Align gluconate:H+ symporter (gntT) (characterized)
to candidate HSERO_RS08740 HSERO_RS08740 permease
Query= reanno::Cup4G11:RR42_RS28835 (453 letters) >FitnessBrowser__HerbieS:HSERO_RS08740 Length = 450 Score = 698 bits (1802), Expect = 0.0 Identities = 358/453 (79%), Positives = 397/453 (87%), Gaps = 3/453 (0%) Query: 1 MGAVTGTTLLLYALIAVIALVVLIAKFKLNPFITLVVVSVLLGFAVGMPMGDIVKSFEAG 60 M AV G+ LL+YAL+AVIAL+VLIAKFK+NPFI L+VVS++LG AVGMPMG+IVK+FE G Sbjct: 1 MEAVQGSALLVYALVAVIALIVLIAKFKMNPFIVLIVVSLVLGLAVGMPMGNIVKAFETG 60 Query: 61 VGGTLGHIALVVGLGTMLGKMMAESGGAERIARTLIDAFGEKNVHWAMVTIAFIVGLPVF 120 VG LGHIALVVGLGTMLGKMMAESGGAERIA T+I AFGEKNVHWAM+T+AFIVGLPVF Sbjct: 61 VGNALGHIALVVGLGTMLGKMMAESGGAERIANTMIKAFGEKNVHWAMMTVAFIVGLPVF 120 Query: 121 FEVGFVLLVPIAFNVAKRTGTSMVLVGIPMVAGLSVVHGLIPPHPAALLAVTAYKADIGK 180 FEVGFVLLVPIAFNVAKRTGT+MVLVGIPMVAGLSVVHGLIPPHPAALLAVTAY ADIG+ Sbjct: 121 FEVGFVLLVPIAFNVAKRTGTNMVLVGIPMVAGLSVVHGLIPPHPAALLAVTAYSADIGR 180 Query: 181 TILYALIVGIPTAAIAGPLFAKLMTRYVTLPDVNPLAAQFTEEDEGVKASHELPGFGITL 240 TILYALIVGIPTA IAGP+F KL+++ V NPL +QF +E K ELPGFGITL Sbjct: 181 TILYALIVGIPTAIIAGPIFGKLISKVVIPNPDNPLISQFVDEG---KKDRELPGFGITL 237 Query: 241 FTILLPVILMLIGSWADLITTPKTFANDFLKLIGNSVIALLIAALVSFYTFGKRRGFTRE 300 FTILLPV LMLIGSWADL PKTFANDFL+LIGNSVIALLIA LVSF+TFG+ RGF + Sbjct: 238 FTILLPVALMLIGSWADLFFAPKTFANDFLRLIGNSVIALLIATLVSFWTFGRARGFGAD 297 Query: 301 NILRFTNECVAPTAIITLVVGAGGGFGRVLRDSGISNAIVDVATGAHVSVLLLGWLVAVL 360 IL+FTNEC+AP A ITLVVGAG GFGR+L D G+S AIV +AT AH+S L+LGW VA L Sbjct: 298 QILKFTNECLAPIASITLVVGAGAGFGRILMDGGVSKAIVGIATDAHLSPLILGWFVAAL 357 Query: 361 IRIATGSATVAMTTAAGIVAPIAASVPGTRPELLVLTTGAGSLILSHVNDGGFWLVKEYF 420 IR+ATGSATVAMTTA GIVAPI ++V G RPEL+VL TGAGSLILSHVNDGGFWLVKEYF Sbjct: 358 IRVATGSATVAMTTACGIVAPIVSTVGGVRPELMVLATGAGSLILSHVNDGGFWLVKEYF 417 Query: 421 NMTVAQTFKTWSVCETLISVIALLLTLALATVV 453 NMTV QTFKTW+V ETL+SV+ALL TLALATVV Sbjct: 418 NMTVPQTFKTWTVMETLVSVLALLFTLALATVV 450 Lambda K H 0.326 0.141 0.410 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 839 Number of extensions: 46 Number of successful extensions: 4 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 453 Length of database: 450 Length adjustment: 33 Effective length of query: 420 Effective length of database: 417 Effective search space: 175140 Effective search space used: 175140 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 51 (24.3 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory