L-histidine catabolism in Pandoraea thiooxydans ATSB16

Best path

permease, hutH, hutU, hutI, hutF, hutG'

Rules

Overview: Histidine utilization in GapMind is based on MetaCyc pathways L-histidine degradation I (link) or II (link). These pathways are very similar. Other pathways in MetaCyc (III-VI) are not complete or are not reported in prokaryotes, so they are not included.

• all:
  • histidine-transport, hutH, hutU, hutI and hutG
  • or histidine-transport, hutH, hutU, hutI, hutH, hutF and hutG'
  • Comment: In pathway I, hutH deaminates histidine to urocanate, hutU hydrates it to 4-imidazolone-5-propanoate, hutI hydrolyzes it to N-formiminoglutamate, and hutG hydrolyzes it to formamide and glutamate. Formamide can be cleaved to formate and ammonia, but it could also be secreted, so this is not described. Similarly, formate may be oxidized to CO2 or secreted. Pathway II also involves conversion to N-formiminoglutamate, but then it is deaminated to N-formylglutamate by hutF, and hydrolyzed to formate and glutamate by hutG'.
• histidine-transport:
  • hisP, hisM, hisQ and hisJ
  • or PA5503, PA5504 and PA5505
  • or Ac3H11_2562, Ac3H11_2561, Ac3H11_2560, Ac3H11_2555 and Ac3H11_2554
  • or natA, natB, natC, natD and natE
  • or aapJ, aapQ, aapM and aapP
  • or braC, braD, braE, braF and braG
  • or hutV, hutW and hutX
  • or bgtA and bgtB
  • or BPHYT_RS24000, BPHYT_RS24005, BPHYT_RS24010 and BPHYT_RS24015
  • or permease
  • or Ga0059261_1577
  • or S15A3
  • or LAT2
  • or LHT
  • or SLC38A3
  • or PTR2
  • Comment: Transporters were identified using query: transporter:histidine:L-histidine:his

48 steps (35 with candidates)

Or see definitions of steps

Step	Description	Best candidate	2nd candidate
permease	L-histidine permease	PATSB16_RS09985	PATSB16_RS06000
hutH	histidine ammonia-lyase	PATSB16_RS08615
hutU	urocanase	PATSB16_RS08620
hutI	imidazole-5-propionate hydrolase	PATSB16_RS08630
hutF	N-formiminoglutamate deiminase	PATSB16_RS08635
hutG'	N-formylglutamate amidohydrolase	PATSB16_RS08640
Alternative steps:
aapJ	L-histidine ABC transporter, substrate-binding component AapJ
aapM	L-histidine ABC transporter, permease component 2 (AapM)	PATSB16_RS07000	PATSB16_RS17675
aapP	L-histidine ABC transporter, ATPase component AapP	PATSB16_RS15000	PATSB16_RS15715
aapQ	L-histidine ABC transporter, permease component 1 (AapQ)	PATSB16_RS14995
Ac3H11_2554	ABC transporter for L-Histidine, permease component 2	PATSB16_RS13415	PATSB16_RS18540
Ac3H11_2555	L-histidine ABC transporter, substrate-binding component 2	PATSB16_RS13420	PATSB16_RS06995
Ac3H11_2560	L-histidine ABC transporter, ATPase component	PATSB16_RS05860	PATSB16_RS04035
Ac3H11_2561	L-histidine ABC transporter, permease component 1	PATSB16_RS13895	PATSB16_RS07880
Ac3H11_2562	L-histidine ABC transporter, substrate-binding component 1
bgtA	L-histidine ABC transporter, ATPase component BgtA	PATSB16_RS07005	PATSB16_RS01415
bgtB	L-histidine ABC transporter, fused substrate-binding and permease components (BgtB/BgtAB)
BPHYT_RS24000	L-histidine ABC transporter, substrate-binding component	PATSB16_RS18535
BPHYT_RS24005	L-histidine ABC transporter, permease component 1	PATSB16_RS08590	PATSB16_RS13415
BPHYT_RS24010	L-histidine ABC transporter, permease component 2	PATSB16_RS13415	PATSB16_RS05360
BPHYT_RS24015	L-histidine ABC transporter, ATPase component	PATSB16_RS08600	PATSB16_RS01415
braC	ABC transporter for glutamate, histidine, arginine, and other amino acids, substrate-binding component BraC	PATSB16_RS00990	PATSB16_RS05680
braD	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 1 (BraD)	PATSB16_RS00995	PATSB16_RS05685
braE	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 2 (BraE)	PATSB16_RS01000	PATSB16_RS05690
braF	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 1 (BraF)	PATSB16_RS05695	PATSB16_RS12750
braG	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 2 (BraG)	PATSB16_RS01010	PATSB16_RS05700
Ga0059261_1577	L-histidine transporter
hisJ	L-histidine ABC transporter, substrate-binding component HisJ	PATSB16_RS18535	PATSB16_RS05365
hisM	L-histidine ABC transporter, permease component 1 (HisM)	PATSB16_RS13415	PATSB16_RS05360
hisP	L-histidine ABC transporter, ATPase component HisP	PATSB16_RS08600	PATSB16_RS14910
hisQ	L-histidine ABC transporter, permease component 2 (HisQ)	PATSB16_RS10375	PATSB16_RS01410
hutG	N-formiminoglutamate formiminohydrolase	PATSB16_RS13405	PATSB16_RS14245
hutV	L-histidine ABC transporter, ATPase component HutV	PATSB16_RS15330	PATSB16_RS18610
hutW	L-histidine ABC transporter, permease component HutW	PATSB16_RS15335	PATSB16_RS04025
hutX	L-histidine ABC transporter, substrate-binding component HutX
LAT2	L-histidine transporter
LHT	L-histidine transporter
natA	L-histidine ABC transporter, ATPase component 1 (NatA)	PATSB16_RS03645	PATSB16_RS12750
natB	L-histidine ABC transporter, substrate-binding component NatB
natC	L-histidine ABC transporter, permease component 1 (NatC)
natD	L-histidine ABC transporter, permease component 2 (NatD)	PATSB16_RS03635	PATSB16_RS05685
natE	L-histidine ABC transporter, ATPase component 2 (NatE)	PATSB16_RS03650	PATSB16_RS05700
PA5503	L-histidine ABC transporter, ATPase component	PATSB16_RS17690	PATSB16_RS01415
PA5504	L-histidine ABC transporter, permease component	PATSB16_RS15335
PA5505	L-histidine ABC transporter, substrate-binding component
PTR2	L-histidine:H+ symporter
S15A3	L-histidine transporter
SLC38A3	L-histidine:Na+ symporter

Confidence: high confidence medium confidence low confidence
transporter – transporters and PTS systems are shaded because predicting their specificity is particularly challenging.

This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.