GapMind for catabolism of small carbon sources

 

catabolism of small carbon sources in Caulobacter crescentus NA1000

Pathways are sorted by name. Sort by completeness instead.

Pathway Steps
acetate deh, acs
D-alanine cycA, dadA
alanine snatA
arabinose araE, xacB, xacC, xacD, xacE, xacF
arginine rocE, adiA, aguA, aguB, puuA, puuB, puuC, puuD, gabT, gabD
asparagine ans, glt
aspartate glt
cellobiose bgl, MFS-glucose, glk
citrate SLC13A5, acn, icd
citrulline AO353_03055, AO353_03050, AO353_03045, AO353_03040, citrullinase, odc, puuA, puuB, puuC, puuD, gabT, gabD
deoxyinosine nupC, deoD, deoB, deoC, adh, acs
deoxyribonate deoxyribonate-transport, deoxyribonate-dehyd, ketodeoxyribonate-cleavage, garK, atoA, atoD, atoB
deoxyribose deoP, deoK, deoC, adh, acs
ethanol etoh-dh-nad, adh, acs
fructose glcP, scrK
fucose fucP, fucU, fucI, fucK, fucA, tpi, aldA
fumarate dctA
galactose HP1174, galdh, galactonolactonase, dgoD, dgoK, dgoA
galacturonate exuT, uxaC, uxaB, uxaA, kdgK, eda
gluconate gntT, gntK, edd, eda
glucose MFS-glucose, glk
glucose-6-P uhpT
glucosamine nagX, nagF, nagEcb, nagA, nagB
glucuronate exuT, uxaC, uxuB, uxuA, kdgK, eda
glutamate gltP, gdhA
glycerol glpF, glpK, glpD, tpi
histidine PA5503, PA5504, PA5505, hutH, hutU, hutI, hutF, hutG'
isoleucine Bap2, ofo, acdH, ech, ivdG, fadA, pccA, pccB, epi, mcmA
4-hydroxybenzoate pcaK, pobA, pcaH, pcaG, pcaB, pcaC, pcaD, pcaI, pcaJ, pcaF
D-lactate lctP, D-LDH
L-lactate lctP, L-LDH
lactose lacA', lacC', lacB', klh, MFS-glucose, glk
leucine leuT, ilvE, ofo, liuA, liuB, liuD, liuC, liuE, atoA, atoD, atoB
lysine lysP, lat, amaB, lysN, hglS, ydiJ
L-malate dctA
maltose malI, susB, glk
mannitol PLT5, mt2d, scrK
mannose manP, manA
myoinositol iatP, iatA, ibpA, iolG, iolE, iolD, iolB, iolC, iolJ, mmsA, tpi
NAG nagF, nagEcb, nagA, nagB
2-oxoglutarate kgtP
phenylacetate paaT, paaK, paaA, paaB, paaC, paaE, paaG, paaZ1, paaZ2, paaJ1, paaF, paaH, paaJ2
phenylalanine aroP, PAH, PCBD, QDPR, HPD, hmgA, maiA, fahA, atoA, atoD, atoB
proline CCNA_00435, put1, putA
propionate putP, prpE, pccA, pccB, epi, mcmA
putrescine potA, potB, potC, potD, puuA, puuB, puuC, puuD, gabT, gabD
pyruvate SLC5A8
rhamnose rhaT, rhaM, rhaA, rhaB, rhaD, tpi, aldA
ribose rbsU, rbsK
D-serine cycA, dsdA
serine snatA, sdaB
sorbitol SOT, sdh, scrK
succinate dctA
sucrose scrT, ams, scrK, glk
threonine snatA, ltaE, adh, acs, gcvP, gcvT, gcvH, lpd
thymidine nupG, deoA, deoB, deoC, adh, acs
trehalose treF, MFS-glucose, glk
tryptophan aroP, tnaA
tyrosine aroP, HPD, hmgA, maiA, fahA, atoA, atoD, atoB
valine Bap2, ofo, acdH, ech, bch, mmsB, mmsA, pccA, pccB, epi, mcmA
xylitol fruI, x5p-reductase
xylose xylT, xdh, xylC, xad, kdaD, dopDH

Confidence: high confidence medium confidence low confidence
transporter – transporters and PTS systems are shaded because predicting their specificity is particularly challenging.

This GapMind analysis is from May 21 2021. The underlying query database was built on May 21 2021.

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About GapMind

Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer. Ublast hits may be split across two different proteins.

A candidate for a step is "high confidence" if either:

where "other" refers to the best ublast hit to a sequence that is not annotated as performing this step (and is not "ignored").

Otherwise, a candidate is "medium confidence" if either:

Other blast hits with at least 50% coverage are "low confidence."

Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. Gaps may be due to:

GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).

For more information, see the paper from 2019 on GapMind for amino acid biosynthesis, or view the source code.

If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know

by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory