Align Ribose import ATP-binding protein RbsA; EC 7.5.2.7 (characterized, see rationale)
to candidate RR42_RS04800 RR42_RS04800 ABC transporter
Query= uniprot:D8IZC7 (521 letters) >FitnessBrowser__Cup4G11:RR42_RS04800 Length = 529 Score = 279 bits (714), Expect = 2e-79 Identities = 173/507 (34%), Positives = 283/507 (55%), Gaps = 19/507 (3%) Query: 1 MTQTPLLQMRGIRKSFGATLALSDMHLTIRPGEIHALMGENGAGKSTLMKVLSGVHAPDQ 60 ++ TP L + I K + A D+ L + PGEIHA++GENGAGKSTLMK++ G PD Sbjct: 3 LSTTPRLALAHISKRYPGVTANDDVSLVVAPGEIHAVLGENGAGKSTLMKIIFGAVKPDA 62 Query: 61 GEILLDGRPVALRDPGASRAAGINLIYQELAVAPNISVAANVFMGSEL--RTRLGLIDHA 118 G++ +G A+ +P +R GI +++Q ++ ++VA N+ +G +T G Sbjct: 63 GDMHFNGARAAIHNPHDARNLGIAMVFQHFSLFDTLTVAENIALGLPRGSKTAAGSPHAG 122 Query: 119 AMRSRTDAVLRQLGAGFGASDLAGR----LSIAEQQQVEIARALVHRSRIVIMDEPTAAL 174 + +R+ +G R LS+ E+Q+VEI RAL+ + +++I+DEPT+ L Sbjct: 123 TNMKQLAEQIRETALRYGLPLEPNRHVHTLSVGERQRVEIVRALLAKPQLLILDEPTSVL 182 Query: 175 SERETEQLFNVVRRLRDEGLAIIYISHRMAEVYALADRVTVLRDGSFVGELVRDEIDSER 234 + + + LF +R+L EG +I+YISH++ E+ L TV+R G G + + Sbjct: 183 TPQAVQTLFITLRQLAAEGTSILYISHKLDEIRELCHSATVMRMGRVTGVCDPRQESAAS 242 Query: 235 IVQMMVGRSLSEFYQHQ------RIAPADAAQLPTVMQVRALAGGKIRPASFDVRAGEVL 288 + ++M+G + Q R+A + + + LAG S D+RAGE++ Sbjct: 243 LSRLMIGGEPPREARVQTEPGVCRLAVRELSLPRSHAFATELAG-----ISLDLRAGEIV 297 Query: 289 GFAGLVGAGRTELARLLFGADPRSGGD-ILLEGRPVHIDQPRAAMRAGIAYVPEDRKGQG 347 G AG+ G G+ EL L G D R+ D I L+ +PV R RAG+A+VPE+R G+G Sbjct: 298 GIAGVSGNGQQELLAALSGEDVRAARDAITLDNKPVGKLDARQRRRAGLAFVPEERLGRG 357 Query: 348 LFLQMAVAANATMNVASR-HTRLGLVRSRSLGGVARAAIQRLNVKVAHPETPVGKLSGGN 406 M++AAN ++ S + + G++ ++ G+A+A I RL VK + P LSGGN Sbjct: 358 AVPGMSLAANILLSHQSAPYVQRGMISPKAAAGLAQAVIARLRVKASGPHALAKSLSGGN 417 Query: 407 QQKVLLARWLEIAPKVLILDEPTRGVDIYAKSEIYQLVHRLASQGVAVVVISSELPEVIG 466 QK ++ R +E PKVLI+ +PT GVD+ A ++I+ + L + G A++V+S EL E+ Sbjct: 418 LQKFIVGREIESGPKVLIVAQPTWGVDVGAAAQIHNELLALKATGCALLVVSEELDELFA 477 Query: 467 ICDRVLVMREGMITGELAGAAITQENI 493 ICDR+ V+ +G ++ + T+E + Sbjct: 478 ICDRLHVIAKGRLSPSIPTRDATREQV 504 Score = 84.7 bits (208), Expect = 7e-21 Identities = 69/233 (29%), Positives = 106/233 (45%), Gaps = 9/233 (3%) Query: 279 SFDVRAGEVLGFAGLVGAGRTELARLLFGADPRSGGDILLEGRPVHIDQPRAAMRAGIAY 338 S V GE+ G GAG++ L +++FGA GD+ G I P A GIA Sbjct: 28 SLVVAPGEIHAVLGENGAGKSTLMKIIFGAVKPDAGDMHFNGARAAIHNPHDARNLGIAM 87 Query: 339 VPEDRKGQGLFLQMAVAANATMNVA-SRHTRLGLVRS----RSLGGVARAAIQRLNVKVA 393 V + LF + VA N + + T G + + L R R + + Sbjct: 88 VFQHFS---LFDTLTVAENIALGLPRGSKTAAGSPHAGTNMKQLAEQIRETALRYGLPL- 143 Query: 394 HPETPVGKLSGGNQQKVLLARWLEIAPKVLILDEPTRGVDIYAKSEIYQLVHRLASQGVA 453 P V LS G +Q+V + R L P++LILDEPT + A ++ + +LA++G + Sbjct: 144 EPNRHVHTLSVGERQRVEIVRALLAKPQLLILDEPTSVLTPQAVQTLFITLRQLAAEGTS 203 Query: 454 VVVISSELPEVIGICDRVLVMREGMITGELAGAAITQENIMRLATDTNVPRTA 506 ++ IS +L E+ +C VMR G +TG + ++ RL PR A Sbjct: 204 ILYISHKLDEIRELCHSATVMRMGRVTGVCDPRQESAASLSRLMIGGEPPREA 256 Lambda K H 0.320 0.135 0.378 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 683 Number of extensions: 44 Number of successful extensions: 9 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 2 Number of HSP's successfully gapped: 2 Length of query: 521 Length of database: 529 Length adjustment: 35 Effective length of query: 486 Effective length of database: 494 Effective search space: 240084 Effective search space used: 240084 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory