Align phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) (characterized)
to candidate WP_041099655.1 SUTH_RS12465 alpha-D-glucose phosphate-specific phosphoglucomutase
Query= BRENDA::Q9SCY0 (623 letters) >NCBI__GCF_000828635.1:WP_041099655.1 Length = 547 Score = 620 bits (1600), Expect = 0.0 Identities = 322/561 (57%), Positives = 407/561 (72%), Gaps = 18/561 (3%) Query: 67 IEIKSLPTKPIEGQKTGTSGLRKKVKVFMEDNYLANWIQALFNSLPLEDYKNATLVLGGD 126 + I ++ T P QK GTSGLRKKV VF YL N++QA+F+++ +TLVLGGD Sbjct: 1 MNIATVITTPFSDQKPGTSGLRKKVTVFRTPGYLENFVQAVFDTIDAPP--GSTLVLGGD 58 Query: 127 GRYFNKEASQIIIKIAAGNGVGQILVGKEGILSTPAVSAVIRKRKANGGFIMSASHNPGG 186 GRY N+EA Q+I+++AA G+ ++LVG+ GILSTPA S VIRK GG I+SASHNPGG Sbjct: 59 GRYHNREAIQVILRMAAAAGIAKVLVGRGGILSTPAASRVIRKYGCFGGLILSASHNPGG 118 Query: 187 PEYDWGIKFNYSSGQPAPETITDKIYGNTLSISEIKVAEIPDIDLSQVGVTKYGNFSVEV 246 PE D+GIK+N +G PAPE ITD I+ + ++ ++A+ PD+DL + G G+ VE+ Sbjct: 119 PEGDFGIKYNTGNGGPAPEKITDAIFARSRELTRYRIADAPDLDLDRPGRHGLGDMVVEI 178 Query: 247 IDPVSDYLELMEDVFDFDLIRGLLSRSDFGFMFDAMHAVTGAYAKPIFVDNLGAKPDSIS 306 IDPV+DY ELME +FDF IR L+ S F FDAMHAVTG YA+ I LGA ++ Sbjct: 179 IDPVADYAELMESLFDFAAIRTLIG-SGFRLCFDAMHAVTGPYAREIIEARLGAPAGTVI 237 Query: 307 NGVPLEDFGHGHPDPNLTYAKDLVDVMY----RDNGPDFGAASDGDGDRNMVLGNKFFVT 362 NGVPLEDFG GHPDPNLTYA LV +MY + PDFGAASDGDGDRNM+LG FFVT Sbjct: 238 NGVPLEDFGGGHPDPNLTYADQLVAIMYGGDDANPAPDFGAASDGDGDRNMILGRHFFVT 297 Query: 363 PSDSVAIIAANAQEAIPYFRAGPKGLARSMPTSGALDRVAEKLKLPFFEVPTGWKFFGNL 422 PSDS+AIIAANA A P + G G+ARSMPTS A DRVAEKL +P +E PTGWKFFGNL Sbjct: 298 PSDSLAIIAANAALA-PGYADGIAGIARSMPTSAAADRVAEKLGVPCYETPTGWKFFGNL 356 Query: 423 MDAGKLSICGEESFGTGSDHIREKDGIWAVLAWLSILAHRNKDTKPGDKLVSVADVVKEY 482 MDAGK+++CGEESFGTGS H+REKDG+WAVL WL+ILA+ +SVA++V + Sbjct: 357 MDAGKVTLCGEESFGTGSSHVREKDGLWAVLFWLNILANSR---------LSVAEIVHRH 407 Query: 483 WATYGRNFFSRYDYEECESEGANKMIEYLREILSKSKAGDVYGNYVLQFADDFSYTDPVD 542 WA YGRN +SR+DYE S+ A ++ +R + G +G+Y ++F DDFSYTDP+D Sbjct: 408 WAGYGRNVYSRHDYEALPSDVAAGVMAQVRGRFA-DLPGQRFGDYRVKFCDDFSYTDPID 466 Query: 543 GSVASKQGVRFVFTDGSRIIFRLSGTGSAGATVRIYIEQFEPDVSKHDVDAQIALKPLID 602 GS+++ QG+R F DGSRI+FRLSGTG+ GAT+RIY+E FEPD ++ VDAQ AL PLI Sbjct: 467 GSLSTGQGLRIGFEDGSRIVFRLSGTGTEGATLRIYLEAFEPDPARQRVDAQQALAPLIA 526 Query: 603 LALSVSKLKDFTGREKPTVIT 623 +A +S+LK TGRE+PTVIT Sbjct: 527 IADQLSELKQRTGRERPTVIT 547 Lambda K H 0.317 0.136 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 1079 Number of extensions: 59 Number of successful extensions: 7 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 623 Length of database: 547 Length adjustment: 36 Effective length of query: 587 Effective length of database: 511 Effective search space: 299957 Effective search space used: 299957 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 53 (25.0 bits)
This GapMind analysis is from Apr 09 2024. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory