Align Putative aldehyde dehydrogenase AldA; EC 1.2.1.3 (uncharacterized)
to candidate WP_092346115.1 BLU87_RS07020 aldehyde dehydrogenase
Query= curated2:Q2YV11 (495 letters) >NCBI__GCF_900107645.1:WP_092346115.1 Length = 491 Score = 548 bits (1411), Expect = e-160 Identities = 267/491 (54%), Positives = 359/491 (73%) Query: 5 VRDYIAENYGLFINGEFVKGSSDETIEVTNPATGETLSHITRAKDKDVDHAVEVAQEAFE 64 +R+ I + Y L+I+G++V S +T E PA G+ L+ A +DVD AV+ A +AF Sbjct: 1 MRNQIDKQYKLYIDGKWVDASDGKTFEAHCPADGKLLATCANATKQDVDDAVKAAWKAFP 60 Query: 65 SWSLTSKSERAQMLRDIGDKLMAQKDKIAMIETLNNGKPIRETTAIDIPFAARHFHYFAS 124 W S +R+ +L I D + +K+AMIE+++NGKP+RETTA+D+P A+ HF YFA Sbjct: 61 EWKDISPQDRSIILLKIADLIDENAEKLAMIESIDNGKPLRETTAVDVPLASDHFRYFAG 120 Query: 125 VIETEEGTVNDIDKDTMSIVRHEPIGVVGAVVAWNFPMLLAAWKIAPAIAAGNTIVIQPS 184 VI +EG IDK+TMSI+ EPIGV+G ++ WNFP+L+AAWKIAPA+AAGN +V++PS Sbjct: 121 VIRAQEGQAVMIDKNTMSIILREPIGVIGQIIPWNFPLLMAAWKIAPALAAGNCVVLKPS 180 Query: 185 SSTPLSLLEVAKIFQEVLPKGVVNILTGKGSESGNAIFNHDGVDKLSFTGSTDVGYQVAE 244 S+T LSLLE AK+ VLP GVVN++TGKGS +GN + H+G KL+FTGST+VGY +A+ Sbjct: 181 STTSLSLLEFAKLLDTVLPPGVVNVVTGKGSSTGNFVLEHEGFSKLAFTGSTEVGYNIAD 240 Query: 245 AAAKHLVPATLELGGKSANIILDDANLDLAVEGIQLGILFNQGEVCSAGSRLLVHEKIYD 304 AAAK L+PATLELGGKSANI +D + A+EG QLGIL NQG+VC AGSR+ V E IYD Sbjct: 241 AAAKKLIPATLELGGKSANIYFEDCPWEKAIEGTQLGILLNQGQVCCAGSRVFVQESIYD 300 Query: 305 QLVPRLQEAFSNIKVGDPQDEATQMGSQTGKDQLDKIQSYIDVAKESDAQILAGGHRLTE 364 + V + EAF +KV P + T MG+Q + QL+KI +Y++V K+ A+++ GG R+T Sbjct: 301 KFVEAMAEAFKKVKVNLPWADGTMMGAQIDEVQLNKILAYVEVGKQEGARLVTGGKRITT 360 Query: 365 NGLDKGFFFEPTLIAVPDNHHKLAQEEIFGPVLTVIKVKDDQEAIDIANDSKYGLAGGVF 424 L KG+F EPTL A +N ++AQEEIFGPV+ VIK KD++E I++ANDS YGLAG V+ Sbjct: 361 GELGKGYFMEPTLFADVNNDMRIAQEEIFGPVVCVIKFKDEEEVINMANDSDYGLAGAVW 420 Query: 425 SQNITRALNIAKAVRTGRIWINTYNQVPEGAPFGGYKKSGIGRETYKGALSNYQQVKNIY 484 +++I RAL +A+AV+TGR+W+NTYNQ+P PFGGYKKSGIGRET+K L +Y Q KNIY Sbjct: 421 TKDINRALRVARAVQTGRMWVNTYNQLPAHTPFGGYKKSGIGRETHKMMLEHYTQTKNIY 480 Query: 485 IDTSNALKGLY 495 I + GLY Sbjct: 481 ISMTEDKIGLY 491 Lambda K H 0.315 0.133 0.377 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 635 Number of extensions: 22 Number of successful extensions: 1 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 495 Length of database: 491 Length adjustment: 34 Effective length of query: 461 Effective length of database: 457 Effective search space: 210677 Effective search space used: 210677 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory