Align Propionyl-CoA carboxylase beta chain; PCCase; Propanoyl-CoA:carbon dioxide ligase; EC 6.4.1.3 (characterized)
to candidate WP_011782756.1 MVAN_RS28370 acyl-CoA carboxylase subunit beta
Query= SwissProt::P53003 (546 letters) >NCBI__GCF_000015305.1:WP_011782756.1 Length = 516 Score = 486 bits (1252), Expect = e-142 Identities = 258/528 (48%), Positives = 343/528 (64%), Gaps = 17/528 (3%) Query: 20 TTAGKLADLYRRNHEAVHAGSERAVAKQHAKGKRTARERIDMLLDEGSFVELDEHARHRS 79 TTA LA+L + A G E+AVAK+ KG +AR RI LLD GSF+E+ A+ Sbjct: 5 TTAELLAELREKLELAKEPGGEKAVAKREKKGIPSARARIHALLDPGSFLEIGALAKTPG 64 Query: 80 TNFGMDADRPYGDGVVTGWGTVDGRRVCVFSQDFTVFGGSLGEVFGEKIVKVMDLAMKTG 139 D D YGDGVVTG GT++GR V VFS D TVF GS+GE+FG K+ ++M+ G Sbjct: 65 -----DPDALYGDGVVTGHGTINGRPVGVFSHDQTVFQGSVGEMFGRKVARLMEWVAMVG 119 Query: 140 CPLVGINDSGGARIQEGVAALGLYAEIFKRNTHASGVIPQISLIMGPCAGGAVYSPAITD 199 CP++GINDS GARIQ+ +L YAE+ +R+ G++P+ISLI G CAGGAVYSP TD Sbjct: 120 CPIIGINDSAGARIQDTATSLAWYAELGRRHELLRGLVPEISLIFGKCAGGAVYSPIQTD 179 Query: 200 FTVMVDQTSHMFITGPDVIKTVTGEDVSFEDLGGARTHNERSGNAHYLATDEDDAISYVK 259 V V +MF+TGPDVIK VTGEDV+ ++LGGA R GN H + E A YV+ Sbjct: 180 LVVAVRDQGYMFVTGPDVIKDVTGEDVTLDELGGADAQ-ARYGNIHQVVESEAAAFQYVR 238 Query: 260 ELLSFLPSNNLSSSPVF-PGAEVEEGSVADGVGDADLELDALVPDSPNQPYDMREVITRL 318 + LSFLP N +P+ PG E E V DLELDA+VPD+ NQ YDM E++ R+ Sbjct: 239 DYLSFLPGNAFDDAPIVNPGLEPE-------VTPHDLELDAIVPDADNQAYDMMEILLRI 291 Query: 319 VDEGEFLEVSALFAPNMLCGFGRIEGASVGVVANQPMQLAGTLDIDASEKAARFVRFCDA 378 D+G+ +V P ++ F R++G VG++ANQPM ++G +D +AS+KAARFVRFCD+ Sbjct: 292 FDDGDVFQVGEQAGPAIITAFARVDGRPVGIIANQPMYMSGAIDNEASDKAARFVRFCDS 351 Query: 379 FNIPVLTLVDVPGFLPGTGQEWNGIIRRGAKLLYAYAEATVPLVTVITRKAYGGAYDVMG 438 FN P++ +VD PGF+PG QE GII+RG + L A EA VP VT+ RK+YGGAY VMG Sbjct: 352 FNTPLVFVVDTPGFMPGVEQEKGGIIKRGGRFLNAVVEADVPKVTITIRKSYGGAYAVMG 411 Query: 439 SKHLGADINLAWPTAQIAVMGAQGAANILYRRQLAEAAERGEDVEALRARLQQEYEDTLC 498 SK L AD N AWPTA+IAV+GA+GAA +L +R A +V+ +RA + Y L Sbjct: 412 SKQLTADFNFAWPTARIAVIGAEGAAQLLVKRFPDPTA---PEVQKIRADFIEGYNANLA 468 Query: 499 NPYVAAERGYVDSVIPPSHTRGHVARALRMLADKREALPAKKHGNIPL 546 P++AAERG++D V+ P TR + + + +L DK+ +KHG P+ Sbjct: 469 TPWIAAERGFIDGVVEPHETRLLLRKCMHLLRDKQINRVQRKHGLTPI 516 Lambda K H 0.318 0.136 0.398 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 698 Number of extensions: 29 Number of successful extensions: 7 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 546 Length of database: 516 Length adjustment: 35 Effective length of query: 511 Effective length of database: 481 Effective search space: 245791 Effective search space used: 245791 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory