Align 4-hydroxybenzoyl-CoA reductase subunit beta; 4-HBCR subunit beta; EC 1.3.7.9 (characterized)
to candidate WP_004301651.1 C665_RS05010 4-hydroxybenzoyl-CoA reductase subunit beta
Query= SwissProt::O33820 (324 letters) >NCBI__GCF_000310185.1:WP_004301651.1 Length = 324 Score = 520 bits (1340), Expect = e-152 Identities = 251/322 (77%), Positives = 281/322 (87%) Query: 1 MNILTDFRTHRPATLADAVNALAAEATLPLGAGTDLLPNLRRGLGHPAALVDLTGIDGLA 60 MNIL DFRTHRPATLADAV+ALAA+ +PL AGTDLLPNLRRGLG PA LVDLTGI GL Sbjct: 1 MNILADFRTHRPATLADAVSALAADGAVPLAAGTDLLPNLRRGLGQPAVLVDLTGIGGLE 60 Query: 61 TISTLADGSLRIGAGATLEAIAEHDAIRTTWPALAQAAESVAGPTHRAAATLGGNLCQDT 120 TIS LADGSLRIGAGATLEAIAEH +R WPALA+AA +VAGPTHRAAATLGGNLCQDT Sbjct: 61 TISILADGSLRIGAGATLEAIAEHGLVRNAWPALAEAAAAVAGPTHRAAATLGGNLCQDT 120 Query: 121 RCTFYNQSEWWRSGNGYCLKYKGDKCHVIVKSDRCYATYHGDVAPALMVLDARAEIVGPA 180 RC FYNQSEWWR+GNGYCLKY+GDKCHVIVK+DRCYATYHGDVAPALMVL AR EI GPA Sbjct: 121 RCIFYNQSEWWRAGNGYCLKYQGDKCHVIVKNDRCYATYHGDVAPALMVLGARVEIAGPA 180 Query: 181 GKRTVPVAQLFRESGAEHLTLEKGELLAAIEVPPTGAWSAAYSKVRIRDAVDFPLAGVAA 240 G+R++ V +LFRE GA HL+L +GEL+ A+EVPP W Y+K RIRDAVDFPLAGVA Sbjct: 181 GRRSLAVEELFREDGAGHLSLGRGELVVAVEVPPASGWRTVYAKARIRDAVDFPLAGVAV 240 Query: 241 ALQRDGDRIAGLRVAITGSNSAPLMVPVDALLGGNWDDAAAETLAQLVRKTSNVLRTTIT 300 AL+RDGDR+AGL+VAITG+NSAPL VP D L+GG WD AAAETL+QLVRKTSNVL+TT+T Sbjct: 241 ALRRDGDRVAGLKVAITGTNSAPLRVPTDELVGGRWDAAAAETLSQLVRKTSNVLKTTVT 300 Query: 301 GVKYRRRVLLAISRKVVDQLWE 322 GV YRRRVLLA++ + VD LW+ Sbjct: 301 GVGYRRRVLLALAPRTVDALWQ 322 Lambda K H 0.319 0.133 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 456 Number of extensions: 7 Number of successful extensions: 1 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 324 Length of database: 324 Length adjustment: 28 Effective length of query: 296 Effective length of database: 296 Effective search space: 87616 Effective search space used: 87616 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 48 (23.1 bits)
This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory