Align Altronate dehydratase; D-altronate hydro-lyase; EC 4.2.1.7 (characterized)
to candidate 350014 BT0486 altronate hydrolase (NCBI ptt file)
Query= SwissProt::P42604 (495 letters) >FitnessBrowser__Btheta:350014 Length = 496 Score = 568 bits (1464), Expect = e-166 Identities = 278/494 (56%), Positives = 359/494 (72%), Gaps = 1/494 (0%) Query: 2 QYIKIHALDNVAVALADLAEGTEVSVDNQTVTLRQDVARGHKFALTDIAKGANVIKYGLP 61 +Y++I+ DNVAVA+ +L G +SVD +TL +D+ GHKFAL D A+G NVIKYG P Sbjct: 4 KYLRINPADNVAVAIVNLPAGEHLSVDGIEITLNEDIPAGHKFALKDFAEGENVIKYGYP 63 Query: 62 IGYALADIAAGVHVHAHNTRTNLSDLDQYRYQPDFQDLPAQAADREVQIYRRANGDVGVR 121 IG+A G ++ N +TNL+ L +Y Y P L + + YRR NGDVGVR Sbjct: 64 IGHARMAKKQGDWMNETNIKTNLAGLLEYTYHPTQVTLDIPHKNLTFKGYRRKNGDVGVR 123 Query: 122 NELWILPTVGCVNGIARQIQNRFLKETNNAEGTDGVFLFSHTYGCSQLGDDHINTRTMLQ 181 NE+WI+PTVGCVNGI Q+ +ET +G D + F H YGCSQLGDDH NT+ +L+ Sbjct: 124 NEIWIIPTVGCVNGIIGQLAEGLRRETEG-KGVDAIVAFPHNYGCSQLGDDHENTKKILR 182 Query: 182 NMVRHPNAGAVLVIGLGCENNQVAAFRETLGDIDPERVHFMICQQQDDEIEAGIEHLHQL 241 +MV HPNAGAVL++GLGCENNQ FRE LGD D +RV FM+ Q+ DE E G++ L L Sbjct: 183 DMVLHPNAGAVLIVGLGCENNQPDVFREFLGDYDQDRVKFMVTQKVGDEYEEGMDILRDL 242 Query: 242 YNVMRNDKREPGKLSELKFGLECGGSDGLSGITANPMLGRFSDYVIANGGTTVLTEVPEM 301 Y D+R LSEL+ GL+CGGSDG SGITANP+LG FSD++IA GGT+VLTEVPEM Sbjct: 243 YAKASKDERTEVPLSELRVGLKCGGSDGFSGITANPLLGMFSDFLIAQGGTSVLTEVPEM 302 Query: 302 FGAEQLLMDHCRDEATFEKLVTMVNDFKQYFIAHDQPIYENPSPGNKAGGITTLEDKSLG 361 FGAE +LM+ C ++ FE+ V ++NDFK+YF++H +P+ ENPSPGNKAGGI+TLE+K+LG Sbjct: 303 FGAETILMNRCENKDLFEQTVHLINDFKEYFLSHGEPVGENPSPGNKAGGISTLEEKALG 362 Query: 362 CTQKAGSSVVVDVLRYGERLKTPGLNLLSAPGNDAVATSALAGAGCHMVLFSTGRGTPYG 421 CTQK G S V V+ YGERL+ GLNLLSAPGND VA + LA +GCHMVLF+TGRGTP+G Sbjct: 363 CTQKCGKSYVSGVMPYGERLQKKGLNLLSAPGNDLVAATTLAASGCHMVLFTTGRGTPFG 422 Query: 422 GFVPTVKIATNSELAAKKKHWIDFDAGQLIHGKAMPQLLEEFIDTIVEFANGKQTCNERN 481 FVPT+KI+TNS LA K WIDF+AG ++ + M + E FI+ +++ A+G+ NE+ Sbjct: 423 TFVPTMKISTNSTLAKNKPGWIDFNAGVIVENEPMEKTCERFIEYVIKVASGEFVNNEKK 482 Query: 482 DFRELAIFKSGVTL 495 +RE+AIFK+GVTL Sbjct: 483 GYREIAIFKTGVTL 496 Lambda K H 0.319 0.136 0.403 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 753 Number of extensions: 32 Number of successful extensions: 2 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 495 Length of database: 496 Length adjustment: 34 Effective length of query: 461 Effective length of database: 462 Effective search space: 212982 Effective search space used: 212982 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory