Align Arabinose import ATP-binding protein AraG; EC 7.5.2.12 (characterized, see rationale)
to candidate HSERO_RS05250 HSERO_RS05250 D-ribose transporter ATP binding protein
Query= uniprot:B2SYR5 (512 letters) >FitnessBrowser__HerbieS:HSERO_RS05250 Length = 520 Score = 404 bits (1037), Expect = e-117 Identities = 218/498 (43%), Positives = 324/498 (65%), Gaps = 16/498 (3%) Query: 9 NIGKVFPGVRALDGVSFDVNVGQVHGLMGENGAGKSTLLKILGGEYQPDSGRVMIDGNEV 68 N+ K FPGV ALD F++ G+VH LMGENGAGKSTL+KIL G YQ DSG +++DG V Sbjct: 27 NVCKRFPGVLALDNCQFELAAGEVHALMGENGAGKSTLMKILSGVYQRDSGDILLDGKPV 86 Query: 69 RFTSAASSIAAGIAVIHQELQYVPDLTVAENLLLGQLP-NSLGW------VNKREAKRFV 121 T + A GI +IHQEL + L+ A+N+ +G+ P ++G +N++ A F Sbjct: 87 EITEPRQAQALGIGIIHQELNLMNHLSAAQNIFIGREPRKAMGLFIDEDELNRQAAAIFA 146 Query: 122 RERLEAMGVALDPNAKLRKLSIAQRQMVEICKALLRNARVIALDEPTSSLSHRETEVLFK 181 R RL+ +DP+ + +L++A++QMVEI KAL ++RV+ +DEPT++L++ E LF+ Sbjct: 147 RMRLD-----MDPSTPVGELTVARQQMVEIAKALSFDSRVLIMDEPTAALNNAEIAELFR 201 Query: 182 LVRDLRADNRAMIYISHRMDEIYELCDACTIFRDGRKIASHPTLEGVTRDTIVSEMVGRE 241 ++RDL+A ++YISH+MDE+ ++ D ++ RDG+ IA+ P ++ + DTI+S MVGR Sbjct: 202 IIRDLQAQGVGIVYISHKMDELRQIADRVSVMRDGKYIATVP-MQETSMDTIISMMVGRA 260 Query: 242 ISDIYNYSA-RPLGEVRFAAKGIEGHALAQPASFEVRRGEIVGFFGLVGAGRSELMHLVY 300 + +V +G+ + SF +R+GEI+GF GL+GAGR+E+ ++ Sbjct: 261 LDGEQRIPPDTSRNDVVLEVRGLNRGRAIRDVSFTLRKGEILGFAGLMGAGRTEVARAIF 320 Query: 301 GADHKKGGELLLDGKPIKVRSAGEAIRHGIVLCPEDRKEEGIVAMATVSENINISCRRHY 360 GAD + GE+++ G ++S +A+ HGI EDRK G+ V NI +S + Sbjct: 321 GADPLEAGEIIIHGGKAVIKSPADAVAHGIGYLSEDRKHFGLAVGMDVQANIALSSMGRF 380 Query: 361 LRVGMFLDRKKEAETADRFIKLLKIKTPSRRQKIRFLSGGNQQKAILSRWLAEPDLKVVI 420 RVG F+D++ E A +++ L IKTPS Q+ R LSGGNQQK ++++WL D ++ Sbjct: 381 TRVG-FMDQRAIREAAQMYVRQLAIKTPSVEQQARLLSGGNQQKIVIAKWLLR-DCDILF 438 Query: 421 LDEPTRGIDVGAKHEIYNVIYQLAERGCAIVMISSELPEVLGVSDRIVVMRQGRISGELT 480 DEPTRGIDVGAK EIY ++ LAE+G AIVMISSELPEVL +S R++VM +GRI+GEL Sbjct: 439 FDEPTRGIDVGAKSEIYKLLDALAEQGKAIVMISSELPEVLRMSHRVLVMCEGRITGELA 498 Query: 481 RKDATEQSVLSLALPQSS 498 R DAT++ ++ LA + S Sbjct: 499 RADATQEKIMQLATQRES 516 Score = 93.6 bits (231), Expect = 2e-23 Identities = 70/258 (27%), Positives = 130/258 (50%), Gaps = 11/258 (4%) Query: 249 SARPLGEVRFAAKGIEGHALAQPASFEVRRGEIVGFFGLVGAGRSELMHLVYGADHKKGG 308 S+ P+ +R K G FE+ GE+ G GAG+S LM ++ G + G Sbjct: 18 SSVPVIALRNVCKRFPGVLALDNCQFELAAGEVHALMGENGAGKSTLMKILSGVYQRDSG 77 Query: 309 ELLLDGKPIKVRSAGEAIRHGIVLCPEDRKEEGIVAMATVSENINISCRRHYLRVGMFLD 368 ++LLDGKP+++ +A GI + +E ++ + ++NI I R +G+F+D Sbjct: 78 DILLDGKPVEITEPRQAQALGIGII---HQELNLMNHLSAAQNIFIG-REPRKAMGLFID 133 Query: 369 RKK-EAETADRFIKLLKIKTPSRRQKIRFLSGGNQQKAILSRWLAEPDLKVVILDEPTRG 427 + + A F ++ PS + L+ QQ +++ L+ D +V+I+DEPT Sbjct: 134 EDELNRQAAAIFARMRLDMDPS--TPVGELTVARQQMVEIAKALSF-DSRVLIMDEPTAA 190 Query: 428 IDVGAKHEIYNVIYQLAERGCAIVMISSELPEVLGVSDRIVVMRQGRISGELTRKDATEQ 487 ++ E++ +I L +G IV IS ++ E+ ++DR+ VMR G+ + ++ + Sbjct: 191 LNNAEIAELFRIIRDLQAQGVGIVYISHKMDELRQIADRVSVMRDGKYIATVPMQETSMD 250 Query: 488 SVLSLALPQSSTALPGTQ 505 +++S+ + AL G Q Sbjct: 251 TIISMMV---GRALDGEQ 265 Lambda K H 0.320 0.136 0.385 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 654 Number of extensions: 27 Number of successful extensions: 10 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 2 Number of HSP's successfully gapped: 2 Length of query: 512 Length of database: 520 Length adjustment: 35 Effective length of query: 477 Effective length of database: 485 Effective search space: 231345 Effective search space used: 231345 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory