Align Acetate/haloacid transporter, Dehp2, with a possible atypical topology (characterized)
to candidate H281DRAFT_04211 H281DRAFT_04211 Predicted arabinose efflux permease, MFS family
Query= TCDB::F8SVK1 (552 letters) >FitnessBrowser__Burk376:H281DRAFT_04211 Length = 552 Score = 1008 bits (2607), Expect = 0.0 Identities = 498/552 (90%), Positives = 527/552 (95%) Query: 1 MATVSGQISHAPMTKEEKRVIFASSLGTVFEWYDFYLAGSLAAFISKSFFSGVNPTAAFI 60 MATV G IS PMT++EKRVIFASSLGTVFEWYDFYLAGSLAAFISKSFFSGVNPTA FI Sbjct: 1 MATVGGHISPVPMTRDEKRVIFASSLGTVFEWYDFYLAGSLAAFISKSFFSGVNPTAGFI 60 Query: 61 FTLLGFAAGFAVRPFGALVFGRLGDMVGRKYTFLITIVIMGLSTCVVGFLPGYAAIGMAS 120 FTLL FAAGFAVRPFGA+VFGRLGDMVGRKYTFL+TIVIMGLST +VGFLPGYAAIG+AS Sbjct: 61 FTLLSFAAGFAVRPFGAVVFGRLGDMVGRKYTFLVTIVIMGLSTFLVGFLPGYAAIGIAS 120 Query: 121 PVIFIAMRLLQGLALGGEYGGAATYVAEHAPANRRGFYTAWIQTTATLGLFLSLLVILGV 180 PVIFIAMR+LQGLALGGEYGGAATYVAEHAP RRGFYTAWIQTTATLGLFLSLLVILGV Sbjct: 121 PVIFIAMRMLQGLALGGEYGGAATYVAEHAPPGRRGFYTAWIQTTATLGLFLSLLVILGV 180 Query: 181 RTAMGEDAFGAWGWRIPFVASLVLLGISVWIRMQLHESPAFERIKAEGKTSKAPLSEAFG 240 RTAMGEDAFGAWGWRIPF+AS++LLG+SVWIR+QLHESP FERIKAEGKTSKAPLSEAFG Sbjct: 181 RTAMGEDAFGAWGWRIPFIASILLLGVSVWIRLQLHESPVFERIKAEGKTSKAPLSEAFG 240 Query: 241 QWKNLKIVILALIGVTAGQAVVWYTGQFYALFFLTQTLKVDGASANILIAIALLIGTPFF 300 QWKNLK+VILALIG+TAGQAVVWYTGQFY LFFLTQTLKVDGA+ANI+IAIALLIGTPFF Sbjct: 241 QWKNLKVVILALIGLTAGQAVVWYTGQFYTLFFLTQTLKVDGATANIMIAIALLIGTPFF 300 Query: 301 LFFGSLSDRIGRKPIILAGCLIAALTYFPLFKALTHYANPALEAATQKSPIVVIANPDEC 360 LFFGSLSDRIGRKPII+AG LIAALTYFPLFKALTHY NPALE AT K+PIVVIANPDEC Sbjct: 301 LFFGSLSDRIGRKPIIMAGLLIAALTYFPLFKALTHYVNPALETATAKAPIVVIANPDEC 360 Query: 361 SFQFNPVGTSKFTSSCDIAKSALSKAGLNYDNVAAPAGTLAQIKVGDTTIDTYDGKAADA 420 SFQFNPVGTSKFTSSCDIAKSALSK+GLNY+NVAAP GTLAQIKVGDT + TYDGKAADA Sbjct: 361 SFQFNPVGTSKFTSSCDIAKSALSKSGLNYENVAAPVGTLAQIKVGDTVVSTYDGKAADA 420 Query: 421 KDAGKAFDKNLGTALKAASYPPKADPSQLNWPMTVVILTILVIYVTMVYGPIAAMLVEMF 480 KD GK FDK+L T LK+A YPPKAD SQ+NWPM+VVILTILVIYVTMVYGPIAAMLVEMF Sbjct: 421 KDQGKVFDKSLSTTLKSAGYPPKADSSQINWPMSVVILTILVIYVTMVYGPIAAMLVEMF 480 Query: 481 PTRIRYTSMSLPYHIGNGWFGGFLPATAFAIVAAKGNIYSGLWYPIIIALATFVIGLLFV 540 PTRIRYTSMSLPYHIGNGWFGGFLPATAFAIVAAKGNIYSGLWYPI+IAL TFVIG+LFV Sbjct: 481 PTRIRYTSMSLPYHIGNGWFGGFLPATAFAIVAAKGNIYSGLWYPIVIALITFVIGMLFV 540 Query: 541 RETKDSNIYAQD 552 RETKDS+IYA+D Sbjct: 541 RETKDSDIYAKD 552 Lambda K H 0.325 0.139 0.422 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 1069 Number of extensions: 39 Number of successful extensions: 3 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 552 Length of database: 552 Length adjustment: 36 Effective length of query: 516 Effective length of database: 516 Effective search space: 266256 Effective search space used: 266256 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 53 (25.0 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory