Align Monosaccharide-transporting ATPase, component of Glucose porter. Also bind xylose (Boucher and Noll 2011). Induced by glucose (Frock et al. 2012). Directly regulated by glucose-responsive regulator GluR (characterized)
to candidate H281DRAFT_00426 H281DRAFT_00426 monosaccharide ABC transporter ATP-binding protein, CUT2 family
Query= TCDB::G4FGN3 (494 letters) >FitnessBrowser__Burk376:H281DRAFT_00426 Length = 503 Score = 434 bits (1116), Expect = e-126 Identities = 230/495 (46%), Positives = 330/495 (66%), Gaps = 6/495 (1%) Query: 1 MKPILEVKSIHKRFPGVHALKGVSMEFYPGEVHAIVGENGAGKSTLMKIIAGVYQPDEGE 60 M P++ VK + K FPGV AL V + GEVHA++GENGAGKSTLMKI+AGVY D GE Sbjct: 1 MTPLISVKKLSKSFPGVRALHDVQFDLVEGEVHALMGENGAGKSTLMKILAGVYTRDSGE 60 Query: 61 IIYEGRGVRWNHPSEAINAGIVTVFQELSVMDNLSVAENIFMGDEEKR--GIFIDYKKMY 118 I+ G+ V P +A AGI + QEL +M++L+VA+NIF+G E + G+F+D K+ Sbjct: 61 ILLGGQPVELQSPRDAQAAGIGIIHQELQLMNHLTVAQNIFIGREPRGRLGLFLDEDKLN 120 Query: 119 REAEKFMKEEFGIEIDPEEKLGKYSIAIQQMVEIARAVYKKAKVLILDEPTSSLTQKETE 178 +A + + + IDP +G ++A QQMVEIA+A+ ++VLI+DEPTS+L E Sbjct: 121 AKAREILSR-MHVNIDPRAMVGNLTVASQQMVEIAKALSFDSRVLIMDEPTSALNDAEIA 179 Query: 179 KLFEVVKSLKEKGVAIIFISHRLEEIFEICDKVSVLRDGEYIGTDSIENLTKEKIVEMMV 238 +LF +++ LK++GV +++ISH+++E+ +I D+V+VLRDGEY+ T + + + E I+ MMV Sbjct: 180 ELFRIIRELKQRGVGVVYISHKMDELKQIADRVTVLRDGEYVATVAAADTSVEAIIGMMV 239 Query: 239 GRKLEKFY-IKEAHEPGEVVLEVKNL-SGERFENVSFSLRRGEILGFAGLVGAGRTELME 296 GR L A GE+ LEV+NL +G +VSF+LR+GEILGFAGL+GAGRTE+ Sbjct: 240 GRTLSDVAPAGRAASQGEIALEVRNLHAGPLVRDVSFTLRKGEILGFAGLMGAGRTEVAR 299 Query: 297 TIFGFRPKRGGEIYIEGKRVEINHPLDAIEQGIGLVPEDRKKLGLILIMSIMHNVSLPSL 356 +FG P GEI+++G + I P DA+ GIG + EDRK+ GL M + N+ + +L Sbjct: 300 AVFGADPVESGEIFVKGAKASIRTPSDAVAHGIGYLSEDRKRFGLATGMDVESNIVMSNL 359 Query: 357 DR-IKKGPFISFKREKELADWAIKTFDIRPAYPDRKVLYLSGGNQQKVVLAKWLALKPKI 415 + F+ R + A I IR ++V LSGGNQQK+V+AKWL + Sbjct: 360 RNFLSLNFFLRRARMRRRASHFINLLAIRTPSAAQQVRLLSGGNQQKIVIAKWLERDCDV 419 Query: 416 LILDEPTRGIDVGAKAEIYRIMSQLAKEGVGVIMISSELPEVLQMSDRIAVMSFGKLAGI 475 L DEPTRGIDVGAK+EIY+++ LA EG ++MISSELPE+L+MSDR+ VM G++ G Sbjct: 420 LFFDEPTRGIDVGAKSEIYKLLRSLADEGKAIVMISSELPEILRMSDRVVVMCEGRITGE 479 Query: 476 IDAKEASQEKVMKLA 490 + A++A+QE++M LA Sbjct: 480 LPAEQATQERIMHLA 494 Score = 108 bits (270), Expect = 4e-28 Identities = 70/233 (30%), Positives = 124/233 (53%), Gaps = 5/233 (2%) Query: 261 KNLSGER-FENVSFSLRRGEILGFAGLVGAGRTELMETIFGFRPKRGGEIYIEGKRVEIN 319 K+ G R +V F L GE+ G GAG++ LM+ + G + GEI + G+ VE+ Sbjct: 12 KSFPGVRALHDVQFDLVEGEVHALMGENGAGKSTLMKILAGVYTRDSGEILLGGQPVELQ 71 Query: 320 HPLDAIEQGIGLVPEDRKKLGLILIMSIMHNVSLPSLDRIKKGPFISFKREKELADWAIK 379 P DA GIG++ ++ L L+ +++ N+ + R + G F+ + A + Sbjct: 72 SPRDAQAAGIGIIHQE---LQLMNHLTVAQNIFIGREPRGRLGLFLDEDKLNAKAREILS 128 Query: 380 TFDIRPAYPDRKVLYLSGGNQQKVVLAKWLALKPKILILDEPTRGIDVGAKAEIYRIMSQ 439 + P V L+ +QQ V +AK L+ ++LI+DEPT ++ AE++RI+ + Sbjct: 129 RMHVN-IDPRAMVGNLTVASQQMVEIAKALSFDSRVLIMDEPTSALNDAEIAELFRIIRE 187 Query: 440 LAKEGVGVIMISSELPEVLQMSDRIAVMSFGKLAGIIDAKEASQEKVMKLAAG 492 L + GVGV+ IS ++ E+ Q++DR+ V+ G+ + A + S E ++ + G Sbjct: 188 LKQRGVGVVYISHKMDELKQIADRVTVLRDGEYVATVAAADTSVEAIIGMMVG 240 Score = 84.3 bits (207), Expect = 9e-21 Identities = 63/246 (25%), Positives = 114/246 (46%), Gaps = 10/246 (4%) Query: 5 LEVKSIHKRFPGVHALKGVSMEFYPGEVHAIVGENGAGKSTLMKIIAGVYQPDEGEIIYE 64 LEV+++H ++ VS GE+ G GAG++ + + + G + GEI + Sbjct: 260 LEVRNLHAG----PLVRDVSFTLRKGEILGFAGLMGAGRTEVARAVFGADPVESGEIFVK 315 Query: 65 GRGVRWNHPSEAINAGIVTVFQE---LSVMDNLSVAENIFMGDEEK---RGIFIDYKKMY 118 G PS+A+ GI + ++ + + V NI M + F+ +M Sbjct: 316 GAKASIRTPSDAVAHGIGYLSEDRKRFGLATGMDVESNIVMSNLRNFLSLNFFLRRARMR 375 Query: 119 REAEKFMKEEFGIEIDPEEKLGKYSIAIQQMVEIARAVYKKAKVLILDEPTSSLTQKETE 178 R A F+ +++ S QQ + IA+ + + VL DEPT + Sbjct: 376 RRASHFINLLAIRTPSAAQQVRLLSGGNQQKIVIAKWLERDCDVLFFDEPTRGIDVGAKS 435 Query: 179 KLFEVVKSLKEKGVAIIFISHRLEEIFEICDKVSVLRDGEYIGTDSIENLTKEKIVEMMV 238 +++++++SL ++G AI+ IS L EI + D+V V+ +G G E T+E+I+ + Sbjct: 436 EIYKLLRSLADEGKAIVMISSELPEILRMSDRVVVMCEGRITGELPAEQATQERIMHLAT 495 Query: 239 GRKLEK 244 R+ K Sbjct: 496 QRQTLK 501 Lambda K H 0.318 0.138 0.385 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 632 Number of extensions: 35 Number of successful extensions: 8 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 3 Number of HSP's successfully gapped: 3 Length of query: 494 Length of database: 503 Length adjustment: 34 Effective length of query: 460 Effective length of database: 469 Effective search space: 215740 Effective search space used: 215740 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory