Align indolepyruvate ferredoxin oxidoreductase (subunit 2/2) (EC 1.2.7.8) (characterized)
to candidate WP_092347349.1 BLU87_RS09500 indolepyruvate oxidoreductase
Query= BRENDA::O07835 (647 letters) >NCBI__GCF_900107645.1:WP_092347349.1 Length = 608 Score = 372 bits (955), Expect = e-107 Identities = 244/631 (38%), Positives = 351/631 (55%), Gaps = 45/631 (7%) Query: 18 LLLGNHAIARGALEANIAVFAAYPGTPSSELTDTMAAVAKKA--GVYMEYSTNEKVAFET 75 LL+GN AI +G +EA V AAYPGTPS+E+ + ++A +++E+S NEK+AFE Sbjct: 7 LLMGNEAIGQGLIEAGCQVAAAYPGTPSTEILQAVIDRQEQAVEPLHIEWSVNEKIAFEV 66 Query: 76 ALAAAWSGLRAMTAMKHVGLNVAADSFLSSVGMGVEGGFVIMVADDPSMWSSQNEQDTRV 135 ALAA+++G R++ MK VGLNVAAD F+ + +G++GG + +VADDP SSQNEQDTR+ Sbjct: 67 ALAASYTGKRSVAVMKQVGLNVAADPFMRTAYIGIKGGMLTIVADDPGPHSSQNEQDTRL 126 Query: 136 YAKFANVPVLEPSSPHEAKEMTKYAFELSEKFKHFVILRTTTRSSHARGDVVLGELPEEI 195 + A VPVL+PSSP EAK M + AFELSEK++ ++LR TTR H+R +V L E P E+ Sbjct: 127 FCLQARVPVLDPSSPAEAKAMIQPAFELSEKYETNIVLRPTTRICHSRQNVSL-EKPIEL 185 Query: 196 KTGKRKFGKFKKDPTRFVDVPAHARKFHPLILEKIEKIREELNNCPFNWIEGKEDAKVGI 255 K + F+ +PTR+ PA + H + +E+I E P + + Sbjct: 186 K----RQADFEPNPTRWAATPAFLPQLHRNLNRHLEEIALEPAWQPRLLSGNESQPRTAF 241 Query: 256 IAPGLSYAYVKEALAWLGVE-DVKILKLGTPFPVPYGLLGKFFDGLEKVLIVEELEPVVE 314 IA G++Y+ + + L LG++ + + ++ P+P+ ++VLI+EE PV+E Sbjct: 242 IASGIAYSNLVDLLEELGLDHTIDLYQVLMPYPLNPDFCKLMQKKYDRVLILEETYPVIE 301 Query: 315 EQVKTWAYDKGLRIPIHGKDLVPRVYEMTTRRAVEAIAKFLGLETPINFAEIDEKYEKVS 374 Q+ A+ + G VPR E+T +A+A FL L P EK + Sbjct: 302 LQL---AHPGAVGKQTGG---VPREGELTPDVIHQALADFLQLAPPA---------EKPA 346 Query: 375 QIVPPRPPSLCPACPHRNSFFAIRKAAGPKAIYPSDIGCYTLGVLPPLRTVDTTVAMGAS 434 R PSLCP C HR +F+ I+K PK I+PSDIGCYTLG+ L V T MGA Sbjct: 347 ARRGQR-PSLCPGCSHRTAFYTIKKCF-PKGIFPSDIGCYTLGM--NLGAVHTVHCMGAC 402 Query: 435 IGIGHGLSIAMNGSLAEEEHKEGKEKQIIVATIGDSTFYHTGLPALANAIYNRSNVLIVV 494 I G G A ++ + IV TIGDSTF+H G+PAL NA+ ++ +++V+ Sbjct: 403 ISQGAGFYQAY--------QQDDGQFPTIVVTIGDSTFFHAGIPALINAVIQQTRMIVVI 454 Query: 495 LDNLVTAMTGDQPNPGTG-QTPHGMGKRIPIEDVAKAMGADFVAVVDPYDIKATYETIKK 553 LDN AMTG QP P G + K I IE + KA G +F+ +PYD + +K+ Sbjct: 455 LDNATAAMTGGQPVPHMGVAAGNKPTKAIAIEPLVKASGVEFLETCNPYDHERFEALLKQ 514 Query: 554 A-----LEVEGVSVVVSRQVCALYKIGQMRRRGMKWPIYHVVEDKCTGCKICINAYGCPA 608 A GV+V+++R C + R+ K ++D C GC+ C +A+ CPA Sbjct: 515 ADSYIRSPEGGVAVLIARHGCIM---DPATRKAQK-SFTVTIQDNCIGCEKCTSAFECPA 570 Query: 609 IYWDPETKKAKVDPTMCWGCGGCAQVCPFDA 639 + D A VD C GCG C VCP A Sbjct: 571 LSMDRTRNIAVVDQDRCIGCGTCIPVCPVAA 601 Lambda K H 0.319 0.136 0.412 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 935 Number of extensions: 51 Number of successful extensions: 9 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 647 Length of database: 608 Length adjustment: 38 Effective length of query: 609 Effective length of database: 570 Effective search space: 347130 Effective search space used: 347130 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 54 (25.4 bits)
This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory