Align Glucosamine-6-phosphate deaminase [isomerizing], alternative (EC 3.5.99.6) (characterized)
to candidate CCNA_00569 CCNA_00569 glucosamine-6-phosphate deaminase
Query= reanno::Caulo:CCNA_00453 (363 letters) >FitnessBrowser__Caulo:CCNA_00569 Length = 358 Score = 560 bits (1443), Expect = e-164 Identities = 297/363 (81%), Positives = 314/363 (86%), Gaps = 5/363 (1%) Query: 1 MEATVLTRHETPAPTGASPPSLAPASTHMFREAGEAARVAAVQLTANAPKIQALAQRLRA 60 MEATVLTR P GA+P L+P T MF EAGE A V L ANA ++ ALA+RLRA Sbjct: 1 MEATVLTR-----PEGAAPARLSPEDTRMFLEAGEGAAVVRTLLAANAERVAALAERLRA 55 Query: 61 NPPRVVVTCARGSSDHAATFARYLIETKAGVLTSSAGPSVSSVYDASPNLEGALYLAISQ 120 +PPRVVVTCARGSSDHAATFARYLIETKAGVLTSSAG SVSSVYDASPNLEGAL LA+SQ Sbjct: 56 HPPRVVVTCARGSSDHAATFARYLIETKAGVLTSSAGLSVSSVYDASPNLEGALCLAVSQ 115 Query: 121 SGKSPDLLAAVKAAKAAGAHAVALVNVVDSPLAALADEVIPLHAGPELSVAATKSYIAAL 180 SGKSPDLLA+VKAAKAAGAHAVA VNV DSPLAALAD VIPLHAGPELSVAATKSYIAAL Sbjct: 116 SGKSPDLLASVKAAKAAGAHAVAFVNVEDSPLAALADVVIPLHAGPELSVAATKSYIAAL 175 Query: 181 VAVTQLIAAWTEDAELTAALQDLPTALAAAWTLDWSLAVERLKTASNLYVLGRGVGFGVA 240 A+TQLIAAWT+D LTAAL+ LP L AAW LDWS AVE L+ A NLYVLGRGVGFGVA Sbjct: 176 AAITQLIAAWTQDEALTAALEGLPLQLEAAWNLDWSSAVEGLRHAINLYVLGRGVGFGVA 235 Query: 241 LEAALKFKETCGLHAEAFSAAEVLHGPMALVKDGFPALVFAQNDESRASVDEMAAGLRAR 300 LEAALKFKETCGLHAEAFSAAEVLHGPMALVK+GFPALVFAQNDESR SV EMA GLR R Sbjct: 236 LEAALKFKETCGLHAEAFSAAEVLHGPMALVKEGFPALVFAQNDESRESVVEMAQGLRQR 295 Query: 301 GASVLIAGGGGDAPDALPTLASHPVLEPILMIQSFYRMANALSVARGYDPDSPPHLNKVT 360 GASVL+A G DAP LPT SHPVLEPILM+QSFYRMANALSVARGY+PDSPPHLNKVT Sbjct: 296 GASVLMAAPGDDAPGGLPTPLSHPVLEPILMVQSFYRMANALSVARGYNPDSPPHLNKVT 355 Query: 361 ETI 363 ET+ Sbjct: 356 ETL 358 Lambda K H 0.315 0.128 0.360 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 502 Number of extensions: 10 Number of successful extensions: 2 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 363 Length of database: 358 Length adjustment: 29 Effective length of query: 334 Effective length of database: 329 Effective search space: 109886 Effective search space used: 109886 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 49 (23.5 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory