L-histidine catabolism in Pseudovibrio axinellae Ad2

Best path

braC, braD, braE, braF, braG, hutH, hutU, hutI, hutF, hutG'

Rules

Overview: Histidine utilization in GapMind is based on MetaCyc pathways L-histidine degradation I (link) or II (link). These pathways are very similar. Other pathways in MetaCyc (III-VI) are not complete or are not reported in prokaryotes, so they are not included.

• all:
  • histidine-transport, hutH, hutU, hutI and hutG
  • or histidine-transport, hutH, hutU, hutI, hutH, hutF and hutG'
  • Comment: In pathway I, hutH deaminates histidine to urocanate, hutU hydrates it to 4-imidazolone-5-propanoate, hutI hydrolyzes it to N-formiminoglutamate, and hutG hydrolyzes it to formamide and glutamate. Formamide can be cleaved to formate and ammonia, but it could also be secreted, so this is not described. Similarly, formate may be oxidized to CO2 or secreted. Pathway II also involves conversion to N-formiminoglutamate, but then it is deaminated to N-formylglutamate by hutF, and hydrolyzed to formate and glutamate by hutG'.
• histidine-transport:
  • hisP, hisM, hisQ and hisJ
  • or PA5503, PA5504 and PA5505
  • or Ac3H11_2562, Ac3H11_2561, Ac3H11_2560, Ac3H11_2555 and Ac3H11_2554
  • or natA, natB, natC, natD and natE
  • or aapJ, aapQ, aapM and aapP
  • or braC, braD, braE, braF and braG
  • or hutV, hutW and hutX
  • or bgtA and bgtB
  • or BPHYT_RS24000, BPHYT_RS24005, BPHYT_RS24010 and BPHYT_RS24015
  • or permease
  • or Ga0059261_1577
  • or S15A3
  • or LAT2
  • or LHT
  • or SLC38A3
  • or PTR2
  • Comment: Transporters were identified using query: transporter:histidine:L-histidine:his

48 steps (34 with candidates)

Or see definitions of steps

Step	Description	Best candidate	2nd candidate
braC	ABC transporter for glutamate, histidine, arginine, and other amino acids, substrate-binding component BraC	PsAD2_RS02810
braD	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 1 (BraD)	PsAD2_RS02835
braE	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 2 (BraE)	PsAD2_RS02830	PsAD2_RS08280
braF	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 1 (BraF)	PsAD2_RS02825	PsAD2_RS06010
braG	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 2 (BraG)	PsAD2_RS02820	PsAD2_RS08270
hutH	histidine ammonia-lyase	PsAD2_RS00660
hutU	urocanase	PsAD2_RS00670
hutI	imidazole-5-propionate hydrolase	PsAD2_RS00655
hutF	N-formiminoglutamate deiminase	PsAD2_RS00650
hutG'	N-formylglutamate amidohydrolase	PsAD2_RS00665	PsAD2_RS06165
Alternative steps:
aapJ	L-histidine ABC transporter, substrate-binding component AapJ	PsAD2_RS01035
aapM	L-histidine ABC transporter, permease component 2 (AapM)	PsAD2_RS01045	PsAD2_RS20750
aapP	L-histidine ABC transporter, ATPase component AapP	PsAD2_RS01050	PsAD2_RS05610
aapQ	L-histidine ABC transporter, permease component 1 (AapQ)	PsAD2_RS01040
Ac3H11_2554	ABC transporter for L-Histidine, permease component 2	PsAD2_RS07385	PsAD2_RS20755
Ac3H11_2555	L-histidine ABC transporter, substrate-binding component 2
Ac3H11_2560	L-histidine ABC transporter, ATPase component	PsAD2_RS00630	PsAD2_RS05920
Ac3H11_2561	L-histidine ABC transporter, permease component 1	PsAD2_RS00635
Ac3H11_2562	L-histidine ABC transporter, substrate-binding component 1
bgtA	L-histidine ABC transporter, ATPase component BgtA	PsAD2_RS01050	PsAD2_RS05610
bgtB	L-histidine ABC transporter, fused substrate-binding and permease components (BgtB/BgtAB)
BPHYT_RS24000	L-histidine ABC transporter, substrate-binding component	PsAD2_RS20735	PsAD2_RS20745
BPHYT_RS24005	L-histidine ABC transporter, permease component 1	PsAD2_RS13420	PsAD2_RS20750
BPHYT_RS24010	L-histidine ABC transporter, permease component 2	PsAD2_RS20755	PsAD2_RS13415
BPHYT_RS24015	L-histidine ABC transporter, ATPase component	PsAD2_RS01050	PsAD2_RS05610
Ga0059261_1577	L-histidine transporter
hisJ	L-histidine ABC transporter, substrate-binding component HisJ	PsAD2_RS20740	PsAD2_RS20735
hisM	L-histidine ABC transporter, permease component 1 (HisM)	PsAD2_RS20755	PsAD2_RS13415
hisP	L-histidine ABC transporter, ATPase component HisP	PsAD2_RS01050	PsAD2_RS05610
hisQ	L-histidine ABC transporter, permease component 2 (HisQ)	PsAD2_RS20750	PsAD2_RS13420
hutG	N-formiminoglutamate formiminohydrolase
hutV	L-histidine ABC transporter, ATPase component HutV	PsAD2_RS15670	PsAD2_RS08890
hutW	L-histidine ABC transporter, permease component HutW	PsAD2_RS15675	PsAD2_RS08885
hutX	L-histidine ABC transporter, substrate-binding component HutX	PsAD2_RS15680
LAT2	L-histidine transporter
LHT	L-histidine transporter
natA	L-histidine ABC transporter, ATPase component 1 (NatA)	PsAD2_RS07405	PsAD2_RS09805
natB	L-histidine ABC transporter, substrate-binding component NatB	PsAD2_RS07425
natC	L-histidine ABC transporter, permease component 1 (NatC)
natD	L-histidine ABC transporter, permease component 2 (NatD)	PsAD2_RS07415
natE	L-histidine ABC transporter, ATPase component 2 (NatE)	PsAD2_RS07410	PsAD2_RS02820
PA5503	L-histidine ABC transporter, ATPase component	PsAD2_RS05610	PsAD2_RS15670
PA5504	L-histidine ABC transporter, permease component
PA5505	L-histidine ABC transporter, substrate-binding component
permease	L-histidine permease
PTR2	L-histidine:H+ symporter
S15A3	L-histidine transporter
SLC38A3	L-histidine:Na+ symporter

Confidence: high confidence medium confidence low confidence
transporter – transporters and PTS systems are shaded because predicting their specificity is particularly challenging.

This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.