Align 2-deoxy-D-ribose dehydrogenase β subunit (characterized)
to candidate RR42_RS09125 RR42_RS09125 acylaldehyde oxidase
Query= metacyc::MONOMER-20833 (739 letters) >FitnessBrowser__Cup4G11:RR42_RS09125 Length = 755 Score = 397 bits (1021), Expect = e-115 Identities = 272/773 (35%), Positives = 396/773 (51%), Gaps = 74/773 (9%) Query: 14 LSRRRFLASTAVGALVIGFGLPLGAGRVQAATSAER---GTQVP--AFLEIRPDGTVRLL 68 + RR FL + GA + G + R + ATS GTQV ++++ D TV ++ Sbjct: 1 MKRRAFLVAGIGGAGALLVGWSVLPPRQRLATSQPLPAVGTQVGLNGWVKVAADNTVTIM 60 Query: 69 SPFMEGGQGTHTAMAQIVGEELDADPATFIVEAAPPGEAY----VVMEN----------- 113 E GQG HT +A ++ +ELDA+ A VE AP + Y VV+E+ Sbjct: 61 MCRSEMGQGVHTGLAMVLADELDANWAQVKVEHAPVDKIYNNLEVVVEDLPFRADDDGVA 120 Query: 114 ---------------GLRITGGSMSVRMSYPTMRRLGALARAMLLQAGAKQWGVPVGELT 158 G +TGGS S+ + MR GA ARAML+ A A +W VP G Sbjct: 121 RHLAAWLTRKLMREIGEMVTGGSSSLNDLWNPMREAGASARAMLIGAAAARWNVPAGACR 180 Query: 159 TQPGRVVHAASGRSLGYGELASSALDMPVPDPASITLRDPSQFRWIGKPVKRLDAYDKST 218 Q G+V+H SG++ +GELA+ A +P+ PA + L+ PS+F+ IGK ++R++A K Sbjct: 181 AQDGKVLH-PSGKTATFGELAAQAGQLPL--PAKVALKTPSEFKLIGKDIRRIEAASKID 237 Query: 219 GKALYSIDLKVDNMLHAAVQHAPRLGMTVGSLRNQSQVEGMKGVHSVHVL------PGAV 272 G A + ID+ + +L+A+V P LG TV S + + M G+ V + G V Sbjct: 238 GTARFGIDVLPEGLLYASVTMCPTLGGTVASF-DGAVAAAMPGIVKVLAVDAYNGGTGGV 296 Query: 273 AVVAERWWHAKRAVEAIQVDWQEAAADS------ALRVMPADFSSDKHREFLAAQQGPTR 326 AV+A+ + A +A++A+++ W AA S + R+ A +SD H + Sbjct: 297 AVIADNAYRAMKALDAVKIVWNPGAAASLSSPEVSRRLAQALDASDGHAYY--------- 347 Query: 327 DDENEGDVAGALKGAKTQVEATYHNQYLNHAQLEPPSALARFNPDGTLEIWLPNQAPDMF 386 GDV ALK A V A Y YL H +EP + + DG +W+ Q P + Sbjct: 348 ---RHGDVDAALKSAAKPVSAEYSAPYLAHGAVEPINCTVQVR-DGAARVWVSTQLPGLA 403 Query: 387 RADIAKRTGLDPAQITLHSPLLGGFFGRHFLYDSANPYPQAIALAKA-VSRPIKLIWSRE 445 R ++K G+D ++ + L+GG FGR D + QA A+A+A RP++ IWSR Sbjct: 404 RRAVSKVLGIDADKVDVQPQLIGGAFGRRLEVDFIS---QAAAIARAGGGRPVQTIWSRV 460 Query: 446 EEFLRDVLRPLAVVKFRAALDDKGLPVAIEAVSATEGPTEA----LAGKQGDKIDPTAVE 501 ++ D RP + +F+A LD G VA SA++ A L G G ID T E Sbjct: 461 QDTTHDFYRPACLSRFKAGLDGAGNLVAWHNTSASQAVVPAMLARLLGLPGLGIDKTTTE 520 Query: 502 GLSGKSYAIPNKRIAQIYVKGAPMLGYWRSVGNSLNDFFYESFLDELADKGGHDPYELRL 561 G + Y PN R+ + V +G+WRSVG+S FF ESF+DELA G DP R Sbjct: 521 GAFDRPYEWPNARVGHVIVDLPVPVGFWRSVGHSHQAFFTESFIDELAAAAGKDPVAFRA 580 Query: 562 HLLRDNPRLTTLLQAAGELSGGWKRGPFTAEDGTRRARGVAMASPFGSHTAAIAEVSIEN 621 LL +PR +L A + GW + DG RARGVA+ +GS A +AEVS+ Sbjct: 581 GLLARHPRHLAVLHMAAD-KAGWAKPLGKTADGAARARGVALHEAYGSIVAQVAEVSVAP 639 Query: 622 GK-VKVHDIWQAIDPGSIVNPAIVEAQVNGAVALGLSQTLLEEAVYVDGKPRARNYDLYP 680 K V+VH + AID G VNP ++ Q+ A+ GLS L EE VDG+ + + +P Sbjct: 640 DKTVRVHRVVCAIDCGLPVNPNLIRQQMESAIIFGLSAALFEEITIVDGQVHQKTFGDFP 699 Query: 681 ILAPAQMARVHVRVVESGEKMGGIGEPPLPAVAPAVANAVAQLTGQRVRSLPL 733 ++ + ++ S + G+GEP P +APAVANA+ LTGQR+R+LPL Sbjct: 700 VIFMNNCPAIETYIMPSQDHPQGVGEPGTPPIAPAVANALFALTGQRLRALPL 752 Lambda K H 0.317 0.134 0.394 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 1355 Number of extensions: 78 Number of successful extensions: 11 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 2 Number of HSP's successfully gapped: 1 Length of query: 739 Length of database: 755 Length adjustment: 40 Effective length of query: 699 Effective length of database: 715 Effective search space: 499785 Effective search space used: 499785 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 55 (25.8 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory