Align 4-hydroxybenzoyl-CoA reductase, α subunit (EC 1.3.7.9) (characterized)
to candidate 3607631 Dshi_1040 aldehyde oxidase and xanthine dehydrogenase molybdopterin binding (RefSeq)
Query= metacyc::MONOMER-14376 (794 letters) >FitnessBrowser__Dino:3607631 Length = 763 Score = 243 bits (619), Expect = 4e-68 Identities = 228/768 (29%), Positives = 321/768 (41%), Gaps = 55/768 (7%) Query: 34 VTGTARYTADLPAQGALVGKLLRSPYAHAELLEVDISEALKLPGVRGIVTGNDCD----- 88 V G + AD+PA+GAL +++RSPY + +D+ A +PGV +++G D Sbjct: 21 VRGAGCFVADVPAEGALWMEVVRSPYPAGRITALDLDAARAMPGVVCVLSGADQAGLRPF 80 Query: 89 ----TPYGVIPIAQNEFPLARGRIRYVGEPVAAVAAVDEATTDAALALIRLKVRELPAYF 144 P G + P+A R+ +VGEPVA V A A + L+V E P Sbjct: 81 PLRYVPKGCDVVPTPFLPMATDRVTWVGEPVAVVVAETAGQASDAADAVVLEVAEAPVVT 140 Query: 145 DAADARKADVVLLHDNKKGNIEREVHNEFGDAAAGFAAADLICEET---FECAEVHHAMM 201 DA + + ++ NI E GD A AAA T E + V + Sbjct: 141 DARTGAAPEAPRVWPDRDSNIAFTY--ELGDRDAFEAAAARAAHVTRARIEISRVAAMTL 198 Query: 202 EPNASLAAWDNERGHLTLWSVTQVPYYVHESLARCMKLDAAYIRVIKPFVGGGFGHRVET 261 EP +LA E GH+TLW+ TQ P+ V LA + L IRV K GG FG R Sbjct: 199 EPRGALATCSPE-GHMTLWTGTQAPHRVQGELAHVLDLPLDRIRVRKTDTGGSFGMRNGA 257 Query: 262 LNFEIIAGLLARAARGTVRLLQTREEAFLTHRGRPQTYVRMKLGLTRDGRMTACE----A 317 + +A L ARA V TR E FL + V L L DG A + A Sbjct: 258 FPEDALALLAARATGRPVHWQGTRSEGFLADTASREQSVDAALALDADGTFLALQVDGYA 317 Query: 318 EVVQRGGAYGGYGLVTILYAGALLNGLYDLPAVKYDGYRVYTNTPPCGAMRGHGTVNIRF 377 + + G G+ + + L L G+Y P + V+ N RG G + Sbjct: 318 PIGAQMGQMSGHPMTSNLPG---LAGVYRTPVIHAVMRGVHVNAMHMAPYRGAGRPEAIY 374 Query: 378 AFESLLDMMAAELGLDAFAVRRRNLL---KAPTETINGLKVMSYGLPECLDWVEQASGWR 434 E ++++ AAE G D A+R RN++ + P T +G S P L + Sbjct: 375 VIERMVELAAAETGRDPVALRLRNMIGPDQMPWATPHGFTYDSGDFPTALRAALAGADAA 434 Query: 435 ERAARLEANSDGPIRRGIGIACSHFVSGSAKPVHFTGQPHATIALRVDFDAGITILTGAS 494 AAR EA RG+GIAC+ +G G A + G+ I TGA Sbjct: 435 GFAARREAARARGRLRGLGIACAIEPAGGGP----KGAQLPEYAQLIAGPEGLEIRTGAG 490 Query: 495 DIGQGSSTIITQVVAEILGVEYRRLRLIATDSALTPKDNGSYSSRVTFMVGNAAADAARN 554 D GQG +T Q+ +LG + + D+ + G++ SR VG A + Sbjct: 491 DAGQGHATAFAQIAERLLGWR-GPVTVRGGDTGEIARGTGTFGSRTMGSVGAAMQAGSAQ 549 Query: 555 LKAVLVAAAAKRLQVAEADVDWLGEAAAVVGDASRQIPFHDIVEEALVDVGMLTVKGTFT 614 + AA L+VA D+ + A V G R IP ++ TFT Sbjct: 550 ILEAARPEAADLLEVAARDLVFAQGAFRVAG-TDRAIPLAEVTAR---------TGRTFT 599 Query: 615 CPPEFQGGKQRGGAVGSTMG-FSYAAQAVEVSVDTELGKVTVEKVWSAIDCGFAINPMSV 673 V + G F A EV VD + G V + A D G INP+ V Sbjct: 600 AE----------AFVATEAGTFPNGAHVAEVEVDPDTGAVQLAAYTVADDVGTVINPLLV 649 Query: 674 EGQVQGAIWMGMGQAISEETVYE-NGRHKAVSLLDYRVPTIIESPDIAVHIVESLDPNGP 732 EGQV G + G+GQA+ E V++ + SL+DY VP + I V + P Sbjct: 650 EGQVHGGVAQGLGQALMERIVHDADAALLTGSLMDYAVPRATDLCRIEVLHTPTPTTANP 709 Query: 733 FGAKEASEGPLAGVMSAIAAAIEDATG---TRIRATPFTPDRVFDALN 777 G K A E G ++A+ A+ DA G R P +P RV+ ALN Sbjct: 710 LGVKGAGESGTVGALAAVMNAVCDAIGPEAARRLQMPASPHRVWAALN 757 Lambda K H 0.319 0.135 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 1516 Number of extensions: 94 Number of successful extensions: 8 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 794 Length of database: 763 Length adjustment: 41 Effective length of query: 753 Effective length of database: 722 Effective search space: 543666 Effective search space used: 543666 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 55 (25.8 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory