Align Indolepyruvate oxidoreductase subunit IorA; IOR; Indolepyruvate ferredoxin oxidoreductase subunit alpha; EC 1.2.7.8 (characterized)
to candidate WP_013258571.1 DEBA_RS08765 indolepyruvate ferredoxin oxidoreductase subunit alpha
Query= SwissProt::P80910 (618 letters) >NCBI__GCF_000143965.1:WP_013258571.1 Length = 632 Score = 531 bits (1368), Expect = e-155 Identities = 290/638 (45%), Positives = 400/638 (62%), Gaps = 36/638 (5%) Query: 3 LDDILDAGRGDRLFLLGNEAAVRAAIESGVGVASTYPGTPSSEIGNVLSKIAKRAG---- 58 +DD+L G + LLGNEA VR A+E+G+ A+ YPGTPSSE+ + L ++ +++ Sbjct: 1 MDDLLSPKGGAQKLLLGNEAIVRGALEAGLAFATCYPGTPSSEVPDTLHRLMRQSPEQVK 60 Query: 59 IYFEFSINEKVALEVAAAAAASGVRSFTFMKHVGLNVASDSFMSVAYTGVRAGMVVLSAD 118 +FE+S NEKVALE A+ AAA+G+R+ MKHVGLNVA+D M++AY+GVRAGMV+L+AD Sbjct: 61 YHFEYSTNEKVALETASGAAAAGLRTLCTMKHVGLNVAADPLMTLAYSGVRAGMVILTAD 120 Query: 119 DPSMFSSQNEQDNRHYARLAWVPLLEPSNPQEILEYMNHAFELSEEYRIPVLLRTTTRVS 178 DPS+FSSQNEQDNR+YAR + +P+LEP++P + +A ELSE+ PVLLRTTTRV+ Sbjct: 121 DPSLFSSQNEQDNRYYARQSGLPMLEPADPAQAKAMTKYAMELSEQLETPVLLRTTTRVN 180 Query: 179 HMRGVVEAGERRAEPVKGFFRKNPEQFVPVPATARVMRRELVEKMKKLKRVADTSELNRV 238 H RG V + K F K P +FV VPA +R + L+ +K + +++ S N V Sbjct: 181 HTRGAVGLDDLPEVKTKAHFVKEPTRFVGVPAVSRNLHLRLLRIYEKAQALSEASPFNSV 240 Query: 239 LNEDSESDLGIIASGGAFNYVYDALQTLGL--DVPVLKLGFTYPFPAGLVAEFLSGLEGV 296 + LG++A G YV DA++ L + + LGF++P P +A FL ++ V Sbjct: 241 ---KGKGRLGVVACGVCVAYVADAVKDLDAAGQIKIFNLGFSWPLPEKKLARFLKSVDQV 297 Query: 297 LVVEEVDSVMEKEVLAVATSEGLDVGVHGKLDGTLPEI-------------YEYSEDIVR 343 LVVEE++ ++E + A+A +G+ V + GK G +P + YEY+ +VR Sbjct: 298 LVVEELEPLVENALRAIAQEKGIAVKISGKTPGAIPAVSVDVRAPEVFTRAYEYNPRLVR 357 Query: 344 RAISGLTGIKSHEKGI----EAPELPERPPALCPGCPHRAMYYSVRRAASELGIEGEDLI 399 + I+ +K + + + P LP RPP LC GCPHRA Y++V++A G + + Sbjct: 358 QTIAKAFKLKDNSPPVLDLSDRPALPGRPPNLCAGCPHRATYFAVKQAV------GPEAV 411 Query: 400 FPTDIGCYTLGIEPPYSAADYLLSMGSSVGTACGFSAATSQRIVSFIGDSTFFHAGIPPL 459 F TDIGCYTLG+ PP S ADYL+ MGSSV +A G + AT Q++V+FIGDSTFFH+GI L Sbjct: 412 FTTDIGCYTLGMLPPISMADYLICMGSSVSSAGGIARATDQKVVAFIGDSTFFHSGITGL 471 Query: 460 INAVHNRQRFVLVILDNRTTAMTGGQPHPGLPVDGMGEEAPAISIEDITRACGVEFVETV 519 +NAVHNR F LVILDN TTAMTG QPHPG+ G+ ++ + IE + R GVE V TV Sbjct: 472 VNAVHNRHNFTLVILDNGTTAMTGHQPHPGVS-QGLADDKTHVDIEKLVRGLGVEHVTTV 530 Query: 520 NPMNIRRSSETIRRALQHESVAVVISRYPCML--SEGAVRGR-PVRVDEEKCDLCLECLN 576 P + S + I+ A + V+VVISR C L A RGR P RVD KC +C+N Sbjct: 531 KPFKVAASVKAIKEAADYPGVSVVISREICPLYGRRVAPRGRKPFRVDPGKCKNHRDCIN 590 Query: 577 ELACPAIVEEDGRVFIDPLYCRGCTICLQICPAGAIKP 614 +ACPA + I+ C GC +C QICP AI P Sbjct: 591 TVACPAFYIAGDQPAINASQCIGCALCAQICPENAITP 628 Lambda K H 0.319 0.137 0.398 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 893 Number of extensions: 35 Number of successful extensions: 8 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 618 Length of database: 632 Length adjustment: 37 Effective length of query: 581 Effective length of database: 595 Effective search space: 345695 Effective search space used: 345695 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 54 (25.4 bits)
This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory