVPAVAPVSFSAGHRFAHYIGAHTHTFFDWYGDHPTGQTQTCGVQGDTAETADWFNSKYIILWGANPTQTRIPDAHFLSEAQLNGTKIVSIAPDFNSSAIKVDKWIHPQPGTDGALALSMAHVIIKEKLYDAHNLKEQTDLSYLVRSDTKRFLREADVVAGGSKDKFYLWDVRTGKPVIPKGCWGDQPEQKAPPVAFMGRNTNTFPKGYIDLGDIDPALEGKFKIQLLDGKSIEVRPVFEILKSRIMADNTPEKAAKITGVPAKSITELAREYATAKPSMIICGGGTQHWYYSDVLLRAMHLLTALTGSEGKNGGGLNHYIGQWKPTFLPGLVALAFPEGPAKQRFCQTTIWTYIHAEVNDQILNSDVDTEKYLREAFASRQMPNLPRDGRDPKVFIIYRGNWLNQAKGQKYVLRNLWPKLELVVDINIRMDSTALYSDVVLPSAHWYEKLDLNVTEEHTFINMTEPAIKPMWESKTDWQIFLALSKRVEMAANRKGYQKFNDEQFKWVRNLSNLWNQMTMDGKLAEDAAAAQYILDNAPHSKGITLDMLREKPQRFKANWTSSMKEGVPYTPFQNFVVDKKPWPTLTGRQQFYLDHETFFDMGVELPVYKAPIDADKYPFRFNSPHSRHSIHSTFKDSVLMLRLQRGGPSIDISSIDAKTLGIKDNDWVEVWNDHGKVICRVKIRSGEQRGRVSMWHTPELYMDLIEGGSQSVCPVRITPTHLVGNYGHLVFRPNYYGPGGTQRDVRVNMKRYIGATPMSF >SwissProt::Q47CW7 Perchlorate reductase subunit beta; Perchlorate reductase iron-sulfur subunit MANVMKAPKRQLTYVTDLNKCIGCQTCTVACKKLWTTGPGQDFMYWRNVETTPGLGYPRNWQTKGGGYKNGELQKGKIPPMIDYGIPFEFDYAGRLFEGKKERVRPSPTPRSAPNWDEDQGAGEYPNNSFFYLPRMCNHCTKPACLEACPNEAIYKREQDGIVVIHQDKCKGAQACVQSCPYAKPYFNPVANKANKCIGCFPRIEQGVAPGCVAQCVGRAMHVGFIDDTNSSVHKLIRLYKVALPLHPEFGTEPNVFYVPPVLGPRMELPNGELSTDPKIPLAQLEGLFGKQVRDVLAILQTEREKKMKGLASDLMDVLIGRRSADMMISPLT >SwissProt::Q47CW8 Perchlorate reductase subunit gamma; Perchlorate reductase heme subunit MIKILALATLLISGFLPGVTVAQQAEYLGFRACTKCHDSQGETWRASAHAKAFDSLKPNAKSEAKTKAKLDPKKDYTQDKNCVGCHVTGYGEPGGFVSGASLDDMKTLVGVTCESCHGAGGKFRNLHGEASDRLKNQGETSERKQLVTAGQNFDMEKACARCHLNFEGSTKHDAKAPFTPFSPSVGSKYQFDFQKSVMTTGAGNPIHTHFKLRGVFKGDPVPAVRAKLQEDAPEPE >biolip::5ch7B Crystal structure of the perchlorate reductase pcrab - phe164 gate switch intermediate - from azospira suillum ps MKAPRRQLTYVTDLNKCIGCQTCTVACKKLWTTGPGQDFMYWRNVETAPGLGYPRNWQTKGGGYKNGELQKGKIPPMIDYGIPFEFDYAGRLFEGKPGRVRPSPTPRSAPNWDEDQGAGEYPNNSFFYLPRMCNHCTKPACLEACPNEAIYKREQDGIVVIHQDKCKGAQACVQSCPYAKPYFNPLTNKANKCIGCFPRIEQGVAPACVAQCVGRAMHVGFVDDVNSSVYKLIKQYKVALPLHPEFGTEPNVFYVPPVLGPRIEMANGEPSTDPKIPLAQLEGLFGKQVRDVLAILQSEREKKMKGLASDLMDVLIGRRSTDMMISPLT >biolip::5chcA Crystal structure of the perchlorate reductase pcrab - substrate analog seo3 bound - from azospira suillum ps ISGAFEYSGWENFHRTQWSWDKKTRGAHLVNCTGACPHFVYSKDGVVMREEQSKDIAPMPNIPEYNPRGCNKGECGHDYMYGPHRIKYPLIRVGERGEGKWRRATWEEALDMIADKCVDTIKNHAPDCISVYSPVPAVSPVSFSAGHRFAHYIGAHAHTFYDWYGDHPTGQTQTCGVQGDTCETADWFNSKYIILWGSNPTQTRIPDAHFLSEAQLNGAKIVSISPDYNSSTIKVDKWIHPQPGTDGALAMAMAHVIIKEKLYDAHSLKEQTDLSYLVRSDTKRFLREADVVAGGSKDKFYFWNAKTGKPVIPKGSWGDQPEKKGSPVGFLGRNTFAFPKGYIDLGDLDPALEGKFNMQLLDGKTVEVRPVFEILKSRLMADNTPEKAAKITGVTAKAITELAREFATAKPSMIICGGGTQHWYYSDVLLRAMHLLTALTGTEGTNGGGMNHYIGQWKPAFVAGLVALAFPEGVNKQRFCQTTIWTYIHAEVNDEIISSDIDTEKYLRDSITTGQMPNMPEQGRDPKVFFVYRGNWLNQAKGQKYVLENLWPKLELIVDINIRMDSTALYSDVVLPSAHWYEKLDLNVTSEHSYINMTEPAIKPMWESKTDWQIFLALAKRVEMAAKRKKYEKFNDEKFKWVRDLSNLWNQMTMDGKLAEDEAAAQYILDNAPQSKGITIQMLREKPQRFKSNWTSPLKEGVPYTPFQYFVVDKKPWPTLTGRQQFYLDHDTFFDMGVELPTYKAPIDADKYPFRFNSPHSRHSVHSTFKDNVLMLRLQRGGPSIEMSPLDAKPLGIKDNDWVEAWNNHGKVICRVKIRNGEQRGRVSMWHCPELYMDLLTGGSQSVCPVRINPTNLVGNYGHLFFRPNYYGPAGSQRDVRVNVKRYIGATPISF >metacyc::MONOMER-15702 perchlorate reductase β subunit MSNMTKSPKRQLAYVADLNKCIGCQTCTVACKTLWTSGPGQDYMYWRNVETAPGLGYPRNWQSKGGGYKDGVLQKGKIPPMIDYGVPFEFDYAGRLFEGKKERARPSPTPRYAPNWDEDQGAGEYPNNSFFYVPRMCNHCAKPACLEACPNEAIYKREQDGLVVIHQEKCKGAQACIQSCPYAKPYFNAQVNKANKCIGCFPRIEKGVAPACVAECAGRAMHVGFIDDQESSVFKLVKRFGVALPLHPEYGTEPNVFYVPPVLGPRVEMPNGEHTADPKISMTQLEQLFGKQVREVLKTLQAEREKKIKNQPSELMDILIGRRSADMMISPMT >metacyc::MONOMER-15703 perchlorate reductase α subunit MARLSRRDFLKASAATLLGNSLTFKTLAATMDLSGAFEYSGWENFHRNQWSWDKKTRGAHLINCTGACPHFVYTKDGVVIREEQSKDIPPMPNIPELNPRGCNKGECAHHYMYGPHRLKYPLIRVGERGEGKWRRATWEEALDLISDKIIDTIKNHSPDCISVYSPLPGTAPVSFSAGHRFAHYIGAHTHTFFDWYSDHPTGQTQTCGVQGDSAECSDWFNSKYIILWGANPTQTRIPDAHFLSEAQLNGAKVVSISPDFNSSTIKADRWIHPLPGTDGALALAMAHVIIKEKLYDAHNLKEQTDLPYLIRRDTKRFLREADVVAGGSKDKFYIWDSKTGKPVITKGSWGDQPEQKAPPVAFMGRNTHTFPKGYIALENLDPALEGKFQVKLQDGNTVEVRPVFEILKSRIEADNNIAKAAKITGVPAKTIIEVAREYATTQPAMIICGGGTMHWYYSDVLLRAMHLLTALVGSEGKNGGGMNHYIGQWKPVFLPGVAALAFPEGPANERSCQTTIWTYIHAEVNDEMANVGIDTDKYLMHAIDTRQMPNYPRDGRDPKVFIVYRGNWLNQAKGQKYVLRNLWPKLDLIVDINIRMDSTALYSDVVLPSAHWYEKLDLNVTAEHTYINMTEPAIKPMWESKTDWQIFLALAKRVEMSAKRKSFERFYDEQFKWARDLTNLWNQMTMDGKLAEDEAAAQYILDTAPHSKGITLQMLREKGERFKANWTSPMKEGVPYTPFQNYIVDKKPWPTLTGRQQFYLDHEVFFEMGVELPTYKAPVDADKFPFRFNSPHSRHSIHSTFKDSVLMLRLQRGGPCVEISPIDATAIGVKDNDWVEIWNSHGKVICRAKIRAGEQRGRVSMWHTPELYMDLLEGSTQSVCPVRITPTHLVGNYGHLVFRPNYYGPAGSQRDVRVDVKRYIGATPISL