GapMind for catabolism of small carbon sources

 

Protein WP_011840150.1 in Cereibacter sphaeroides ATCC 17029

Annotation: NCBI__GCF_000015985.1:WP_011840150.1

Length: 295 amino acids

Source: GCF_000015985.1 in NCBI

Candidate for 15 steps in catabolism of small carbon sources

Pathway Step Score Similar to Id. Cov. Bits Other hit Other id. Other bits
N-acetyl-D-glucosamine catabolism nagK med N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 (characterized) 38% 96% 184.9 glucokinase (EC 2.7.1.2) 34% 152.1
D-glucosamine (chitosamine) catabolism nagK med N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 (characterized) 38% 96% 184.9 glucokinase (EC 2.7.1.2) 34% 152.1
D-cellobiose catabolism glk lo glucokinase (EC 2.7.1.2) (characterized) 34% 98% 152.1 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 38% 184.9
D-glucose catabolism glk lo glucokinase (EC 2.7.1.2) (characterized) 34% 98% 152.1 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 38% 184.9
lactose catabolism glk lo glucokinase (EC 2.7.1.2) (characterized) 34% 98% 152.1 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 38% 184.9
D-maltose catabolism glk lo glucokinase (EC 2.7.1.2) (characterized) 34% 98% 152.1 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 38% 184.9
sucrose catabolism glk lo glucokinase (EC 2.7.1.2) (characterized) 34% 98% 152.1 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 38% 184.9
trehalose catabolism glk lo glucokinase (EC 2.7.1.2) (characterized) 34% 98% 152.1 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 38% 184.9
D-mannitol catabolism mak lo Mannokinase (EC 2.7.1.7) (characterized) 32% 98% 150.2 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 38% 184.9
D-mannose catabolism mannokinase lo Mannokinase (EC 2.7.1.7) (characterized) 32% 98% 150.2 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 38% 184.9
D-fructose catabolism scrK lo Fructokinase; D-fructose kinase; Manno(fructo)kinase; EC 2.7.1.4 (characterized) 32% 98% 144.4 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 38% 184.9
D-mannitol catabolism scrK lo Fructokinase; D-fructose kinase; Manno(fructo)kinase; EC 2.7.1.4 (characterized) 32% 98% 144.4 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 38% 184.9
D-mannose catabolism scrK lo Fructokinase; D-fructose kinase; Manno(fructo)kinase; EC 2.7.1.4 (characterized) 32% 98% 144.4 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 38% 184.9
D-sorbitol (glucitol) catabolism scrK lo Fructokinase; D-fructose kinase; Manno(fructo)kinase; EC 2.7.1.4 (characterized) 32% 98% 144.4 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 38% 184.9
sucrose catabolism scrK lo Fructokinase; D-fructose kinase; Manno(fructo)kinase; EC 2.7.1.4 (characterized) 32% 98% 144.4 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 38% 184.9

Sequence Analysis Tools

View WP_011840150.1 at NCBI

Find papers: PaperBLAST

Find functional residues: SitesBLAST

Search for conserved domains

Find the best match in UniProt

Compare to protein structures

Predict transmenbrane helices: Phobius

Predict protein localization: PSORTb

Find homologs in fast.genomics

Fitness BLAST: loading...

Sequence

MLIAFDIGGSRIRAARAFAPDDLEPLGERPMPLSFPGFVAALRDLMPEEATSLAIAIAGV
VDPDTGRITAANLPAVNQRALAADLCAALGRPVWIGNDADCFVLTEALLGVGRGHRSVFG
IILGSGVGGGIVLDGRLLTGAGGIAGEWGHAPVLDQRPLGRDLPHLPCGCGQSGCVDTYG
SARGIERLHLALCGQRLDSREILAAWRAGEMAAAETVEVWLELVAGPLAMLVNVIGPSVV
PVGGGLSNDGDLVAALDRAVRHRLLRPASETLLRPAFHPEPGLVGAALAGLQALG

This GapMind analysis is from Apr 10 2024. The underlying query database was built on Sep 17 2021.

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About GapMind

Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.

A candidate for a step is "high confidence" if either:

where "other" refers to the best ublast hit to a sequence that is not annotated as performing this step (and is not "ignored").

Otherwise, a candidate is "medium confidence" if either:

Other blast hits with at least 50% coverage are "low confidence."

Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:

GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).

For more information, see:

If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know

by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory