Align ABC transporter related (characterized, see rationale)
to candidate BPHYT_RS28215 BPHYT_RS28215 D-ribose transporter ATP binding protein
Query= uniprot:A0KWY5 (499 letters) >FitnessBrowser__BFirm:BPHYT_RS28215 Length = 509 Score = 360 bits (924), Expect = e-104 Identities = 193/492 (39%), Positives = 312/492 (63%), Gaps = 7/492 (1%) Query: 5 LELKQISKHYPGVKALEDVSLRLFAGEVHALLGENGAGKSTLVKVMTGAQSKDMGDILFL 64 LEL+ SK + V+AL D L L+ GEVHALLGENGAGKST+VK++ G D G+++ Sbjct: 11 LELRHASKSFGRVRALSDGDLALWPGEVHALLGENGAGKSTVVKILAGVHQPDTGELVVD 70 Query: 65 GEPQHFNTPMDAQKAGISTVYQEVNLVPNLTVAQNLFLGYEP-RRLGLIHFKKMYADARA 123 GE + F TP +A+ AG++ +YQE L +L++A+N+F+G +P R+G I + M + Sbjct: 71 GEARRFATPAEARDAGLAVIYQEPTLFFDLSIAENIFMGRQPVDRIGRIQYDAMRREVDG 130 Query: 124 VLTQFKLDIDVSAPLSDYSIAVQQLIAIARGVAMSAKVLVLDEPTASLDAKEVQVLFGIL 183 +L +D+ + SIA QQ+I IA+ ++++A VL++DEPTA+L EV+ LF I+ Sbjct: 131 LLASLGVDLRADQLVRGLSIADQQVIEIAKALSLNANVLIMDEPTAALSLPEVERLFTIV 190 Query: 184 NQLKAKGVAIVFITHFLDQVYQISDRITVLRNGQFIGEYLTAELPQPKLIEAMLGRSLQE 243 +L+ + VAI+FITH LD+V+ ++ R+T++R+G + + LT +L ++ M+GR L E Sbjct: 191 RKLRERDVAILFITHRLDEVFALTQRVTIMRDGAKVFDGLTTDLNTEAIVAKMVGRDL-E 249 Query: 244 QLVDKQEKERTVTRAEAVLLSLEDVSVKGSIQSMNLTVPKGQAVGLAGLLGSGRSEVCNA 303 K E+ R LS+ ++ G + ++ V G+ V LAGL+G+GRSEV A Sbjct: 250 TFYPKAERPPGEVR-----LSVRGLTRVGVFKDISFDVRAGEIVALAGLVGAGRSEVARA 304 Query: 304 VFGLDLVDSGSIHLAGQKLNLSQPVDAISAGIALCPEDRKIDGIIGPLSIRENIILALQA 363 +FG+D +DSG I +AG++L +P A+ AG+AL PEDR+ G+ LSI N + + Sbjct: 305 IFGIDPLDSGEIWIAGKRLTAGRPAAAVRAGLALVPEDRRQQGLALELSIARNASMTVLG 364 Query: 364 RIGWWRYLSNTRQQEIAQFFIDKLQIATPDADKPIEQLSGGNQQKVILARWLAIEPILLV 423 R+ +S + ++A + +L++ D + P+ LSGGNQQKV+L +WLA P +L+ Sbjct: 365 RLVKHGLISARSETQLANQWGTRLRLKAGDPNAPVGTLSGGNQQKVVLGKWLATGPKVLI 424 Query: 424 LDEPTRGIDIGAHAEIVKLIRTLCDEGMSLLVASSELDELVAFSNKVVVLRDRYAVRELS 483 +DEPTRGID+GA AE+ + L +GM++L+ SSEL E++ +++V+V+ + +++ Sbjct: 425 IDEPTRGIDVGAKAEVYSALAELVRDGMAVLMISSELPEVLGMADRVLVMHEGRISADIA 484 Query: 484 GAELTSQHVMQA 495 A+ + +M A Sbjct: 485 RADADEERIMGA 496 Score = 91.3 bits (225), Expect = 7e-23 Identities = 64/231 (27%), Positives = 117/231 (50%), Gaps = 6/231 (2%) Query: 17 VKALEDVSLRLFAGEVHALLGENGAGKSTLVKVMTGAQSKDMGDILFLGEPQHFNTPMDA 76 V +D+S + AGE+ AL G GAG+S + + + G D G+I G+ P A Sbjct: 272 VGVFKDISFDVRAGEIVALAGLVGAGRSEVARAIFGIDPLDSGEIWIAGKRLTAGRPAAA 331 Query: 77 QKAGISTVYQE---VNLVPNLTVAQNLFLGYEPRRL--GLIHFKKMYADARAVLTQFKLD 131 +AG++ V ++ L L++A+N + R + GLI + A T+ +L Sbjct: 332 VRAGLALVPEDRRQQGLALELSIARNASMTVLGRLVKHGLISARSETQLANQWGTRLRLK 391 Query: 132 I-DVSAPLSDYSIAVQQLIAIARGVAMSAKVLVLDEPTASLDAKEVQVLFGILNQLKAKG 190 D +AP+ S QQ + + + +A KVL++DEPT +D ++ L +L G Sbjct: 392 AGDPNAPVGTLSGGNQQKVVLGKWLATGPKVLIIDEPTRGIDVGAKAEVYSALAELVRDG 451 Query: 191 VAIVFITHFLDQVYQISDRITVLRNGQFIGEYLTAELPQPKLIEAMLGRSL 241 +A++ I+ L +V ++DR+ V+ G+ + A+ + +++ A LG+ + Sbjct: 452 MAVLMISSELPEVLGMADRVLVMHEGRISADIARADADEERIMGAALGQPM 502 Lambda K H 0.319 0.136 0.377 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 625 Number of extensions: 32 Number of successful extensions: 7 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 2 Number of HSP's successfully gapped: 2 Length of query: 499 Length of database: 509 Length adjustment: 34 Effective length of query: 465 Effective length of database: 475 Effective search space: 220875 Effective search space used: 220875 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory