Align Alcohol dehydrogenase (quinone), dehydrogenase subunit; ADH; Alcohol dehydrogenase (quinone), acceptor subunit; Alcohol dehydrogenase (quinone), subunit I; Ethanol:Q2 reductase; G3-ADH subunit I; Quinohemoprotein alcohol dehydrogenase; Quinohemoprotein-cytochrome c complex; Ubiquinol oxidase; EC 1.1.5.5 (characterized)
to candidate H281DRAFT_00328 H281DRAFT_00328 alcohol dehydrogenase (cytochrome c)
Query= SwissProt::P28036 (738 letters) >FitnessBrowser__Burk376:H281DRAFT_00328 Length = 575 Score = 306 bits (785), Expect = 1e-87 Identities = 200/610 (32%), Positives = 296/610 (48%), Gaps = 44/610 (7%) Query: 8 KRRSLS--RTLTAGTICAALIS-GYATMASADDGQGATGEAIIHADDHPGNWMTYGRTYS 64 K RS+S R T AA++S AT A ADD T + + A PG W+TY RTY+ Sbjct: 2 KARSISVLRPRALATSVAAVVSLSCATAAFADDYPAVTYDRLSAAQSDPG-WLTYYRTYN 60 Query: 65 DQRYSPLDQINRSNVGNLKLAWYLDL--DTNRGQEGTPLVIDGVMYATTNWSMMKAVDAA 122 Q +SPL QI+ SNV LK W D +G E TP+V ++ TT + A DAA Sbjct: 61 GQAHSPLKQIDTSNVKQLKQVWSYKFPADLQQGFEATPIVNGHYLFVTTPKDNVYAFDAA 120 Query: 123 TGKLLWSYDPRVPGNIADKGCCDTVNRGAAYWNGKVYFGTFDGRLIALDAKTGKLVWSVN 182 +GK LW ++P++ CCD +NRG A + VY +G ++ALDA+TG L W Sbjct: 121 SGKQLWKFEPKLGAESFKTACCDVINRGVALYGKNVYVAMLNGEVVALDAQTGSLAWRKT 180 Query: 183 TIPPEAELGKQRSYTVDGAPRIAKGRVIIGNGGSEFGARGFVSAFDAETGKVDWRFFTVP 242 P Y AP G +++G+ G E+GARGF++A + + G V W+ FTVP Sbjct: 181 MFEPGV------GYAFSLAPLAIDGALVVGSAGGEYGARGFIAALNPDNGNVLWKRFTVP 234 Query: 243 NPKNEPDAASDSVLMNKAYQTWSPTGAWTRQGGGGTVWDSIVYDPVADLVYLGVGNGSPW 302 AA + K TW P G ++ GG W + YD + +Y GVGN PW Sbjct: 235 -------AAGE-----KGANTW-PDG--MQEHGGAPAWLTGTYDAASRTLYWGVGNPGPW 279 Query: 303 NYKYRSEGKGDNLFLGSIVALKPETGEYVWHFQETPMDQWDFTSDQQIMTLDLPINGETR 362 R GDNL+ S++AL P+TG+ WH+Q T D WD+ + ++ + Sbjct: 280 LADLR---PGDNLYSDSLLALDPKTGDLKWHYQYTKHDTWDYDGVNTPVLANIKYQDKNY 336 Query: 363 HVIVHARKNGFFYIIDAKTGEFISGKNYVYVNWASGLDPKTGRPIYNPDALYTLTGKEWY 422 I+HA +NG+F+ ID TG+ I K +V +G G P+ +P + Y TG Sbjct: 337 DAIIHADRNGYFHAIDRGTGKLIYAKPFVKATSVTGY-TADGVPVQDP-SKYPKTGTTIE 394 Query: 423 GIPGDLGGHNFAAMAFSPKTGLVYIPAQQVPFLYTNQVGGFTPHPDSWNLGLDMNKVGIP 482 P LGG N+ ++++ P + +PA + + ++ GL G Sbjct: 395 TCPSFLGGKNWWSVSYDPDRQVAIVPALHACMSLSGK-------SVTYMEGLPYLGEGFE 447 Query: 483 DSPEAKQAFVKDLKGWIVAWDPQKQAEAWRVDHKGPWNGGILATGGDLLFQGLANGEFHA 542 PE +L+ A D + W K PWNGG+ T L F G +G +A Sbjct: 448 IKPEPGSKGYGELQ----AIDVTTGKKMWSYWSKLPWNGGVATTASGLAFSGSLDGHLYA 503 Query: 543 YDATNGSDLFHF-AADSGIIAPPVTYLANGKQYVAVEVGWGGIYPFFLGGLARTSGWTVN 601 +D++ G L+ SGI+A P + +GK+YVA+ G+GG P + G +A+ + Sbjct: 504 FDSSTGKVLWKSPKLASGIVAQPSVFEVDGKEYVAILAGYGGANPIWGGPMAKAAEKIPR 563 Query: 602 HSRIIAFSLD 611 + F+L+ Sbjct: 564 GGTLYVFALN 573 Lambda K H 0.318 0.137 0.440 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 1610 Number of extensions: 137 Number of successful extensions: 24 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 738 Length of database: 575 Length adjustment: 38 Effective length of query: 700 Effective length of database: 537 Effective search space: 375900 Effective search space used: 375900 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 54 (25.4 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory