Align sodium/glucose cotransporter 1 (characterized)
to candidate Echvi_1871 Echvi_1871 transporter, SSS family
Query= CharProtDB::CH_091086 (664 letters) >FitnessBrowser__Cola:Echvi_1871 Length = 547 Score = 257 bits (656), Expect = 1e-72 Identities = 172/523 (32%), Positives = 282/523 (53%), Gaps = 34/523 (6%) Query: 25 NAADISIIVIYFVVVMAVGLWAMFSTNRGTVGG---FFLAGRSMVWWPIGASLFASNIGS 81 N D+ + V Y ++++ +G+ + +G V +FLA +++ WW +GASL ASNI + Sbjct: 4 NTLDLVVFVAYCLLIITMGI-VVSREKKGHVKDSKDYFLASKALPWWAVGASLIASNISA 62 Query: 82 GHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRI 141 F+G++G+G A G+AI +EW A ++V+ F+PIY+K G+ TMP++L +R+ G R+ Sbjct: 63 EQFIGMSGSGFALGLAISTYEWMAAATLLVVAIFFLPIYLKEGIYTMPQFLNRRYDG-RV 121 Query: 142 QVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVI 201 + +++ LL+Y+F +++ ++ GA+ + +G+ L I L +Y+I GGL AV Sbjct: 122 RTVMAIFWLLIYVFVNLTSVLYLGALSLETIMGVPLTYGIIGLALFAMVYSIYGGLKAVA 181 Query: 202 YTDTLQTVIMLVGSLILTGFAFHEVGGYDAF--MEKYMKAIPTIVSDGNTTFQEKCYTPR 259 +TD +Q V ++ G L T A VG D + + KA P+ S EK Sbjct: 182 WTDVVQVVFLVAGGLATTYLALSLVGDGDVWEGIGILRKAAPSHFS----MIIEKGEMMI 237 Query: 260 ADSFHIFRDPLTGDLPWPG-FIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCG 318 D RD DLP I GM I+ L YW +Q I QR L+AK++ + G + G Sbjct: 238 PDGSGGSRDAYL-DLPGLSVLIGGMWIVNLNYWGCNQYITQRALAAKSLGEAQTGMVFAG 296 Query: 319 YLKLMPMFIMVMPGMISRILYTEKI-ACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNG 377 +LKL+ I+V+PG+ + ++ + A + S + G + ++ AYPTL + L+P G Sbjct: 297 FLKLLMPLIVVIPGIAAYVIVQKGADASFIESMTDPVTG--LAKSDRAYPTL-LHLLPPG 353 Query: 378 LRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAK-VRKRASEKELMIAGRLFILVLIGI 436 L+GL + + A+++SSL S+ NS ST+FT+DIY + K SE + + GR I ++ Sbjct: 354 LKGLAFAALTAAIVSSLASMANSTSTIFTIDIYKEFFNKNVSEGKQVTIGR--ITAVVAF 411 Query: 437 SIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGL-LI 495 IA + Q Q Q F YIQ T ++ P + A+F+ FWK+ A +L + L Sbjct: 412 IIAAIVAPQLRQLDQAFQYIQEYTGFVSPGVFAIFIFGFFWKKTTSNAALTAAVLTIPLS 471 Query: 496 GISRMITEFAYGTGSCMEPSNCPTI-ICGVHYLYFAIILFAIS 537 ++IT N P I GV +L ++++ AIS Sbjct: 472 AAFKVIT------------PNLPFIDRMGVVFLVLSVLIIAIS 502 Lambda K H 0.327 0.141 0.436 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 710 Number of extensions: 29 Number of successful extensions: 5 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 664 Length of database: 547 Length adjustment: 37 Effective length of query: 627 Effective length of database: 510 Effective search space: 319770 Effective search space used: 319770 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.7 bits) S2: 53 (25.0 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory