Align Aspartate-proton symporter; L-aspartate transporter (characterized)
to candidate RR42_RS36375 RR42_RS36375 aspartate:proton symporter
Query= SwissProt::O07002 (520 letters) >FitnessBrowser__Cup4G11:RR42_RS36375 Length = 524 Score = 671 bits (1731), Expect = 0.0 Identities = 306/514 (59%), Positives = 411/514 (79%), Gaps = 1/514 (0%) Query: 4 QGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSGAFSWILGGAIILLIGLVYA 63 QG F++ +SL DL IG+GAIFGS WLFA S+V++ AGP+G SW+LGG +LL+G+VY Sbjct: 5 QGKFKRQLSLTDLTFIGLGAIFGSGWLFAASHVSAIAGPAGIISWLLGGFAVLLLGIVYC 64 Query: 64 ELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSLISIEVTAVRQYVAYWFPGLTI 123 ELGAALPR GGIIRYPV+SHG L+GYL+ +T++A++SLI+IEV A RQY A WFP L+ Sbjct: 65 ELGAALPRAGGIIRYPVFSHGELMGYLMGLITLIAFSSLIAIEVVAARQYAAAWFPFLSQ 124 Query: 124 KGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANFIISIFKYIVPITIIIVLIFHFQP 183 GS +PT+ GW LQFA+LCLFF+LNY+SVKTFA+AN I+S+FK++VP+ +I+VL HF+P Sbjct: 125 PGSSNPTLPGWALQFAMLCLFFVLNYYSVKTFARANNIVSVFKFVVPLLVIVVLFTHFKP 184 Query: 184 ENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPIVSVAGEVQNPKRNIPIALIICIIVS 243 NL V GFAPFG +GIQAA+S GG++FAYLGL PI+SVA EV++P+R IPIALI+ +++S Sbjct: 185 ANLQVHGFAPFGLSGIQAAVSAGGIIFAYLGLTPIISVASEVRSPQRTIPIALILSVLLS 244 Query: 244 TIIYTVLQVTFIGAIPTETLKHGWPAIGREFSLPFKDIAVMLGLGWLATLVILDAILSPG 303 T+IY +LQ+ F+G +PTETL GW +G+ F+LP++DIA+ LG+GWLA LV+ DA++SP Sbjct: 245 TLIYVLLQIAFLGGVPTETLSDGWRGVGQAFALPYRDIALALGVGWLAFLVVSDAVISPS 304 Query: 304 GNGNIFMNTTSRLVYAWARNGTLFGIFSKVNKDTGTPRASLWLSFALSIFWTLPFPSWNA 363 G GNI+MN T R+VY WAR GT F FS+++ +G PR +LWL+FALS+FWTLPFPSW A Sbjct: 305 GTGNIYMNATPRVVYGWARGGTFFKSFSRIDAASGIPRPALWLTFALSVFWTLPFPSWEA 364 Query: 364 LVNVCSVALILSYAIAPISSAALRVNAKDLNRPFYLKGMSIIGPLSFIFTAFIVYWSGWK 423 ++NV S AL+LSYA+AP++ AALR NA L+RPF ++ ++++GPLSFI A IVYWSGW Sbjct: 365 MINVVSAALVLSYAVAPVTVAALRRNAPSLHRPFRVRWLAVLGPLSFIIAALIVYWSGWG 424 Query: 424 TVSWLLGSQLVMFLIYLCFSKYTPKEDVSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGL 483 TVSWLLG Q+ MF++YL + P +SLAQQ+KS+ WLI FY+++++ SY+G+FG G+ Sbjct: 425 TVSWLLGLQIAMFVVYLLCRRAVPTHRLSLAQQVKSSLWLIAFYLLIIVASYLGTFG-GI 483 Query: 484 GIISNPVDLILVAIGSLAIYYWAKYTGLPKAAID 517 G IS+P D LVA+ +L IY W TG+P A +D Sbjct: 484 GAISHPWDTGLVALIALGIYGWGARTGIPAALLD 517 Lambda K H 0.328 0.143 0.451 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 1018 Number of extensions: 45 Number of successful extensions: 3 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 520 Length of database: 524 Length adjustment: 35 Effective length of query: 485 Effective length of database: 489 Effective search space: 237165 Effective search space used: 237165 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.7 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory