Align m-Inositol ABC transporter, ATPase component (itaA) (characterized)
to candidate CCNA_00903 CCNA_00903 inositol transport ATP-binding protein IatA
Query= reanno::pseudo3_N2E3:AO353_21385 (521 letters) >FitnessBrowser__Caulo:CCNA_00903 Length = 515 Score = 373 bits (957), Expect = e-107 Identities = 208/494 (42%), Positives = 309/494 (62%), Gaps = 10/494 (2%) Query: 27 LLEIINVSKGFPGVVALSDVQLRVRPGSVLALMGENGAGKSTLMKIIAGIYQPDAGELRL 86 LL++ VSK FPGV AL V L V G V AL+GENGAGKSTL+KI++ + DAG + Sbjct: 3 LLDVSQVSKSFPGVRALDQVDLVVGVGEVHALLGENGAGKSTLIKILSAAHAADAGTVTF 62 Query: 87 RGKPVT-FDTPLAALQAGIAMIHQELNLMPHMSIAENIWIGREQLNGFHMIDHREMHRCT 145 G+ + D PL Q GIA I+QE NL P +S+AEN+++GRE ++D + Sbjct: 63 AGQVLDPRDAPLRRQQLGIATIYQEFNLFPELSVAENMYLGREPRR-LGLVDWSRLRADA 121 Query: 146 AQLLERLRINLDPEEQVGNLSIAERQMVEIAKAVSYDSDILIMDEPTSAITDKEVAHLFS 205 LL L + L+P+ V L++AE+QMVEIAKA++ ++ ++IMDEPT+A++ +EV L + Sbjct: 122 QALLNDLGLPLNPDAPVRGLTVAEQQMVEIAKAMTLNARLIIMDEPTAALSGREVDRLHA 181 Query: 206 IIADLKAQGKGIIYITHKMNEVFSIADEVAVFRDGAYIGLQRADSMDGDSLISMMVGREL 265 IIA LKA+ +IY++H++ EV ++ D V RDG ++ ++ ++ +MVGR + Sbjct: 182 IIAGLKARSVSVIYVSHRLGEVKAMCDRYTVMRDGRFVASGDVADVEVADMVRLMVGRHV 241 Query: 266 SQLFPVREKPIGDLLMSVRD-------LRLDGVFKGVSFDLHAGEILGIAGLMGSGRTNV 318 R +P G +++ V L G + VSF GEI+G+AGL+G+GRT++ Sbjct: 242 EFERRKRRRPPGAVVLKVEGVTPAAPRLSAPGYLRQVSFAARGGEIVGLAGLVGAGRTDL 301 Query: 319 AEAIFGITPSDGGEICLDGQPVRISDPHMAIEKGFALLTEDRKLSGLFPCLSVLENMEMA 378 A IFG P G + +D +P+R+ P AI+ G L+ EDRK G F S+ N+ + Sbjct: 302 ARLIFGADPIAAGRVLVDDKPLRLRSPRDAIQAGIMLVPEDRKQQGCFLDHSIRRNLSLP 361 Query: 379 VLPHYAGNG-FIQQKALRALCEDMCKKLRVKTPSLEQCIDTLSGGNQQKALLARWLMTNP 437 L + G ++ ++A R L E +KLR+K E I LSGGNQQK LL R + P Sbjct: 362 SLKALSALGQWVDERAERDLVETYRQKLRIKMADAETAIGKLSGGNQQKVLLGRAMALTP 421 Query: 438 RILILDEPTRGIDVGAKAEIYRLISYLASEGMAVIMISSELPEVLGMSDRVMVMHEGDLM 497 ++LI+DEPTRGID+GAKAE+++++S LA G+AV++ISSEL EV+ +SDR++V EG ++ Sbjct: 422 KVLIVDEPTRGIDIGAKAEVHQVLSDLADLGVAVVVISSELAEVMAVSDRIVVFREGVIV 481 Query: 498 GTLDRSEATQERVM 511 LD AT+E +M Sbjct: 482 ADLDAQTATEEGLM 495 Score = 91.3 bits (225), Expect = 8e-23 Identities = 66/244 (27%), Positives = 122/244 (50%), Gaps = 11/244 (4%) Query: 27 LLEIINVSKGFPGVVA---LSDVQLRVRPGSVLALMGENGAGKSTLMKIIAGIYQPDAGE 83 +L++ V+ P + A L V R G ++ L G GAG++ L ++I G AG Sbjct: 256 VLKVEGVTPAAPRLSAPGYLRQVSFAARGGEIVGLAGLVGAGRTDLARLIFGADPIAAGR 315 Query: 84 LRLRGKPVTFDTPLAALQAGIAMIHQELN----LMPHMSIAENIWI-GREQLNGF-HMID 137 + + KP+ +P A+QAGI ++ ++ + H SI N+ + + L+ +D Sbjct: 316 VLVDDKPLRLRSPRDAIQAGIMLVPEDRKQQGCFLDH-SIRRNLSLPSLKALSALGQWVD 374 Query: 138 HREMHRCTAQLLERLRINL-DPEEQVGNLSIAERQMVEIAKAVSYDSDILIMDEPTSAIT 196 R ++LRI + D E +G LS +Q V + +A++ +LI+DEPT I Sbjct: 375 ERAERDLVETYRQKLRIKMADAETAIGKLSGGNQQKVLLGRAMALTPKVLIVDEPTRGID 434 Query: 197 DKEVAHLFSIIADLKAQGKGIIYITHKMNEVFSIADEVAVFRDGAYIGLQRADSMDGDSL 256 A + +++DL G ++ I+ ++ EV +++D + VFR+G + A + + L Sbjct: 435 IGAKAEVHQVLSDLADLGVAVVVISSELAEVMAVSDRIVVFREGVIVADLDAQTATEEGL 494 Query: 257 ISMM 260 ++ M Sbjct: 495 MAYM 498 Score = 72.4 bits (176), Expect = 4e-17 Identities = 60/223 (26%), Positives = 103/223 (46%), Gaps = 15/223 (6%) Query: 302 GEILGIAGLMGSGRTNVAEAIFGITPSDGGEICLDGQPVRISD-PHMAIEKGFALLTEDR 360 GE+ + G G+G++ + + + +D G + GQ + D P + G A + ++ Sbjct: 29 GEVHALLGENGAGKSTLIKILSAAHAADAGTVTFAGQVLDPRDAPLRRQQLGIATIYQE- 87 Query: 361 KLSGLFPCLSVLENMEMAVLPHYAGNGFIQQKALRA----LCEDMCKKLRVKTPSLEQCI 416 LFP LSV ENM + P G + LRA L D+ L P + Sbjct: 88 --FNLFPELSVAENMYLGREPRRLG--LVDWSRLRADAQALLNDLGLPLNPDAP-----V 138 Query: 417 DTLSGGNQQKALLARWLMTNPRILILDEPTRGIDVGAKAEIYRLISYLASEGMAVIMISS 476 L+ QQ +A+ + N R++I+DEPT + ++ +I+ L + ++VI +S Sbjct: 139 RGLTVAEQQMVEIAKAMTLNARLIIMDEPTAALSGREVDRLHAIIAGLKARSVSVIYVSH 198 Query: 477 ELPEVLGMSDRVMVMHEGDLMGTLDRSEATQERVMQLASGMSV 519 L EV M DR VM +G + + D ++ +++L G V Sbjct: 199 RLGEVKAMCDRYTVMRDGRFVASGDVADVEVADMVRLMVGRHV 241 Lambda K H 0.321 0.137 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 676 Number of extensions: 37 Number of successful extensions: 10 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 3 Number of HSP's successfully gapped: 3 Length of query: 521 Length of database: 515 Length adjustment: 35 Effective length of query: 486 Effective length of database: 480 Effective search space: 233280 Effective search space used: 233280 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory