| Pathway | Step | Score | Similar to | Id. | Cov. | Bits | Other hit | Other id. | Other bits |
|---|
| L-proline catabolism | opuBA | med | BusAA, component of Uptake system for glycine-betaine (high affinity) and proline (low affinity) (OpuAA-OpuABC) or BusAA-ABC of Lactococcus lactis). BusAA, the ATPase subunit, has a C-terminal tandem cystathionine β-synthase (CBS) domain which is the cytoplasmic K+ sensor for osmotic stress (osmotic strength)while the BusABC subunit has the membrane and receptor domains fused to each other (Biemans-Oldehinkel et al., 2006; Mahmood et al., 2006; Gul et al. 2012). An N-terminal amphipathic α-helix of OpuA is necessary for high activity but is not critical for biogenesis or the ionic regulation of transport (characterized) | 46% | 96% | 340.9 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-proline catabolism | proV | med | Glycine betaine/proline betaine transport system ATP-binding protein ProV (characterized) | 43% | 99% | 331.3 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-histidine catabolism | hutV | med | ABC transporter for L-Histidine, ATPase component (characterized) | 57% | 98% | 320.1 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-proline catabolism | hutV | med | HutV aka HISV aka R02702 aka SMC00670, component of Uptake system for hisitidine, proline, proline-betaine and glycine-betaine (characterized) | 53% | 96% | 289.3 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-glutamate catabolism | gltL | med | GluA aka CGL1950, component of Glutamate porter (characterized) | 42% | 94% | 163.7 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-arginine catabolism | artP | med | Arginine transport ATP-binding protein ArtM (characterized) | 41% | 98% | 160.6 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-asparagine catabolism | aatP | med | ABC transporter for L-Asparagine and possibly other L-amino acids, putative ATPase component (characterized) | 42% | 87% | 149.8 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-aspartate catabolism | aatP | med | ABC transporter for L-Asparagine and possibly other L-amino acids, putative ATPase component (characterized) | 42% | 87% | 149.8 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| putrescine catabolism | potA | lo | spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 (characterized) | 36% | 74% | 179.1 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-arabinose catabolism | xacJ | lo | Xylose/arabinose import ATP-binding protein XacJ; EC 7.5.2.13 (characterized, see rationale) | 36% | 69% | 171.8 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-maltose catabolism | thuK | lo | Trehalose/maltose import ATP-binding protein MalK; EC 7.5.2.1 (characterized) | 31% | 83% | 169.9 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| trehalose catabolism | thuK | lo | Trehalose/maltose import ATP-binding protein MalK; EC 7.5.2.1 (characterized) | 31% | 83% | 169.9 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-cellobiose catabolism | gtsD | lo | GtsD (GLcK), component of Glucose porter, GtsABCD (characterized) | 39% | 61% | 166.4 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-glucose catabolism | gtsD | lo | GtsD (GLcK), component of Glucose porter, GtsABCD (characterized) | 39% | 61% | 166.4 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| lactose catabolism | gtsD | lo | GtsD (GLcK), component of Glucose porter, GtsABCD (characterized) | 39% | 61% | 166.4 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-maltose catabolism | gtsD | lo | GtsD (GLcK), component of Glucose porter, GtsABCD (characterized) | 39% | 61% | 166.4 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| sucrose catabolism | gtsD | lo | GtsD (GLcK), component of Glucose porter, GtsABCD (characterized) | 39% | 61% | 166.4 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| trehalose catabolism | gtsD | lo | GtsD (GLcK), component of Glucose porter, GtsABCD (characterized) | 39% | 61% | 166.4 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-maltose catabolism | musK | lo | ABC-type maltose transporter (EC 7.5.2.1) (characterized) | 34% | 75% | 164.5 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| xylitol catabolism | Dshi_0546 | lo | ABC transporter for Xylitol, ATPase component (characterized) | 38% | 67% | 161.8 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-histidine catabolism | PA5503 | lo | Methionine import ATP-binding protein MetN 2, component of L-Histidine uptake porter, MetIQN (characterized) | 40% | 69% | 161.4 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-maltose catabolism | malK1 | lo | MalK; aka Sugar ABC transporter, ATP-binding protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins (characterized) | 37% | 60% | 161.4 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-cellobiose catabolism | SMc04256 | lo | ABC transporter for D-Cellobiose and D-Salicin, ATPase component (characterized) | 37% | 63% | 161 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-galactose catabolism | PfGW456L13_1897 | lo | ABC transporter for D-Galactose and D-Glucose, ATPase component (characterized) | 38% | 61% | 161 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-maltose catabolism | malK_Aa | lo | ABC-type maltose transporter (EC 7.5.2.1) (characterized) | 34% | 65% | 157.9 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| N-acetyl-D-glucosamine catabolism | SMc02869 | lo | N-Acetyl-D-glucosamine ABC transport system, ATPase component (characterized) | 35% | 71% | 157.1 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-glucosamine (chitosamine) catabolism | SMc02869 | lo | N-Acetyl-D-glucosamine ABC transport system, ATPase component (characterized) | 35% | 71% | 157.1 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| trehalose catabolism | treV | lo | TreV, component of Trehalose porter (characterized) | 31% | 92% | 155.6 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-asparagine catabolism | peb1C | lo | PEB1C, component of Uptake system for glutamate and aspartate (characterized) | 38% | 92% | 154.8 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-aspartate catabolism | peb1C | lo | PEB1C, component of Uptake system for glutamate and aspartate (characterized) | 38% | 92% | 154.8 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-glucosamine (chitosamine) catabolism | SM_b21216 | lo | ABC transporter for D-Glucosamine, ATPase component (characterized) | 38% | 63% | 154.8 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| lactose catabolism | lacK | lo | ABC transporter for Lactose, ATPase component (characterized) | 37% | 63% | 154.5 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-mannose catabolism | TT_C0211 | lo | Sugar-binding transport ATP-binding protein aka MalK1 aka TT_C0211, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose (characterized) | 33% | 74% | 154.5 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| sucrose catabolism | thuK | lo | Sugar-binding transport ATP-binding protein aka MalK1 aka TT_C0211, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose (characterized) | 33% | 74% | 154.5 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-asparagine catabolism | bztD | lo | BztD, component of Glutamate/glutamine/aspartate/asparagine porter (characterized) | 39% | 85% | 153.3 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-aspartate catabolism | bztD | lo | BztD, component of Glutamate/glutamine/aspartate/asparagine porter (characterized) | 39% | 85% | 153.3 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-histidine catabolism | bgtA | lo | BgtA aka SLR1735, component of Arginine/lysine/histidine/glutamine porter (characterized) | 37% | 96% | 152.5 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-lysine catabolism | hisP | lo | BgtA aka SLR1735, component of Arginine/lysine/histidine/glutamine porter (characterized) | 37% | 96% | 152.5 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-histidine catabolism | aapP | lo | ABC transporter for L-Glutamine, L-Histidine, and other L-amino acids, ATPase component (characterized) | 39% | 88% | 150.6 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-histidine catabolism | hisP | lo | Histidine transport ATP-binding protein HisP (characterized) | 37% | 95% | 150.6 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-asparagine catabolism | glnQ | lo | Glutamine ABC transporter ATP-binding protein, component of Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding both substrate and the transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains (SBDs) differ in substrate specificity and affinity, allowing cells to efficiently accumulate different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate affinity (characterized) | 37% | 96% | 149.1 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-asparagine catabolism | aapP | lo | AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) (characterized) | 37% | 89% | 148.7 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-aspartate catabolism | aapP | lo | AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) (characterized) | 37% | 89% | 148.7 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-glutamate catabolism | aapP | lo | AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) (characterized) | 37% | 89% | 148.7 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-leucine catabolism | aapP | lo | AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) (characterized) | 37% | 89% | 148.7 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-proline catabolism | aapP | lo | AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux) (characterized) | 37% | 89% | 148.7 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-alanine catabolism | Pf6N2E2_5405 | lo | ABC transporter for D-Alanine, ATPase component (characterized) | 38% | 88% | 147.9 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-citrulline catabolism | AO353_03040 | lo | ABC transporter for L-Arginine and L-Citrulline, ATPase component (characterized) | 34% | 95% | 144.8 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| D-sorbitol (glucitol) catabolism | mtlK | lo | ABC transporter for D-Sorbitol, ATPase component (characterized) | 34% | 68% | 144.8 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |
| L-tryptophan catabolism | ecfA1 | lo | Energy-coupling factor transporter ATP-binding protein EcfA1; Short=ECF transporter A component EcfA; EC 7.-.-.- (characterized, see rationale) | 36% | 73% | 124.8 | ABC-type quaternary amine transporter (EC 7.6.2.9) | 46% | 356.7 |