Align Inositol transport system ATP-binding protein (characterized)
to candidate H281DRAFT_00426 H281DRAFT_00426 monosaccharide ABC transporter ATP-binding protein, CUT2 family
Query= reanno::WCS417:GFF2332 (517 letters) >FitnessBrowser__Burk376:H281DRAFT_00426 Length = 503 Score = 458 bits (1178), Expect = e-133 Identities = 245/492 (49%), Positives = 334/492 (67%), Gaps = 3/492 (0%) Query: 23 LLEIVNISKGFPGVVALADVQLRVRPGTVLALMGENGAGKSTLMKIIAGIYQPDAGEIRL 82 L+ + +SK FPGV AL DVQ + G V ALMGENGAGKSTLMKI+AG+Y D+GEI L Sbjct: 4 LISVKKLSKSFPGVRALHDVQFDLVEGEVHALMGENGAGKSTLMKILAGVYTRDSGEILL 63 Query: 83 RGKPIVFETPLAAQKAGIAMIHQELNLMPHMSIAENIWIGREQLNSLHM-VNHREMHRCT 141 G+P+ ++P AQ AGI +IHQEL LM H+++A+NI+IGRE L + ++ +++ Sbjct: 64 GGQPVELQSPRDAQAAGIGIIHQELQLMNHLTVAQNIFIGREPRGRLGLFLDEDKLNAKA 123 Query: 142 AELLARLRINLDPEEQVGNLSIAERQMVEIAKAVSYDSDILIMDEPTSAITEKEVAHLFS 201 E+L+R+ +N+DP VGNL++A +QMVEIAKA+S+DS +LIMDEPTSA+ + E+A LF Sbjct: 124 REILSRMHVNIDPRAMVGNLTVASQQMVEIAKALSFDSRVLIMDEPTSALNDAEIAELFR 183 Query: 202 IIADLKSQGKGIVYITHKMNEVFAIADEVAVFRDGHYIGLQRADSMNSDSLISMMVGREL 261 II +LK +G G+VYI+HKM+E+ IAD V V RDG Y+ A + +++I MMVGR L Sbjct: 184 IIRELKQRGVGVVYISHKMDELKQIADRVTVLRDGEYVATVAAADTSVEAIIGMMVGRTL 243 Query: 262 SQLFPL-RETPIGDLLLTVRDLTLDGVFKDVSFDLHAGEILGIAGLMGSGRTNVAETIFG 320 S + P R G++ L VR+L + +DVSF L GEILG AGLMG+GRT VA +FG Sbjct: 244 SDVAPAGRAASQGEIALEVRNLHAGPLVRDVSFTLRKGEILGFAGLMGAGRTEVARAVFG 303 Query: 321 ITPSSSGQITLDGKAVRISDPHMAIEKGFALLTEDRKLSGLFPCLSVLENMEMAVLPHYT 380 P SG+I + G I P A+ G L+EDRK GL + V N+ M+ L ++ Sbjct: 304 ADPVESGEIFVKGAKASIRTPSDAVAHGIGYLSEDRKRFGLATGMDVESNIVMSNLRNFL 363 Query: 381 G-NGFIQQKALRALCEDMCKKLRVKTPSLEQCIDTLSGGNQQKALLARWLMTNPRLLILD 439 N F+++ +R L ++TPS Q + LSGGNQQK ++A+WL + +L D Sbjct: 364 SLNFFLRRARMRRRASHFINLLAIRTPSAAQQVRLLSGGNQQKIVIAKWLERDCDVLFFD 423 Query: 440 EPTRGIDVGAKAEIYRLIAFLASEGMAVIMISSELPEVLGMSDRVMVMHEGELMGTLDRS 499 EPTRGIDVGAK+EIY+L+ LA EG A++MISSELPE+L MSDRV+VM EG + G L Sbjct: 424 EPTRGIDVGAKSEIYKLLRSLADEGKAIVMISSELPEILRMSDRVVVMCEGRITGELPAE 483 Query: 500 EATQEKVMQLAS 511 +ATQE++M LA+ Sbjct: 484 QATQERIMHLAT 495 Score = 101 bits (251), Expect = 7e-26 Identities = 61/225 (27%), Positives = 118/225 (52%), Gaps = 4/225 (1%) Query: 290 DVSFDLHAGEILGIAGLMGSGRTNVAETIFGITPSSSGQITLDGKAVRISDPHMAIEKGF 349 DV FDL GE+ + G G+G++ + + + G+ SG+I L G+ V + P A G Sbjct: 22 DVQFDLVEGEVHALMGENGAGKSTLMKILAGVYTRDSGEILLGGQPVELQSPRDAQAAGI 81 Query: 350 ALLTEDRKLSGLFPCLSVLENMEMAVLPHYTGNGFIQQKALRALCEDMCKKLRVKTPSLE 409 ++ ++ +L L+V +N+ + P F+ + L A ++ ++ V Sbjct: 82 GIIHQELQLMNH---LTVAQNIFIGREPRGRLGLFLDEDKLNAKAREILSRMHVNIDP-R 137 Query: 410 QCIDTLSGGNQQKALLARWLMTNPRLLILDEPTRGIDVGAKAEIYRLIAFLASEGMAVIM 469 + L+ +QQ +A+ L + R+LI+DEPT ++ AE++R+I L G+ V+ Sbjct: 138 AMVGNLTVASQQMVEIAKALSFDSRVLIMDEPTSALNDAEIAELFRIIRELKQRGVGVVY 197 Query: 470 ISSELPEVLGMSDRVMVMHEGELMGTLDRSEATQEKVMQLASGMT 514 IS ++ E+ ++DRV V+ +GE + T+ ++ + E ++ + G T Sbjct: 198 ISHKMDELKQIADRVTVLRDGEYVATVAAADTSVEAIIGMMVGRT 242 Score = 86.3 bits (212), Expect = 2e-21 Identities = 63/243 (25%), Positives = 110/243 (45%), Gaps = 10/243 (4%) Query: 24 LEIVNISKGFPGVVALADVQLRVRPGTVLALMGENGAGKSTLMKIIAGIYQPDAGEIRLR 83 LE+ N+ G + DV +R G +L G GAG++ + + + G ++GEI ++ Sbjct: 260 LEVRNLHAG----PLVRDVSFTLRKGEILGFAGLMGAGRTEVARAVFGADPVESGEIFVK 315 Query: 84 GKPIVFETPLAAQKAGIAMIHQE---LNLMPHMSIAENIWIG--REQLNSLHMVNHREMH 138 G TP A GI + ++ L M + NI + R L+ + M Sbjct: 316 GAKASIRTPSDAVAHGIGYLSEDRKRFGLATGMDVESNIVMSNLRNFLSLNFFLRRARMR 375 Query: 139 RCTAELLARLRINL-DPEEQVGNLSIAERQMVEIAKAVSYDSDILIMDEPTSAITEKEVA 197 R + + L I +QV LS +Q + IAK + D D+L DEPT I + Sbjct: 376 RRASHFINLLAIRTPSAAQQVRLLSGGNQQKIVIAKWLERDCDVLFFDEPTRGIDVGAKS 435 Query: 198 HLFSIIADLKSQGKGIVYITHKMNEVFAIADEVAVFRDGHYIGLQRADSMNSDSLISMMV 257 ++ ++ L +GK IV I+ ++ E+ ++D V V +G G A+ + ++ + Sbjct: 436 EIYKLLRSLADEGKAIVMISSELPEILRMSDRVVVMCEGRITGELPAEQATQERIMHLAT 495 Query: 258 GRE 260 R+ Sbjct: 496 QRQ 498 Lambda K H 0.320 0.136 0.381 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 569 Number of extensions: 23 Number of successful extensions: 8 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 3 Number of HSP's successfully gapped: 3 Length of query: 517 Length of database: 503 Length adjustment: 34 Effective length of query: 483 Effective length of database: 469 Effective search space: 226527 Effective search space used: 226527 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory