L-histidine catabolism in Rhizobium leguminosarum 3841

Best path

braC, braD, braE, braF, braG, hutH, hutU, hutI, hutF, hutG'

Rules

Overview: Histidine utilization in GapMind is based on MetaCyc pathways L-histidine degradation I (link) or II (link). These pathways are very similar. Other pathways in MetaCyc (III-VI) are not complete or are not reported in prokaryotes, so they are not included.

• all:
  • histidine-transport, hutH, hutU, hutI and hutG
  • or histidine-transport, hutH, hutU, hutI, hutH, hutF and hutG'
  • Comment: In pathway I, hutH deaminates histidine to urocanate, hutU hydrates it to 4-imidazolone-5-propanoate, hutI hydrolyzes it to N-formiminoglutamate, and hutG hydrolyzes it to formamide and glutamate. Formamide can be cleaved to formate and ammonia, but it could also be secreted, so this is not described. Similarly, formate may be oxidized to CO2 or secreted. Pathway II also involves conversion to N-formiminoglutamate, but then it is deaminated to N-formylglutamate by hutF, and hydrolyzed to formate and glutamate by hutG'.
• histidine-transport:
  • hisP, hisM, hisQ and hisJ
  • or PA5503, PA5504 and PA5505
  • or Ac3H11_2562, Ac3H11_2561, Ac3H11_2560, Ac3H11_2555 and Ac3H11_2554
  • or natA, natB, natC, natD and natE
  • or aapJ, aapQ, aapM and aapP
  • or braC, braD, braE, braF and braG
  • or hutV, hutW and hutX
  • or bgtA and bgtB
  • or BPHYT_RS24000, BPHYT_RS24005, BPHYT_RS24010 and BPHYT_RS24015
  • or permease
  • or Ga0059261_1577
  • or S15A3
  • or LAT2
  • or LHT
  • or SLC38A3
  • or PTR2
  • Comment: Transporters were identified using query: transporter:histidine:L-histidine:his

48 steps (37 with candidates)

Or see definitions of steps

Step	Description	Best candidate	2nd candidate
braC	ABC transporter for glutamate, histidine, arginine, and other amino acids, substrate-binding component BraC	RL_RS19315	RL_RS18225
braD	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 1 (BraD)	RL_RS19340	RL_RS14695
braE	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 2 (BraE)	RL_RS19335	RL_RS14690
braF	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 1 (BraF)	RL_RS19330	RL_RS34950
braG	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 2 (BraG)	RL_RS19325	RL_RS27140
hutH	histidine ammonia-lyase	RL_RS30805	RL_RS23040
hutU	urocanase	RL_RS30795	RL_RS01900
hutI	imidazole-5-propionate hydrolase	RL_RS30810
hutF	N-formiminoglutamate deiminase	RL_RS30815
hutG'	N-formylglutamate amidohydrolase	RL_RS30800	RL_RS21115
Alternative steps:
aapJ	L-histidine ABC transporter, substrate-binding component AapJ	RL_RS11425
aapM	L-histidine ABC transporter, permease component 2 (AapM)	RL_RS11415	RL_RS29540
aapP	L-histidine ABC transporter, ATPase component AapP	RL_RS11410	RL_RS30155
aapQ	L-histidine ABC transporter, permease component 1 (AapQ)	RL_RS11420	RL_RS27775
Ac3H11_2554	ABC transporter for L-Histidine, permease component 2	RL_RS23870	RL_RS27775
Ac3H11_2555	L-histidine ABC transporter, substrate-binding component 2	RL_RS23865	RL_RS14210
Ac3H11_2560	L-histidine ABC transporter, ATPase component	RL_RS32845	RL_RS28590
Ac3H11_2561	L-histidine ABC transporter, permease component 1	RL_RS29400
Ac3H11_2562	L-histidine ABC transporter, substrate-binding component 1
bgtA	L-histidine ABC transporter, ATPase component BgtA	RL_RS25475	RL_RS33345
bgtB	L-histidine ABC transporter, fused substrate-binding and permease components (BgtB/BgtAB)
BPHYT_RS24000	L-histidine ABC transporter, substrate-binding component	RL_RS30835	RL_RS14210
BPHYT_RS24005	L-histidine ABC transporter, permease component 1	RL_RS30840	RL_RS29460
BPHYT_RS24010	L-histidine ABC transporter, permease component 2	RL_RS30845	RL_RS29465
BPHYT_RS24015	L-histidine ABC transporter, ATPase component	RL_RS30850	RL_RS29450
Ga0059261_1577	L-histidine transporter
hisJ	L-histidine ABC transporter, substrate-binding component HisJ	RL_RS14210	RL_RS29455
hisM	L-histidine ABC transporter, permease component 1 (HisM)	RL_RS14220	RL_RS29465
hisP	L-histidine ABC transporter, ATPase component HisP	RL_RS29450	RL_RS30850
hisQ	L-histidine ABC transporter, permease component 2 (HisQ)	RL_RS30840	RL_RS29460
hutG	N-formiminoglutamate formiminohydrolase
hutV	L-histidine ABC transporter, ATPase component HutV	RL_RS35470	RL_RS27810
hutW	L-histidine ABC transporter, permease component HutW	RL_RS35475	RL_RS27815
hutX	L-histidine ABC transporter, substrate-binding component HutX	RL_RS35480
LAT2	L-histidine transporter
LHT	L-histidine transporter
natA	L-histidine ABC transporter, ATPase component 1 (NatA)	RL_RS14685	RL_RS34950
natB	L-histidine ABC transporter, substrate-binding component NatB
natC	L-histidine ABC transporter, permease component 1 (NatC)	RL_RS14690
natD	L-histidine ABC transporter, permease component 2 (NatD)	RL_RS34940	RL_RS19290
natE	L-histidine ABC transporter, ATPase component 2 (NatE)	RL_RS14680	RL_RS19325
PA5503	L-histidine ABC transporter, ATPase component	RL_RS27345	RL_RS33170
PA5504	L-histidine ABC transporter, permease component	RL_RS27340	RL_RS02670
PA5505	L-histidine ABC transporter, substrate-binding component	RL_RS27350
permease	L-histidine permease
PTR2	L-histidine:H+ symporter
S15A3	L-histidine transporter
SLC38A3	L-histidine:Na+ symporter

Confidence: high confidence medium confidence low confidence
transporter – transporters and PTS systems are shaded because predicting their specificity is particularly challenging.

This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.