Align Acyl-CoA synthetase short-chain family member 3, mitochondrial; Acetate--CoA ligase 3; Acyl-CoA synthetase short-chain family member 3; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 (characterized)
to candidate WP_068168785.1 HTA01S_RS07630 propionate--CoA ligase
Query= SwissProt::Q9H6R3 (686 letters) >NCBI__GCF_001592305.1:WP_068168785.1 Length = 633 Score = 516 bits (1329), Expect = e-150 Identities = 272/635 (42%), Positives = 400/635 (62%), Gaps = 22/635 (3%) Query: 62 YKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPSTRWFVEGMLNICYNAVDRHI 121 Y S+ + + FW + A+ + W+KP+ + + P RWF G+ N+C+NAVDRH+ Sbjct: 7 YTEFHRRSIEERDAFWAEQAQLVDWHKPFDRVCNYDNPPFARWFEGGLTNLCHNAVDRHL 66 Query: 122 ENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQA 181 ++ + D+ A+I+ S T+T+ T+ ++E+ +V ++A +L G+KKGD V+IYMPMIPQA Sbjct: 67 KD-RADQNALIFVSTETDTEKTYNFRELHAEVQRMAAILQAQGVKKGDRVLIYMPMIPQA 125 Query: 182 MYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEA 241 + MLACAR+GAIHS++FGGFAS L+SRI+ P V+V+A G G+ VEY PL++EA Sbjct: 126 AFAMLACARVGAIHSVVFGGFASHSLASRIEDASPVVIVSADAGSRGGKVVEYKPLLDEA 185 Query: 242 LKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSH--DCVPVLSEHPLYILYT 299 +++ HKP K+++ +R + A GRD+D+ E AK C V + HP Y LYT Sbjct: 186 IRLSAHKPQKVVMVDR-GLAAFDAVEGRDVDYAAERAKHMDTVVPCEWVDATHPSYTLYT 244 Query: 300 SGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHG 359 SGTTG PKGV R TGGYAV L SM IY +PGE +++ SD+GWVVGHSYI YGPL+ G Sbjct: 245 SGTTGKPKGVQRDTGGYAVALAASMKHIYMGEPGETYFSTSDIGWVVGHSYIIYGPLIGG 304 Query: 360 NTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFK 419 T++YEG P+ PDAG ++ ++ ++ V+ +F+APTA+R +++ D ++ K+Y ++ K Sbjct: 305 MATIMYEGLPI-RPDAGIWWSLVEKYKVSVMFSAPTAVRVLKKYD--SSFIKKYDISSLK 361 Query: 420 TLFVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPP---GQAG 476 LF+AGE D T +W P++D++WQTETG PI A C N P P G G Sbjct: 362 ALFLAGEPLDEPTAQWISGELGKPIVDNYWQTETGWPILAIC----NGVEPAPSKFGSPG 417 Query: 477 KSVPGYNVMILDDNM-QKLK-ARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPG- 533 K+V GY+V +LDD ++LK + G + V+ PLPPG +W + E F Y+ PG Sbjct: 418 KAVYGYDVKLLDDQSGEELKGSNQKGVVAVEGPLPPGCMQTIWGDDERFVKTYWSSVPGK 477 Query: 534 -YYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDP 592 Y T D G D +GY +++ R DDVINVAGHR+ IEESI SH +A+ AVVG D Sbjct: 478 MVYSTFDWGIRDADGYYFILGRTDDVINVAGHRLGTREIEESISSHPRIAEVAVVGVADQ 537 Query: 593 LKGHVPLALCVLRKDINATEE----QVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSG 648 LKG V +A V++ T++ ++ E++K V + +G VA FV LPKTRSG Sbjct: 538 LKGQVAMAFAVVKDASLLTDDAARLKLEGEVMKLVDEQLGAVARPARVRFVSILPKTRSG 597 Query: 649 KIPRSALSAIVNGKPYKITSTIEDPSIFGHVEEML 683 K+ R A+ A+ G+ +T++DP+ ++++L Sbjct: 598 KLLRRAIQAVCEGRDPGDLTTMDDPAALQQIKDLL 632 Lambda K H 0.318 0.136 0.422 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 1121 Number of extensions: 64 Number of successful extensions: 9 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 686 Length of database: 633 Length adjustment: 38 Effective length of query: 648 Effective length of database: 595 Effective search space: 385560 Effective search space used: 385560 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 54 (25.4 bits)
This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory