catabolism of small carbon sources in Sulfuritalea hydrogenivorans DSM 22779

GapMind for catabolism of small carbon sources

catabolism of small carbon sources in Sulfuritalea hydrogenivorans DSM 22779

Pathways are sorted by completeness. Sort by name instead.

Pathway	Steps
phenylalanine	livF, livG, livH, livM, livJ, ARO8, iorAB, padB, padC, padD, padG, padI, padE, padF, padH, bcrA, bcrB, bcrC, bcrD, dch, had, oah, pimB, gcdH, ech, fadB, atoB
isoleucine	livF, livG, livJ, livH, livM, ofo, acdH, ech, ivdG, fadA, pccA, pccB, epi, mcm-large, mcm-small
leucine	livF, livG, livJ, livH, livM, ilvE, ofo, liuA, liuB, liuD, liuC, liuE, aacS, atoB
aspartate	aatJ, aatQ, aatM, aatP
fumarate	dctM, dctP, dctQ
L-malate	dctM, dctP, dctQ
pyruvate	dctM, dctP, dctQ
succinate	dctQ, dctM, dctP
acetate	actP, acs
2-oxoglutarate	Psest_0084, Psest_0085
phenylacetate	ppa, paaK, padB, padC, padD, padG, padI, padE, padF, padH, bcrA, bcrB, bcrC, bcrD, dch, had, oah, pimB, gcdH, ech, fadB, atoB
propionate	mctC, prpE, pccA, pccB, epi, mcm-large, mcm-small
threonine	braC, braD, braE, braF, braG, ltaE, adh, acs, gcvP, gcvT, gcvH, lpd
serine	Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
ethanol	etoh-dh-nad, adh, acs
alanine	braC, braD, braE, braF, braG
valine	livF, livG, livJ, livH, livM, ofo, acdH, ech, bch, mmsB, mmsA, pccA, pccB, epi, mcm-large, mcm-small
4-hydroxybenzoate	pcaK, hcl, hcrA, hcrB, hcrC, bcrA, bcrB, bcrC, bcrD, dch, had, oah, pimB, gcdH, ech, fadB, atoB
tyrosine	Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, HPD, hmgA, maiA, fahA, aacS, atoB
asparagine	ans, aatJ, aatQ, aatM, aatP
glutamate	gltI, gltJ, gltK, gltL, gdhA
proline	HSERO_RS00870, HSERO_RS00885, HSERO_RS00890, HSERO_RS00895, HSERO_RS00900, prdF, prdA, prdB, prdC, davT, davD, gcdG, gcdH, ech, fadB, atoB
glycerol	glpF, glpK, glpD, tpi
D-lactate	lctP, glcD, glcE, glcF
citrate	SLC13A5, acn, icd
lysine	lysP, cadA, patA, patD, davT, davD, gcdG, gcdH, ech, fadB, atoB
sucrose	sut, SUS, scrK, galU, pgmA
D-alanine	cycA, dadA
fructose	Slc2a5, scrK
glucose	MFS-glucose, glk
L-lactate	lctP, L-LDH
mannose	STP6, mannokinase, manA
trehalose	treF, MFS-glucose, glk
cellobiose	cdt, cbp, pgmA, glk
glucose-6-P	uhpT
putrescine	potA, potB, potC, potD, patA, patD, gabT, gabD
maltose	malEIICBA, malA, glk
mannitol	PLT5, mt2d, scrK
sorbitol	SOT, sdh, scrK
glucosamine	gamP, nagB
ribose	rbsU, rbsK
D-serine	cycA, dsdA
tryptophan	aroP, tnaA
xylitol	fruI, x5p-reductase
deoxyribose	deoP, deoK, deoC, adh, acs
galactose	galP, galK, galT, galE, pgmA
deoxyinosine	nupC, deoD, deoB, deoC, adh, acs
thymidine	nupG, deoA, deoB, deoC, adh, acs
deoxyribonate	deoxyribonate-transport, deoxyribonate-dehyd, ketodeoxyribonate-cleavage, garK, aacS, atoB
gluconate	gntT, gntK, gnd
NAG	nagEcba, nagA, nagB
xylose	xylT, xylA, xylB
lactose	lacP, lacZ, galK, galT, galE, pgmA, glk
arginine	rocE, rocF, rocD, rocA
glucuronate	exuT, udh, gci, garL, garR, garK
rhamnose	rhaT, rhaM, rhaA, rhaB, rhaD, tpi, aldA
arabinose	araE, araA, araB, araD
fucose	fucP, fucU, fucI, fucK, fucA, tpi, aldA
histidine	permease, hutH, hutU, hutI, hutG
galacturonate	exuT, udh, gli, gci, kdgD, dopDH
citrulline	AO353_03055, AO353_03050, AO353_03045, AO353_03040, arcB, arcC, rocD, rocA
myoinositol	iolT, iolG, iolE, iolD, iolB, iolC, iolJ, mmsA, tpi

Confidence: high confidence medium confidence low confidence
transporter – transporters and PTS systems are shaded because predicting their specificity is particularly challenging.

This GapMind analysis is from Apr 09 2024. The underlying query database was built on Sep 17 2021.

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Candidates (tab-delimited)
Steps (tab-delimited)
Rules (tab-delimited)
Protein sequences (fasta format)
Organisms (tab-delimited)
SQLite3 databases

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About GapMind

Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.

A candidate for a step is "high confidence" if either:

ublast finds a hit to a characterized protein at above 40% identity and 80% coverage, and bits >= other bits+10.
- (Hits to curated proteins without experimental data as to their function are never considered high confidence.)
HMMer finds a hit with 80% coverage of the model, and either other identity < 40 or other coverage < 0.75.

where "other" refers to the best ublast hit to a sequence that is not annotated as performing this step (and is not "ignored").

Otherwise, a candidate is "medium confidence" if either:

ublast finds a hit at above 40% identity and 70% coverage (ignoring otherBits).
ublast finds a hit at above 30% identity and 80% coverage, and bits >= other bits.
HMMer finds a hit (regardless of coverage or other bits).

Other blast hits with at least 50% coverage are "low confidence."

Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:

our ignorance of proteins' functions,
omissions in the gene models,
frame-shift errors in the genome sequence, or
the organism lacks the pathway.

GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).

For more information, see:

the paper from 2019 on GapMind for amino acid biosynthesis
the paper from 2022 on GapMind for carbon sources
the source code
instructions for running GapMind on your computer

If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know

by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory

GapMind for catabolism of small carbon sources