Align rhamnulose-1-phosphate aldolase (EC 4.1.2.19) / lactaldehyde dehydrogenase (EC 1.2.1.22) (characterized)
to candidate YP_004144317.1 Mesci_5168 class II aldolase/adducin family protein
Query= reanno::Dino:3609047 (700 letters) >NCBI__GCF_000185905.1:YP_004144317.1 Length = 684 Score = 341 bits (874), Expect = 8e-98 Identities = 236/709 (33%), Positives = 370/709 (52%), Gaps = 43/709 (6%) Query: 10 LESRWDDEVA---------KGMSES-ELLLYRSNILGADKRVTNYGGGNTSAKVMEADPL 59 +++ W+DE A KG+ L +Y + +LG + R+ +GGGNTS K D L Sbjct: 1 MKNLWNDEAAEKLVADYAKKGVGRDLALRVYTTRLLGGEPRLVLHGGGNTSCKTTATD-L 59 Query: 60 TGAQVEVLWVKGSGGDIGSIKMDGFATLYMDKLRALKGLYRGVAFEDEMVSYLPHCTFRL 119 G Q +VL VKGSG D+G I+ G + + L + L R +A ED + + Sbjct: 60 VGDQWDVLCVKGSGWDMGVIEPQGLPAVKLKPLLKARALNR-LADEDMVALQRVNLIDPS 118 Query: 120 NPRAASIDTPLHAYVPRKHVDHVHADAIIAIAASDNSKELTQEIFGNRIGWLPWKRPGFE 179 +P S++T LHA++P K VDH H+ AI+AI ++SK L + +FG+++G++P+ PGF+ Sbjct: 119 SPNP-SVETLLHAFLPHKFVDHTHSTAILAIVDQEDSKPLVKTVFGSKMGYVPYIMPGFD 177 Query: 180 LGLWLEKFCRENPEADGVVLESHGLFTWADTAKECYDQTIDVINVATRWLAERSAGVPAF 239 L +P+ +G++L+ HG+FT+ D AK+ YD+ I +NVA ++A ++G P Sbjct: 178 LAKAAADIFDADPDVEGLILDKHGIFTFGDDAKQAYDRMIHYVNVAEDYIA--ASGKPK- 234 Query: 240 GGAIHESLPAAARREVAARLMPAIRGFVSDNQ------HMVGHFNDSDAVLEFVNARDME 293 A +LP A+ A + P +RG V+ + MV F S +++F+N+ ++ Sbjct: 235 --AAKAALP--AKLATPASIAPMLRGAVAVARGEGRFDRMVSDFRTSPVIVDFINSAEIA 290 Query: 294 ALAALGTSCPDHFLRTKIRPLVVPFDPAQNNILAVLSELPDQVAAYREAYAAYYAR--CK 351 A G S PD +R K P+ +P P + + + V A+ + Y AY+ Sbjct: 291 DYAGRGVSTPDLSIRIKTGPMALP-APDADKAGDYKAVIKSHVDAFAKDYRAYFETNDAL 349 Query: 352 HDDSPALRDPNAVVYLVPGVGMITFAKDKATARISGEFYVNAINVMRGASAVSTYQGLPE 411 D + D + LVPG+GM + A+I+ + I +RGA AV + L + Sbjct: 350 DDVKRTMLDQMPRLTLVPGLGMFGHGRTLKDAKIASDVGEMWIEAVRGAEAVGRFHPLSK 409 Query: 412 QEAFDIEYWLLEEAKLQRMPKPKSLAGRVALVTGGAGGIGAATAERFLAEGACVVLADIN 471 + F +EYW LE+AKL KPK L G+V L+TGGAG IGAATA+ F GA V+ D++ Sbjct: 410 ADLFPLEYWSLEQAKL-ASNKPKPLTGQVVLITGGAGAIGAATAKLFADNGAHAVVVDLD 468 Query: 472 EDSLASTQERLSERFGADVVRSVVMNVTREEAVAAAFAEASVEFGGVDILVSNAGIASSA 531 + A +++ G + + V ++T V AAF +A FGGVDILVSNAG A Sbjct: 469 AEKAADA----AKKAGNNSI-GVAADITDPAQVRAAFDKAVAVFGGVDILVSNAGAAWEG 523 Query: 532 PIEETSLALWNKNMDILSTGYFLVSRAAFKLMRVQDMGGAVVFVASKNGLAASPNAAAYC 591 I E AL K+ ++ + V++ A ++M Q GG ++F SK + P AY Sbjct: 524 RIGELDDALLRKSFELNFFAHQSVAQNAVRIMLEQGTGGVLLFNTSKQAVNPGPKFGAYG 583 Query: 592 TAKASEIHLARCLALEGAEAGIRVNVVNPDAVLRGSKIWEGDWLEQRAGTYGTDKDGLEE 651 KA+ + L+R AL+ GIR N VN D + G + + R+G G E+ Sbjct: 584 VPKAATLFLSRQYALDYGAHGIRSNAVNADRIRSG--LLTDAMIASRSGARGVS----EK 637 Query: 652 MYRQRSLLKRSVLPEDIAEACYFFAADASSKSTGNIINVDAGNVQAFTR 700 Y +LL + V +D+A+A F + ++T ++ VD GN+ A R Sbjct: 638 DYMSGNLLGQEVTAQDVAQA--FLHHALADRTTADVTTVDGGNIAAALR 684 Lambda K H 0.318 0.133 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 902 Number of extensions: 40 Number of successful extensions: 6 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 700 Length of database: 684 Length adjustment: 39 Effective length of query: 661 Effective length of database: 645 Effective search space: 426345 Effective search space used: 426345 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 54 (25.4 bits)
This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory