Align Ribose import ATP-binding protein RbsA 1; EC 7.5.2.7 (characterized, see rationale)
to candidate H281DRAFT_00426 H281DRAFT_00426 monosaccharide ABC transporter ATP-binding protein, CUT2 family
Query= uniprot:Q9WXX0 (520 letters) >FitnessBrowser__Burk376:H281DRAFT_00426 Length = 503 Score = 455 bits (1171), Expect = e-132 Identities = 245/498 (49%), Positives = 336/498 (67%), Gaps = 7/498 (1%) Query: 14 ILKAKGIVKRFPGVVAVDNVDFEVYENEIVSLIGENGAGKSTLIKILTGVLKPDAGEILV 73 ++ K + K FPGV A+ +V F++ E E+ +L+GENGAGKSTL+KIL GV D+GEIL+ Sbjct: 4 LISVKKLSKSFPGVRALHDVQFDLVEGEVHALMGENGAGKSTLMKILAGVYTRDSGEILL 63 Query: 74 NGERVEFHSPVDAFKKGISVIHQELNLCDNMTVAENIFLAYEAVRGQKRTLSSRVDENYM 133 G+ VE SP DA GI +IHQEL L +++TVA+NIF+ E RG+ L +DE+ + Sbjct: 64 GGQPVELQSPRDAQAAGIGIIHQELQLMNHLTVAQNIFIGREP-RGR---LGLFLDEDKL 119 Query: 134 YTRSKELLDLIGAKFSPDALVRNLTTAQRQMVEICKALVKEPRIIFMDEPTSSLTVEETE 193 +++E+L + P A+V NLT A +QMVEI KAL + R++ MDEPTS+L E Sbjct: 120 NAKAREILSRMHVNIDPRAMVGNLTVASQQMVEIAKALSFDSRVLIMDEPTSALNDAEIA 179 Query: 194 RLFEIIEMLKSRGISVVFVSHRLDEVMRISDRIVVMRDGKRIGELKKGEFDVDTIIKMMV 253 LF II LK RG+ VV++SH++DE+ +I+DR+ V+RDG+ + + + V+ II MMV Sbjct: 180 ELFRIIRELKQRGVGVVYISHKMDELKQIADRVTVLRDGEYVATVAAADTSVEAIIGMMV 239 Query: 254 GREV-EFFPHGIETRPGEIALEVRNLKWKDKVKNVSFEVRKGEVLGFAGLVGAGRTETML 312 GR + + P G GEIALEVRNL V++VSF +RKGE+LGFAGL+GAGRTE Sbjct: 240 GRTLSDVAPAGRAASQGEIALEVRNLHAGPLVRDVSFTLRKGEILGFAGLMGAGRTEVAR 299 Query: 313 LVFGVNQKESGDIYVNGRKVEIKNPEDAIKMGIGLIPEDRKLQGLVLRMTVKDNIVLPSL 372 VFG + ESG+I+V G K I+ P DA+ GIG + EDRK GL M V+ NIV+ +L Sbjct: 300 AVFGADPVESGEIFVKGAKASIRTPSDAVAHGIGYLSEDRKRFGLATGMDVESNIVMSNL 359 Query: 373 KKISRWGLVLDERKEEEISEDYVKRLSIKTPSIYQITENLSGGNQQKVVLAKWLATNADI 432 + L + + ++ L+I+TPS Q LSGGNQQK+V+AKWL + D+ Sbjct: 360 RNFLSLNFFLRRARMRRRASHFINLLAIRTPSAAQQVRLLSGGNQQKIVIAKWLERDCDV 419 Query: 433 LIFDEPTRGIDVGAKAEIHRMIRELAAQGKAVIMISSELPEILNLSDRIVVMWEGEITAV 492 L FDEPTRGIDVGAK+EI++++R LA +GKA++MISSELPEIL +SDR+VVM EG IT Sbjct: 420 LFFDEPTRGIDVGAKSEIYKLLRSLADEGKAIVMISSELPEILRMSDRVVVMCEGRITGE 479 Query: 493 LDNREKRVTQEEIMYYAS 510 L ++ TQE IM+ A+ Sbjct: 480 LP--AEQATQERIMHLAT 495 Score = 95.1 bits (235), Expect = 5e-24 Identities = 63/232 (27%), Positives = 117/232 (50%), Gaps = 9/232 (3%) Query: 30 VDNVDFEVYENEIVSLIGENGAGKSTLIKILTGVLKPDAGEILVNGERVEFHSPVDAFKK 89 V +V F + + EI+ G GAG++ + + + G ++GEI V G + +P DA Sbjct: 271 VRDVSFTLRKGEILGFAGLMGAGRTEVARAVFGADPVESGEIFVKGAKASIRTPSDAVAH 330 Query: 90 GISVIHQE---LNLCDNMTVAENIFLAYEAVRGQKRTLSSRVDENYMYTRSKELLDLIGA 146 GI + ++ L M V NI ++ +L+ + M R+ ++L+ Sbjct: 331 GIGYLSEDRKRFGLATGMDVESNIVMSNLR---NFLSLNFFLRRARMRRRASHFINLLAI 387 Query: 147 KFSPDAL--VRNLTTAQRQMVEICKALVKEPRIIFMDEPTSSLTVEETERLFEIIEMLKS 204 + +P A VR L+ +Q + I K L ++ ++F DEPT + V +++++ L Sbjct: 388 R-TPSAAQQVRLLSGGNQQKIVIAKWLERDCDVLFFDEPTRGIDVGAKSEIYKLLRSLAD 446 Query: 205 RGISVVFVSHRLDEVMRISDRIVVMRDGKRIGELKKGEFDVDTIIKMMVGRE 256 G ++V +S L E++R+SDR+VVM +G+ GEL + + I+ + R+ Sbjct: 447 EGKAIVMISSELPEILRMSDRVVVMCEGRITGELPAEQATQERIMHLATQRQ 498 Lambda K H 0.319 0.138 0.381 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 676 Number of extensions: 27 Number of successful extensions: 7 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 2 Number of HSP's successfully gapped: 2 Length of query: 520 Length of database: 503 Length adjustment: 35 Effective length of query: 485 Effective length of database: 468 Effective search space: 226980 Effective search space used: 226980 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory