L-histidine catabolism in Pseudomonas baetica a390

Best path

hisP, hisM, hisQ, hisJ, hutH, hutU, hutI, hutF, hutG'

Rules

Overview: Histidine utilization in GapMind is based on MetaCyc pathways L-histidine degradation I (link) or II (link). These pathways are very similar. Other pathways in MetaCyc (III-VI) are not complete or are not reported in prokaryotes, so they are not included.

• all:
  • histidine-transport, hutH, hutU, hutI and hutG
  • or histidine-transport, hutH, hutU, hutI, hutH, hutF and hutG'
  • Comment: In pathway I, hutH deaminates histidine to urocanate, hutU hydrates it to 4-imidazolone-5-propanoate, hutI hydrolyzes it to N-formiminoglutamate, and hutG hydrolyzes it to formamide and glutamate. Formamide can be cleaved to formate and ammonia, but it could also be secreted, so this is not described. Similarly, formate may be oxidized to CO2 or secreted. Pathway II also involves conversion to N-formiminoglutamate, but then it is deaminated to N-formylglutamate by hutF, and hydrolyzed to formate and glutamate by hutG'.
• histidine-transport:
  • hisP, hisM, hisQ and hisJ
  • or PA5503, PA5504 and PA5505
  • or Ac3H11_2562, Ac3H11_2561, Ac3H11_2560, Ac3H11_2555 and Ac3H11_2554
  • or natA, natB, natC, natD and natE
  • or aapJ, aapQ, aapM and aapP
  • or braC, braD, braE, braF and braG
  • or hutV, hutW and hutX
  • or bgtA and bgtB
  • or BPHYT_RS24000, BPHYT_RS24005, BPHYT_RS24010 and BPHYT_RS24015
  • or permease
  • or Ga0059261_1577
  • or S15A3
  • or LAT2
  • or LHT
  • or SLC38A3
  • or PTR2
  • Comment: Transporters were identified using query: transporter:histidine:L-histidine:his

48 steps (36 with candidates)

Or see definitions of steps

Step	Description	Best candidate	2nd candidate
hisP	L-histidine ABC transporter, ATPase component HisP	C0J26_RS01695	C0J26_RS10610
hisM	L-histidine ABC transporter, permease component 1 (HisM)	C0J26_RS01680	C0J26_RS08820
hisQ	L-histidine ABC transporter, permease component 2 (HisQ)	C0J26_RS01685	C0J26_RS08825
hisJ	L-histidine ABC transporter, substrate-binding component HisJ	C0J26_RS01690	C0J26_RS16195
hutH	histidine ammonia-lyase	C0J26_RS02025	C0J26_RS02020
hutU	urocanase	C0J26_RS01995
hutI	imidazole-5-propionate hydrolase	C0J26_RS02030
hutF	N-formiminoglutamate deiminase	C0J26_RS01975
hutG'	N-formylglutamate amidohydrolase	C0J26_RS02035
Alternative steps:
aapJ	L-histidine ABC transporter, substrate-binding component AapJ	C0J26_RS05850
aapM	L-histidine ABC transporter, permease component 2 (AapM)	C0J26_RS05860	C0J26_RS02070
aapP	L-histidine ABC transporter, ATPase component AapP	C0J26_RS05865	C0J26_RS21640
aapQ	L-histidine ABC transporter, permease component 1 (AapQ)	C0J26_RS05855
Ac3H11_2554	ABC transporter for L-Histidine, permease component 2	C0J26_RS02070	C0J26_RS01290
Ac3H11_2555	L-histidine ABC transporter, substrate-binding component 2	C0J26_RS01295	C0J26_RS05820
Ac3H11_2560	L-histidine ABC transporter, ATPase component	C0J26_RS13315	C0J26_RS15410
Ac3H11_2561	L-histidine ABC transporter, permease component 1	C0J26_RS01335	C0J26_RS15405
Ac3H11_2562	L-histidine ABC transporter, substrate-binding component 1
bgtA	L-histidine ABC transporter, ATPase component BgtA	C0J26_RS08810	C0J26_RS10610
bgtB	L-histidine ABC transporter, fused substrate-binding and permease components (BgtB/BgtAB)
BPHYT_RS24000	L-histidine ABC transporter, substrate-binding component	C0J26_RS16195	C0J26_RS01690
BPHYT_RS24005	L-histidine ABC transporter, permease component 1	C0J26_RS08825	C0J26_RS01685
BPHYT_RS24010	L-histidine ABC transporter, permease component 2	C0J26_RS10600	C0J26_RS01680
BPHYT_RS24015	L-histidine ABC transporter, ATPase component	C0J26_RS01695	C0J26_RS10610
braC	ABC transporter for glutamate, histidine, arginine, and other amino acids, substrate-binding component BraC	C0J26_RS09040
braD	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 1 (BraD)	C0J26_RS09035
braE	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 2 (BraE)	C0J26_RS09030
braF	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 1 (BraF)	C0J26_RS09025	C0J26_RS03610
braG	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 2 (BraG)	C0J26_RS09020	C0J26_RS03600
Ga0059261_1577	L-histidine transporter
hutG	N-formiminoglutamate formiminohydrolase
hutV	L-histidine ABC transporter, ATPase component HutV	C0J26_RS02015	C0J26_RS28370
hutW	L-histidine ABC transporter, permease component HutW	C0J26_RS02010	C0J26_RS28365
hutX	L-histidine ABC transporter, substrate-binding component HutX	C0J26_RS02005	C0J26_RS12465
LAT2	L-histidine transporter
LHT	L-histidine transporter
natA	L-histidine ABC transporter, ATPase component 1 (NatA)	C0J26_RS09025	C0J26_RS03610
natB	L-histidine ABC transporter, substrate-binding component NatB
natC	L-histidine ABC transporter, permease component 1 (NatC)
natD	L-histidine ABC transporter, permease component 2 (NatD)
natE	L-histidine ABC transporter, ATPase component 2 (NatE)	C0J26_RS09020	C0J26_RS03610
PA5503	L-histidine ABC transporter, ATPase component	C0J26_RS00475	C0J26_RS01255
PA5504	L-histidine ABC transporter, permease component	C0J26_RS00480	C0J26_RS12370
PA5505	L-histidine ABC transporter, substrate-binding component	C0J26_RS00485	C0J26_RS01200
permease	L-histidine permease	C0J26_RS21710	C0J26_RS20455
PTR2	L-histidine:H+ symporter
S15A3	L-histidine transporter
SLC38A3	L-histidine:Na+ symporter

Confidence: high confidence medium confidence low confidence
transporter – transporters and PTS systems are shaded because predicting their specificity is particularly challenging.

This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.