L-histidine catabolism in Cereibacter sphaeroides ATCC 17029

Best path

aapJ, aapQ, aapM, aapP, hutH, hutU, hutI, hutF, hutG'

Rules

Overview: Histidine utilization in GapMind is based on MetaCyc pathways L-histidine degradation I (link) or II (link). These pathways are very similar. Other pathways in MetaCyc (III-VI) are not complete or are not reported in prokaryotes, so they are not included.

• all:
  • histidine-transport, hutH, hutU, hutI and hutG
  • or histidine-transport, hutH, hutU, hutI, hutH, hutF and hutG'
  • Comment: In pathway I, hutH deaminates histidine to urocanate, hutU hydrates it to 4-imidazolone-5-propanoate, hutI hydrolyzes it to N-formiminoglutamate, and hutG hydrolyzes it to formamide and glutamate. Formamide can be cleaved to formate and ammonia, but it could also be secreted, so this is not described. Similarly, formate may be oxidized to CO2 or secreted. Pathway II also involves conversion to N-formiminoglutamate, but then it is deaminated to N-formylglutamate by hutF, and hydrolyzed to formate and glutamate by hutG'.
• histidine-transport:
  • hisP, hisM, hisQ and hisJ
  • or PA5503, PA5504 and PA5505
  • or Ac3H11_2562, Ac3H11_2561, Ac3H11_2560, Ac3H11_2555 and Ac3H11_2554
  • or natA, natB, natC, natD and natE
  • or aapJ, aapQ, aapM and aapP
  • or braC, braD, braE, braF and braG
  • or hutV, hutW and hutX
  • or bgtA and bgtB
  • or BPHYT_RS24000, BPHYT_RS24005, BPHYT_RS24010 and BPHYT_RS24015
  • or permease
  • or Ga0059261_1577
  • or S15A3
  • or LAT2
  • or LHT
  • or SLC38A3
  • or PTR2
  • Comment: Transporters were identified using query: transporter:histidine:L-histidine:his

48 steps (32 with candidates)

Or see definitions of steps

Step	Description	Best candidate	2nd candidate
aapJ	L-histidine ABC transporter, substrate-binding component AapJ	RSPH17029_RS18145	RSPH17029_RS02000
aapQ	L-histidine ABC transporter, permease component 1 (AapQ)	RSPH17029_RS18140	RSPH17029_RS02005
aapM	L-histidine ABC transporter, permease component 2 (AapM)	RSPH17029_RS18135	RSPH17029_RS02010
aapP	L-histidine ABC transporter, ATPase component AapP	RSPH17029_RS02015	RSPH17029_RS18130
hutH	histidine ammonia-lyase	RSPH17029_RS07990	RSPH17029_RS16390
hutU	urocanase	RSPH17029_RS07995
hutI	imidazole-5-propionate hydrolase	RSPH17029_RS07985
hutF	N-formiminoglutamate deiminase	RSPH17029_RS07980
hutG'	N-formylglutamate amidohydrolase	RSPH17029_RS00345
Alternative steps:
Ac3H11_2554	ABC transporter for L-Histidine, permease component 2	RSPH17029_RS17505	RSPH17029_RS18140
Ac3H11_2555	L-histidine ABC transporter, substrate-binding component 2
Ac3H11_2560	L-histidine ABC transporter, ATPase component	RSPH17029_RS18255	RSPH17029_RS09180
Ac3H11_2561	L-histidine ABC transporter, permease component 1
Ac3H11_2562	L-histidine ABC transporter, substrate-binding component 1
bgtA	L-histidine ABC transporter, ATPase component BgtA	RSPH17029_RS02015	RSPH17029_RS15640
bgtB	L-histidine ABC transporter, fused substrate-binding and permease components (BgtB/BgtAB)
BPHYT_RS24000	L-histidine ABC transporter, substrate-binding component	RSPH17029_RS10170
BPHYT_RS24005	L-histidine ABC transporter, permease component 1	RSPH17029_RS17505
BPHYT_RS24010	L-histidine ABC transporter, permease component 2	RSPH17029_RS17505	RSPH17029_RS10180
BPHYT_RS24015	L-histidine ABC transporter, ATPase component	RSPH17029_RS10165	RSPH17029_RS17510
braC	ABC transporter for glutamate, histidine, arginine, and other amino acids, substrate-binding component BraC
braD	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 1 (BraD)	RSPH17029_RS17970	RSPH17029_RS14875
braE	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 2 (BraE)	RSPH17029_RS04845	RSPH17029_RS14870
braF	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 1 (BraF)	RSPH17029_RS04855	RSPH17029_RS17980
braG	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 2 (BraG)	RSPH17029_RS04835	RSPH17029_RS17985
Ga0059261_1577	L-histidine transporter
hisJ	L-histidine ABC transporter, substrate-binding component HisJ	RSPH17029_RS10170	RSPH17029_RS17495
hisM	L-histidine ABC transporter, permease component 1 (HisM)	RSPH17029_RS10180	RSPH17029_RS17505
hisP	L-histidine ABC transporter, ATPase component HisP	RSPH17029_RS10165	RSPH17029_RS17510
hisQ	L-histidine ABC transporter, permease component 2 (HisQ)	RSPH17029_RS17505	RSPH17029_RS10175
hutG	N-formiminoglutamate formiminohydrolase
hutV	L-histidine ABC transporter, ATPase component HutV	RSPH17029_RS19130	RSPH17029_RS04330
hutW	L-histidine ABC transporter, permease component HutW	RSPH17029_RS19135	RSPH17029_RS04335
hutX	L-histidine ABC transporter, substrate-binding component HutX
LAT2	L-histidine transporter
LHT	L-histidine transporter
natA	L-histidine ABC transporter, ATPase component 1 (NatA)	RSPH17029_RS07935	RSPH17029_RS14865
natB	L-histidine ABC transporter, substrate-binding component NatB
natC	L-histidine ABC transporter, permease component 1 (NatC)
natD	L-histidine ABC transporter, permease component 2 (NatD)	RSPH17029_RS07945	RSPH17029_RS17970
natE	L-histidine ABC transporter, ATPase component 2 (NatE)	RSPH17029_RS07940	RSPH17029_RS04835
PA5503	L-histidine ABC transporter, ATPase component	RSPH17029_RS08935	RSPH17029_RS15640
PA5504	L-histidine ABC transporter, permease component	RSPH17029_RS08940
PA5505	L-histidine ABC transporter, substrate-binding component	RSPH17029_RS08945
permease	L-histidine permease
PTR2	L-histidine:H+ symporter
S15A3	L-histidine transporter
SLC38A3	L-histidine:Na+ symporter

Confidence: high confidence medium confidence low confidence
transporter – transporters and PTS systems are shaded because predicting their specificity is particularly challenging.

This GapMind analysis is from Apr 10 2024. The underlying query database was built on Sep 17 2021.