L-histidine catabolism in Rhizobium etli CFN 42

Best path

braC, braD, braE, braF, braG, hutH, hutU, hutI, hutF, hutG'

Rules

Overview: Histidine utilization in GapMind is based on MetaCyc pathways L-histidine degradation I (link) or II (link). These pathways are very similar. Other pathways in MetaCyc (III-VI) are not complete or are not reported in prokaryotes, so they are not included.

• all:
  • histidine-transport, hutH, hutU, hutI and hutG
  • or histidine-transport, hutH, hutU, hutI, hutH, hutF and hutG'
  • Comment: In pathway I, hutH deaminates histidine to urocanate, hutU hydrates it to 4-imidazolone-5-propanoate, hutI hydrolyzes it to N-formiminoglutamate, and hutG hydrolyzes it to formamide and glutamate. Formamide can be cleaved to formate and ammonia, but it could also be secreted, so this is not described. Similarly, formate may be oxidized to CO2 or secreted. Pathway II also involves conversion to N-formiminoglutamate, but then it is deaminated to N-formylglutamate by hutF, and hydrolyzed to formate and glutamate by hutG'.
• histidine-transport:
  • hisP, hisM, hisQ and hisJ
  • or PA5503, PA5504 and PA5505
  • or Ac3H11_2562, Ac3H11_2561, Ac3H11_2560, Ac3H11_2555 and Ac3H11_2554
  • or natA, natB, natC, natD and natE
  • or aapJ, aapQ, aapM and aapP
  • or braC, braD, braE, braF and braG
  • or hutV, hutW and hutX
  • or bgtA and bgtB
  • or BPHYT_RS24000, BPHYT_RS24005, BPHYT_RS24010 and BPHYT_RS24015
  • or permease
  • or Ga0059261_1577
  • or S15A3
  • or LAT2
  • or LHT
  • or SLC38A3
  • or PTR2
  • Comment: Transporters were identified using query: transporter:histidine:L-histidine:his

48 steps (37 with candidates)

Or see definitions of steps

Step	Description	Best candidate	2nd candidate
braC	ABC transporter for glutamate, histidine, arginine, and other amino acids, substrate-binding component BraC	RHE_RS16985	RHE_RS15140
braD	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 1 (BraD)	RHE_RS17010	RHE_RS16960
braE	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 2 (BraE)	RHE_RS17005
braF	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 1 (BraF)	RHE_RS17000	RHE_RS25470
braG	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 2 (BraG)	RHE_RS16995	RHE_RS25475
hutH	histidine ammonia-lyase	RHE_RS24395	RHE_RS24440
hutU	urocanase	RHE_RS24380	RHE_RS01755
hutI	imidazole-5-propionate hydrolase	RHE_RS24400
hutF	N-formiminoglutamate deiminase	RHE_RS24405
hutG'	N-formylglutamate amidohydrolase	RHE_RS24385	RHE_RS18265
Alternative steps:
aapJ	L-histidine ABC transporter, substrate-binding component AapJ	RHE_RS09695
aapM	L-histidine ABC transporter, permease component 2 (AapM)	RHE_RS09685	RHE_RS23760
aapP	L-histidine ABC transporter, ATPase component AapP	RHE_RS09680	RHE_RS27420
aapQ	L-histidine ABC transporter, permease component 1 (AapQ)	RHE_RS09690	RHE_RS20265
Ac3H11_2554	ABC transporter for L-Histidine, permease component 2	RHE_RS20480	RHE_RS27395
Ac3H11_2555	L-histidine ABC transporter, substrate-binding component 2	RHE_RS20485	RHE_RS12350
Ac3H11_2560	L-histidine ABC transporter, ATPase component	RHE_RS16850	RHE_RS22940
Ac3H11_2561	L-histidine ABC transporter, permease component 1
Ac3H11_2562	L-histidine ABC transporter, substrate-binding component 1
bgtA	L-histidine ABC transporter, ATPase component BgtA	RHE_RS27405	RHE_RS23640
bgtB	L-histidine ABC transporter, fused substrate-binding and permease components (BgtB/BgtAB)
BPHYT_RS24000	L-histidine ABC transporter, substrate-binding component	RHE_RS24420	RHE_RS10970
BPHYT_RS24005	L-histidine ABC transporter, permease component 1	RHE_RS24425	RHE_RS10955
BPHYT_RS24010	L-histidine ABC transporter, permease component 2	RHE_RS24430	RHE_RS10950
BPHYT_RS24015	L-histidine ABC transporter, ATPase component	RHE_RS24435	RHE_RS10945
Ga0059261_1577	L-histidine transporter
hisJ	L-histidine ABC transporter, substrate-binding component HisJ	RHE_RS12350	RHE_RS23645
hisM	L-histidine ABC transporter, permease component 1 (HisM)	RHE_RS30300	RHE_RS10950
hisP	L-histidine ABC transporter, ATPase component HisP	RHE_RS23640	RHE_RS10945
hisQ	L-histidine ABC transporter, permease component 2 (HisQ)	RHE_RS12355	RHE_RS23650
hutG	N-formiminoglutamate formiminohydrolase
hutV	L-histidine ABC transporter, ATPase component HutV	RHE_RS28575	RHE_RS28485
hutW	L-histidine ABC transporter, permease component HutW	RHE_RS28570	RHE_RS15785
hutX	L-histidine ABC transporter, substrate-binding component HutX	RHE_RS28565
LAT2	L-histidine transporter
LHT	L-histidine transporter
natA	L-histidine ABC transporter, ATPase component 1 (NatA)	RHE_RS17000	RHE_RS25470
natB	L-histidine ABC transporter, substrate-binding component NatB	RHE_RS15140
natC	L-histidine ABC transporter, permease component 1 (NatC)
natD	L-histidine ABC transporter, permease component 2 (NatD)	RHE_RS25480
natE	L-histidine ABC transporter, ATPase component 2 (NatE)	RHE_RS16995	RHE_RS25475
PA5503	L-histidine ABC transporter, ATPase component	RHE_RS22810	RHE_RS27405
PA5504	L-histidine ABC transporter, permease component	RHE_RS22805	RHE_RS02455
PA5505	L-histidine ABC transporter, substrate-binding component	RHE_RS22815
permease	L-histidine permease	RHE_RS25845
PTR2	L-histidine:H+ symporter
S15A3	L-histidine transporter
SLC38A3	L-histidine:Na+ symporter

Confidence: high confidence medium confidence low confidence
transporter – transporters and PTS systems are shaded because predicting their specificity is particularly challenging.

This GapMind analysis is from Apr 09 2024. The underlying query database was built on Sep 17 2021.