Align arginine decarboxylase (EC 4.1.1.19) (characterized)
to candidate HSERO_RS17280 HSERO_RS17280 lysine decarboxylase
Query= BRENDA::E8X9U7 (756 letters) >FitnessBrowser__HerbieS:HSERO_RS17280 Length = 750 Score = 505 bits (1301), Expect = e-147 Identities = 273/766 (35%), Positives = 428/766 (55%), Gaps = 37/766 (4%) Query: 4 VLIVESEFLHQDTWVGNAVERLADALSQQNVTVIKSTSFDDGYAILSANEAIDCLMFSYQ 63 ++I++ +F ++T G + LADA+ + + V+ TS+ D + S Sbjct: 7 IVIIDEDFRSENT-SGLGIRALADAIEAEGMEVLGVTSYGDLAQFAQQQSRASAFILSID 65 Query: 64 MEQ----PDEHL-----SVRQLIGKLHERQQNVPVFLLGDREKATASLDRDLLELVDEFA 114 E+ DE ++R + ++ + ++P++L G+ + + + D+L + F Sbjct: 66 DEEMGAGSDEETDHALKALRAFVSEIRHKNADIPIYLYGET-RTSRHIPNDVLRELHGFI 124 Query: 115 WILEDTADFIAGRAVAAMTRYRQQLLPPLFNALMKYSDIHEYSWAAPGHQGGVGFTKTPA 174 + EDT +F+A + Y L PP F AL+ Y+ YSW PGH GGV F K+P Sbjct: 125 HMFEDTPEFVARHIIREAKSYLDGLAPPFFRALVDYAQDGSYSWHCPGHSGGVAFLKSPV 184 Query: 175 GRFYHDYYGENLFRSDMGIERTTLGSLLDHTGAFGESEKNAARVFGADRSWSVVVGTSGS 234 G+ +H ++GE + R+D+ LG LLDHTG SE+NAAR+F AD + V GTS S Sbjct: 185 GQMFHQFFGERMLRADVCNAVEELGQLLDHTGPVANSERNAARIFNADHCYFVTNGTSTS 244 Query: 235 NRTIMQACMTDNDVVVLDRNCHKSIEQGLILTGAKPVYMVPSRNRYGIIGPIYPQEMQPE 294 N+ + + + D+VV+DRNCHKSI +I+TGA PV+++P+RN GIIGPI +E E Sbjct: 245 NKMVWHSTVAPGDIVVVDRNCHKSILHSIIMTGAIPVFLMPTRNHLGIIGPIPLEEFTLE 304 Query: 295 TLQKKISASPLTKTKAGQKPSYSVVTNCTYDGVCYNAKEAQDLLAKTSDRIHFDEAWYGY 354 ++QKKI A+P + +KP +T TYDGV YN + +D+L + +HFDEAW + Sbjct: 305 SIQKKIEANPFAREAKNKKPRILTITQSTYDGVVYNVETLKDMLDGEIETLHFDEAWLPH 364 Query: 355 ARFNPIYCDHYAMRGEPGDHNGPTVFATHSTHKLLNALSQASYIHVREGRGA-VNFSRFN 413 A F+ Y D +A+ + +F+T STHKLL LSQAS I VRE ++ FN Sbjct: 365 ATFHDFYKDMHAIGKDRPRAKKSLIFSTQSTHKLLAGLSQASQILVRESETVKLDEDAFN 424 Query: 414 QAYMMHATTSPLYAICASNDVAVSMMDGNSGLSLTQEVIDEAVDFRQAMARLYKEFTDEG 473 +A++MH +TSP Y+I AS DVA +MM+ G +L +E I EA+DFR+AM ++ +EF DE Sbjct: 425 EAFLMHTSTSPQYSIIASCDVAAAMMEAPGGTALVEESILEALDFRRAMKKIDQEFGDE- 483 Query: 474 DWFFKPWNKDVVTDPQTGKTYDFADAPAKLLATDQNCWVMRPGETWHGFKDLPDNWSMLD 533 W+F+ W + G+ D WV++ + WHGF +L ++MLD Sbjct: 484 -WWFQVWGPNSFAADGIGERED---------------WVIKAEDDWHGFGNLAPGFNMLD 527 Query: 534 PIKVSILAPGMGDDGELEASGVPAALVTAWLGRHGIVPTRTTDFQIMFLFSMGVTRGKWG 593 PIK +I+ PG+ +G+ +G+PA++VT +L HG++ + + +F++G+T+G+W Sbjct: 528 PIKATIVNPGLALNGQFGETGIPASIVTKYLAEHGVIVEKCGLYSFFIMFTIGITKGRWN 587 Query: 594 TLINTLCSFKHHYDANTPLAQVMPELVQDYPDTYANMGIHDLGDKMFAWLRENNPGARLN 653 TL+ L FK YD N P+ +++PE Q P Y +G+ DL ++ R + Sbjct: 588 TLVTALQQFKDDYDKNQPIWRILPEFAQRNP-RYERLGLRDLCQQIHETYRAYDVARLTT 646 Query: 654 AAYSTLPVAEITPRDAYNAIVNNNIEMVAIENLPGRIAANSVIPYPPGIPMLLSGENFGD 713 Y + + P DA++ + + IE V ++ L GR+ + + PYPPGIP+L+ GE F Sbjct: 647 EMYLSDMQPAMKPSDAFSKMAHREIERVPLDELEGRVTSILLTPYPPGIPLLIPGEIF-- 704 Query: 714 ENSPQVGYLRSLQSWDHHFPGFEHETEG--TEIIDG--VYHVMCVK 755 N V YL+ + ++ FPGFE + G ++G Y V CVK Sbjct: 705 -NKTIVDYLKFARDFNEKFPGFETDVHGLVKREVNGRRDYFVDCVK 749 Lambda K H 0.319 0.135 0.415 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 1434 Number of extensions: 65 Number of successful extensions: 7 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 756 Length of database: 750 Length adjustment: 40 Effective length of query: 716 Effective length of database: 710 Effective search space: 508360 Effective search space used: 508360 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 55 (25.8 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory