| Pathway | Step | Score | Similar to | Id. | Cov. | Bits | Other hit | Other id. | Other bits |
|---|
| putrescine catabolism | potA | med | spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 (characterized) | 44% | 87% | 257.3 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| sucrose catabolism | thuK | med | ABC transporter (characterized, see rationale) | 41% | 82% | 240 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-glucosamine (chitosamine) catabolism | SM_b21216 | med | ABC transporter for D-Glucosamine, ATPase component (characterized) | 47% | 73% | 230.7 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-maltose catabolism | malK_Bb | med | ABC-type maltose transport, ATP binding protein (characterized, see rationale) | 48% | 70% | 229.6 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| xylitol catabolism | Dshi_0546 | med | ABC transporter for Xylitol, ATPase component (characterized) | 42% | 97% | 228.4 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-cellobiose catabolism | gtsD | med | Sugar ABC transporter ATP-binding protein (characterized, see rationale) | 42% | 79% | 226.5 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-glucose catabolism | gtsD | med | Sugar ABC transporter ATP-binding protein (characterized, see rationale) | 42% | 79% | 226.5 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| lactose catabolism | gtsD | med | Sugar ABC transporter ATP-binding protein (characterized, see rationale) | 42% | 79% | 226.5 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-maltose catabolism | gtsD | med | Sugar ABC transporter ATP-binding protein (characterized, see rationale) | 42% | 79% | 226.5 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| sucrose catabolism | gtsD | med | Sugar ABC transporter ATP-binding protein (characterized, see rationale) | 42% | 79% | 226.5 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| trehalose catabolism | gtsD | med | Sugar ABC transporter ATP-binding protein (characterized, see rationale) | 42% | 79% | 226.5 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| lactose catabolism | lacK | med | ABC transporter for Lactose, ATPase component (characterized) | 40% | 92% | 224.9 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-sorbitol (glucitol) catabolism | mtlK | med | ABC transporter for D-Sorbitol, ATPase component (characterized) | 40% | 91% | 224.9 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-maltose catabolism | malK1 | med | MalK; aka Sugar ABC transporter, ATP-binding protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins (characterized) | 42% | 78% | 221.9 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| trehalose catabolism | thuK | med | MalK; aka Sugar ABC transporter, ATP-binding protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins (characterized) | 42% | 78% | 221.9 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-galactose catabolism | PfGW456L13_1897 | med | ABC transporter for D-Galactose and D-Glucose, ATPase component (characterized) | 42% | 79% | 221.5 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| N-acetyl-D-glucosamine catabolism | SMc02869 | med | N-Acetyl-D-glucosamine ABC transport system, ATPase component (characterized) | 42% | 86% | 221.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-glucosamine (chitosamine) catabolism | SMc02869 | med | N-Acetyl-D-glucosamine ABC transport system, ATPase component (characterized) | 42% | 86% | 221.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-maltose catabolism | malK | med | ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) (characterized) | 42% | 76% | 219.2 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-fucose catabolism | SM_b21106 | med | ABC transporter for L-Fucose, ATPase component (characterized) | 40% | 80% | 218.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-mannitol catabolism | mtlK | med | MtlK, component of The polyol (mannitol, glucitol (sorbitol), arabitol (arabinitol; lyxitol)) uptake porter, MtlEFGK (characterized) | 44% | 79% | 213.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-maltose catabolism | thuK | med | ThuK aka RB0314 aka SMB20328, component of Trehalose/maltose/sucrose porter (trehalose inducible) (characterized) | 44% | 71% | 211.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-cellobiose catabolism | SMc04256 | med | ABC transporter for D-Cellobiose and D-Salicin, ATPase component (characterized) | 43% | 70% | 208 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-maltose catabolism | musK | med | ABC-type maltose transporter (EC 7.5.2.1) (characterized) | 41% | 76% | 203.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-histidine catabolism | Ac3H11_2560 | med | ABC transporter for L-Histidine, ATPase component (characterized) | 42% | 87% | 158.7 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-arginine catabolism | artP | med | Arginine transport ATP-binding protein ArtP; EC 7.4.2.- (characterized) | 40% | 96% | 146 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-xylose catabolism | gtsD | lo | ABC transporter for D-Glucose-6-Phosphate, ATPase component (characterized) | 38% | 92% | 223.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-arabinose catabolism | xacJ | lo | Xylose/arabinose import ATP-binding protein XacJ; EC 7.5.2.13 (characterized, see rationale) | 38% | 93% | 222.2 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-maltose catabolism | aglK | lo | ABC transporter for D-Maltose and D-Trehalose, ATPase component (characterized) | 38% | 96% | 218.4 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| sucrose catabolism | aglK | lo | ABC transporter for D-Maltose and D-Trehalose, ATPase component (characterized) | 38% | 96% | 218.4 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| trehalose catabolism | aglK | lo | ABC transporter for D-Maltose and D-Trehalose, ATPase component (characterized) | 38% | 96% | 218.4 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| xylitol catabolism | HSERO_RS17020 | lo | ABC-type sugar transport system, ATPase component protein (characterized, see rationale) | 46% | 67% | 214.9 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-mannose catabolism | TT_C0211 | lo | Sugar-binding transport ATP-binding protein aka MalK1 aka TT_C0211, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose (characterized) | 38% | 94% | 214.2 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-arabinose catabolism | xacK | lo | Xylose/arabinose import ATP-binding protein XacK; EC 7.5.2.13 (characterized, see rationale) | 37% | 90% | 210.7 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-cellobiose catabolism | msiK | lo | MsiK protein, component of The cellobiose/cellotriose (and possibly higher cellooligosaccharides), CebEFGMsiK [MsiK functions to energize several ABC transporters including those for maltose/maltotriose and trehalose] (characterized) | 37% | 93% | 206.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| trehalose catabolism | treV | lo | TreV, component of Trehalose porter (characterized) | 39% | 86% | 204.9 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-cellobiose catabolism | aglK' | lo | Maltose/maltodextrin import ATP-binding protein; EC 3.6.3.19 (characterized, see rationale) | 36% | 95% | 201.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-glucose catabolism | aglK' | lo | Maltose/maltodextrin import ATP-binding protein; EC 3.6.3.19 (characterized, see rationale) | 36% | 95% | 201.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| lactose catabolism | aglK' | lo | Maltose/maltodextrin import ATP-binding protein; EC 3.6.3.19 (characterized, see rationale) | 36% | 95% | 201.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-maltose catabolism | aglK' | lo | Maltose/maltodextrin import ATP-binding protein; EC 3.6.3.19 (characterized, see rationale) | 36% | 95% | 201.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| sucrose catabolism | aglK' | lo | Maltose/maltodextrin import ATP-binding protein; EC 3.6.3.19 (characterized, see rationale) | 36% | 95% | 201.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| trehalose catabolism | aglK' | lo | Maltose/maltodextrin import ATP-binding protein; EC 3.6.3.19 (characterized, see rationale) | 36% | 95% | 201.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-maltose catabolism | malK_Aa | lo | ABC-type maltose transporter (EC 7.5.2.1) (characterized) | 43% | 64% | 201.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| trehalose catabolism | malK | lo | MsmK aka SMU.882, component of The raffinose/stachyose transporter, MsmEFGK (MalK (3.A.1.1.27) can probably substitute for MsmK; Webb et al., 2008). This system may also transport melibiose, isomaltotriose and sucrose as well as isomaltosaccharides (characterized) | 36% | 80% | 199.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-maltose catabolism | malK_Sm | lo | MalK, component of Maltose/Maltotriose/maltodextrin (up to 7 glucose units) transporters MalXFGK (MsmK (3.A.1.1.28) can probably substitute for MalK; Webb et al., 2008) (characterized) | 37% | 79% | 193.7 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-arabinose catabolism | araV | lo | AraV, component of Arabinose, fructose, xylose porter (characterized) | 35% | 78% | 189.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-fructose catabolism | araV | lo | AraV, component of Arabinose, fructose, xylose porter (characterized) | 35% | 78% | 189.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| sucrose catabolism | araV | lo | AraV, component of Arabinose, fructose, xylose porter (characterized) | 35% | 78% | 189.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-xylose catabolism | araV | lo | AraV, component of Arabinose, fructose, xylose porter (characterized) | 35% | 78% | 189.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| glycerol catabolism | glpT | lo | GlpT, component of Glycerol uptake porter, GlpSTPQV (characterized) | 39% | 76% | 178.3 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-glucosamine (chitosamine) catabolism | AO353_21725 | lo | ABC transporter for D-glucosamine, ATPase component (characterized) | 38% | 92% | 168.3 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-proline catabolism | opuBA | lo | BilEA aka OpuBA protein, component of A proline/glycine betaine uptake system. Also reported to be a bile exclusion system that exports oxgall and other bile compounds, BilEA/EB or OpuBA/BB (required for normal virulence) (characterized) | 33% | 100% | 166 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-asparagine catabolism | bgtA | lo | ATPase (characterized, see rationale) | 40% | 92% | 163.3 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-aspartate catabolism | bgtA | lo | ATPase (characterized, see rationale) | 40% | 92% | 163.3 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-proline catabolism | proV | lo | Glycine betaine/proline betaine transport system ATP-binding protein ProV (characterized) | 36% | 60% | 161.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-asparagine catabolism | glnQ | lo | Glutamine ABC transporter ATP-binding protein, component of Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding both substrate and the transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains (SBDs) differ in substrate specificity and affinity, allowing cells to efficiently accumulate different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate affinity (characterized) | 39% | 97% | 161 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-glutamate catabolism | gltL | lo | Glutamine ABC transporter ATP-binding protein, component of Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding both substrate and the transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains (SBDs) differ in substrate specificity and affinity, allowing cells to efficiently accumulate different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate affinity (characterized) | 39% | 97% | 161 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-histidine catabolism | bgtA | lo | BgtA aka SLR1735, component of Arginine/lysine/histidine/glutamine porter (characterized) | 36% | 96% | 159.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-lysine catabolism | hisP | lo | BgtA aka SLR1735, component of Arginine/lysine/histidine/glutamine porter (characterized) | 36% | 96% | 159.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-histidine catabolism | aapP | lo | ABC transporter for L-Glutamine, L-Histidine, and other L-amino acids, ATPase component (characterized) | 39% | 88% | 158.7 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-histidine catabolism | hutV | lo | ABC transporter for L-Histidine, ATPase component (characterized) | 37% | 82% | 158.7 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-proline catabolism | hutV | lo | HutV aka HISV aka R02702 aka SMC00670, component of Uptake system for hisitidine, proline, proline-betaine and glycine-betaine (characterized) | 37% | 87% | 157.9 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-asparagine catabolism | aatP | lo | ABC transporter for L-asparagine and L-glutamate, ATPase component (characterized) | 39% | 91% | 156.4 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-aspartate catabolism | aatP | lo | ABC transporter for L-asparagine and L-glutamate, ATPase component (characterized) | 39% | 91% | 156.4 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-asparagine catabolism | bztD | lo | BztD, component of Glutamate/glutamine/aspartate/asparagine porter (characterized) | 36% | 91% | 156 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-aspartate catabolism | bztD | lo | BztD, component of Glutamate/glutamine/aspartate/asparagine porter (characterized) | 36% | 91% | 156 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-alanine catabolism | Pf6N2E2_5405 | lo | ABC transporter for D-Alanine, ATPase component (characterized) | 36% | 94% | 152.9 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-histidine catabolism | BPHYT_RS24015 | lo | ABC transporter related (characterized, see rationale) | 38% | 95% | 152.5 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-asparagine catabolism | aapP | lo | AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) (characterized) | 36% | 89% | 152.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-aspartate catabolism | aapP | lo | AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) (characterized) | 36% | 89% | 152.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-glutamate catabolism | aapP | lo | AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) (characterized) | 36% | 89% | 152.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-leucine catabolism | aapP | lo | AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) (characterized) | 36% | 89% | 152.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-proline catabolism | aapP | lo | AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) (characterized) | 36% | 89% | 152.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-histidine catabolism | hisP | lo | Probable ATP-binding component of ABC transporter, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR (characterized) | 37% | 97% | 151 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-citrulline catabolism | AO353_03040 | lo | ABC transporter for L-Arginine and L-Citrulline, ATPase component (characterized) | 35% | 98% | 147.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-citrulline catabolism | PS417_17605 | lo | ATP-binding cassette domain-containing protein; SubName: Full=Amino acid transporter; SubName: Full=Histidine ABC transporter ATP-binding protein; SubName: Full=Histidine transport system ATP-binding protein (characterized, see rationale) | 35% | 90% | 145.6 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-asparagine catabolism | peb1C | lo | PEB1C, component of Uptake system for glutamate and aspartate (characterized) | 33% | 98% | 143.3 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-aspartate catabolism | peb1C | lo | PEB1C, component of Uptake system for glutamate and aspartate (characterized) | 33% | 98% | 143.3 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-isoleucine catabolism | livG | lo | ABC transporter ATP-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM (characterized) | 34% | 93% | 137.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-leucine catabolism | livG | lo | ABC transporter ATP-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM (characterized) | 34% | 93% | 137.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-valine catabolism | livG | lo | ABC transporter ATP-binding protein-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM (characterized) | 34% | 93% | 137.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-proline catabolism | HSERO_RS00895 | lo | ABC-type branched-chain amino acid transport system, ATPase component protein (characterized, see rationale) | 33% | 95% | 133.3 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-phenylalanine catabolism | livG | lo | ABC transporter ATP-binding protein (characterized, see rationale) | 34% | 90% | 132.9 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-serine catabolism | Ac3H11_1693 | lo | ABC transporter ATP-binding protein (characterized, see rationale) | 34% | 90% | 132.9 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-tyrosine catabolism | Ac3H11_1693 | lo | ABC transporter ATP-binding protein (characterized, see rationale) | 34% | 90% | 132.9 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-tryptophan catabolism | ecfA2 | lo | Energy-coupling factor transporter ATP-binding protein EcfA2; Short=ECF transporter A component EcfA2; EC 7.-.-.- (characterized, see rationale) | 36% | 77% | 125.9 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-arabinose catabolism | xylGsa | lo | Xylose/arabinose import ATP-binding protein XylG; EC 7.5.2.13 (characterized, see rationale) | 34% | 98% | 120.2 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| L-tryptophan catabolism | ecfA1 | lo | Energy-coupling factor transporter ATP-binding protein EcfA1; Short=ECF transporter A component EcfA; EC 7.-.-.- (characterized, see rationale) | 34% | 74% | 119.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| citrate catabolism | fecE | lo | iron(III) dicitrate transport ATP-binding protein FecE (characterized) | 32% | 98% | 110.9 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-cellobiose catabolism | mglA | lo | glucose transporter, ATPase component (characterized) | 31% | 87% | 107.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-glucose catabolism | mglA | lo | glucose transporter, ATPase component (characterized) | 31% | 87% | 107.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| lactose catabolism | mglA | lo | glucose transporter, ATPase component (characterized) | 31% | 87% | 107.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-maltose catabolism | mglA | lo | glucose transporter, ATPase component (characterized) | 31% | 87% | 107.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| sucrose catabolism | mglA | lo | glucose transporter, ATPase component (characterized) | 31% | 87% | 107.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| trehalose catabolism | mglA | lo | glucose transporter, ATPase component (characterized) | 31% | 87% | 107.8 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| myo-inositol catabolism | PGA1_c07320 | lo | Inositol transport system ATP-binding protein (characterized) | 33% | 91% | 105.5 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-fructose catabolism | frcA | lo | Fructose import ATP-binding protein FrcA; EC 7.5.2.- (characterized) | 32% | 85% | 102.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-mannose catabolism | frcA | lo | Fructose import ATP-binding protein FrcA; EC 7.5.2.- (characterized) | 32% | 85% | 102.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| D-ribose catabolism | frcA | lo | Fructose import ATP-binding protein FrcA; EC 7.5.2.- (characterized) | 32% | 85% | 102.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
| sucrose catabolism | frcA | lo | Fructose import ATP-binding protein FrcA; EC 7.5.2.- (characterized) | 32% | 85% | 102.1 | CysA aka B2422, component of Sulfate/thiosulfate porter | 62% | 339.3 |
This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using
ublast (a fast alternative to protein BLAST)
against a database of manually-curated proteins (most of which are experimentally characterized) or by using
HMMer with enzyme models (usually from
TIGRFam). Ublast hits may be split across two different proteins.
Steps with no high- or medium-confidence candidates may be considered "gaps."
For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways.
For diverse bacteria and archaea that can utilize a carbon source, there is a complete
high-confidence catabolic pathway (including a transporter) just 38% of the time, and
there is a complete medium-confidence pathway 63% of the time.
Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know